Search results for: tissue and vein properties
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 3107

Search results for: tissue and vein properties

2837 Thermal and Mechanical Properties of Basalt Fibre Reinforced Concrete

Authors: Tumadhir M., Borhan

Abstract:

In this study, the thermal and mechanical properties of basalt fibre reinforced concrete were investigated. The volume fractions of basalt fibre of (0.1, 0.2, 0.3, and 0.5% by total mix volume) were used. Properties such as heat transfer, compressive and splitting tensile strengths were examined. Results indicated that the strength increases with increase the fibre content till 0.3% then there is a slight reduction when 0.5% fibre used. Lower amount of heat conducted through the thickness of concrete specimens than the conventional concrete was also recorded.

Keywords: Chopped basalt fibre, Compressive strength, Splitting tensile strength, Heat transfer.

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2836 Mechanical Contribution of Silica Fume and Hydrated Lime Addition in Mortars Assessed by Ultrasonic Pulse Velocity Tests

Authors: Nacim Khelil, Amar Kahil, Said Boukais

Abstract:

The aim of the present study is to investigate the changes in the mechanical properties of mortars including additions of Condensed Silica Fume (CSF), Hydrated Lime (CH) or both at various amounts (5% to 15% of cement replacement) and high water ratios (w/b) (0.4 to 0.7). The physical and mechanical changes in the mixes were evaluated using non-destructive tests (Ultrasonic Pulse Velocity (UPV)) and destructive tests (crushing tests) on 28 day-long specimens consecutively, in order to assess CSF and CH replacement rate influence on the mechanical and physical properties of the mortars, as well as CSF-CH pre-mixing on the improvement of these properties. A significant improvement of the mechanical properties of the CSF, CSF-CH mortars, has been noted. CSF-CH mixes showed the best improvements exceeding 50% improvement, showing the sizable pozzolanic reaction contribution to the specimen strength development. UPV tests have shown increased velocities for CSF and CSH mixes, however no proportional evolution with compressive strengths could be noted. The results of the study show that CSF-CH addition could represent a suitable solution to significantly increase the mechanical properties of mortars.

Keywords: Compressive strength, condensed silica fume, hydrated lime, pozzolanic reaction, UPV testing.

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2835 Effect of Dietary Supplementation of Allium Hookeri Root and Processed Sulfur on the Growth Performance of Guinea Pigs

Authors: Nayeon, Lee, Won-Young, Cho, Hyun Joo, Jang, Chi-Ho, Lee

Abstract:

This study investigated the effects of the dietary supplementation of the Allium hookeri root, and processed sulfur, on the growth performance of guinea pigs. The guinea pigs were fed a control diet (CON), as well as the control diet including 1% freeze-dried Allium hookeri root (AH), or 0.1% processed sulfur (S), or including both the freeze-dried Allium hookeri root and the processed sulfur (AHS). The weight of perirenal adipose tissue (PAT) and the epididymal adipose tissue (EAT) in the AH were significantly lower than CON (p < 0.05). The serum cholesterols levels of the AH and the AHS were significantly lower than the S (p < 0.05). While the total saturated fatty acid content in the serum of the AH and AHS groups showed a tendency to decrease, the total monounsaturated fatty acid increased. The results of this study suggested that dietary consumption of Allium hookeri root may help to decrease fat accumulation, lower serum cholesterol levels, and control serum free fatty acid contents in the guinea pigs.

Keywords: Allium hookeri, processed sulfur, dietary supplementation, growth performance, guinea pig.

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2834 Combined Effect of Cold Rolling and Heat Treatment on the Mechanical Properties of Al-Ti Alloy

Authors: Adeosun S. Oluropo, Sekunowo O. Israel, Talabi S. Isaac

Abstract:

This study investigated the combined effect of cold rolling and heat treatment on the mechanical properties of Al-Ti alloy. Samples of the alloy are cast in metal mould to obtain 0.94-2.19wt% mixes of titanium. These samples are grouped into untreated (as-cast) and those that are cold rolled to fifty percent reduction, homogenized at 5000C and soaked for one hour. The cold rolled and heat treated samples are normalized (RTn) and quench-tempered (RTq-t) at 1000C. All these samples are subjected to tensile, micro-hardness and microstructural evaluation. Results show remarkable improvement in the mechanical properties of the cold rolled and heat treated samples compared to the as-cast. In particular, the RTq-t samples containing titanium in the range of 1.7-2.2% demonstrates improve tensile strength by 24.7%, yield strength, 28%, elastic modulus, 38.3% and micro-hardness, 20.5%. The Al3Ti phase being the most stable precipitate in the α-Al matrix appears to have been responsible for the significant improvement in the alloy’s mechanical properties. It is concluded that quench and temper heat treatment is an effective method of improving the strength-strain ratio of cold rolled Al-.0.9-2.2%Ti alloy.

Keywords: Aluminum-titanium alloy, heat treatment, mechanical properties, precipitate.

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2833 Influence of Hygro-Chemo-Mechanical Degradation on Performance of Concrete Gravity Dam

Authors: Kalyan Kumar Mandal, Damodar Maity

Abstract:

The degradation of concrete due to various hygrochemo- mechanical actions is inevitable for the structures particularly built to store water. Therefore, it is essential to determine the material properties of dam-like structures due to ageing to predict the behavior of such structures after a certain age. The degraded material properties are calculated by introducing isotropic degradation index. The predicted material properties are used to study the behavior of aged dam at different ages. The dam is modeled by finite elements and displacement and is considered as an unknown variable. The parametric study reveals that the displacement is quite larger for comparatively lower design life of the structure because the degradation of elastic properties depends on the design life of the dam. The stresses in dam cam be unexpectedly large at any age with in the design life. The outcomes of the present study indicate the importance of the consideration ageing effect of concrete exposed to water for the safe design of dam throughout its life time.

Keywords: Hygro-chemo-mechanical, isotropic degradation, finite element method, Koyna earthquake.

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2832 Development of Prediction Tool for Sound Absorption and Sound Insulation for Sound Proof Properties

Authors: Yoshio Kurosawa, Takao Yamaguchi

Abstract:

High frequency automotive interior noise above 500 Hz considerably affects automotive passenger comfort. To reduce this noise, sound insulation material is often laminated on body panels or interior trim panels. For a more effective noise reduction, the sound reduction properties of this laminated structure need to be estimated. We have developed a new calculate tool that can roughly calculate the sound absorption and insulation properties of laminate structure and handy for designers. In this report, the outline of this tool and an analysis example applied to floor mat are introduced.

Keywords: Automobile, acoustics, porous material, Transfer Matrix Method.

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2831 Rheological Properties of Dough and Sensory Quality of Crackers with Dietary Fibers

Authors: Ljubica Dokić, Ivana Nikolić, Dragana Šoronja–Simović, Zita Šereš, Biljana Pajin, Nils Juul, Nikola Maravić

Abstract:

The possibility of application the dietary fibers in production of crackers was observed in this work, as well as their influence on rheological and textural properties on the dough for crackers and influence on sensory properties of obtained crackers. Three different dietary fibers, oat, potato and pea fibers, replaced 10% of wheat flour. Long fermentation process and baking test method were used for crackers production. The changes of dough for crackers were observed by rheological methods of determination the viscoelastic dough properties and by textural measurements. Sensory quality of obtained crackers was described using quantity descriptive method (QDA) by trained members of descriptive panel. Additional analysis of crackers surface was performed by videometer. Based on rheological determination, viscoelastic properties of dough for crackers were reduced by application of dietary fibers. Manipulation of dough with 10% of potato fiber was disabled, thus the recipe modification included increase in water content at 35%. Dough compliance to constant stress for samples with dietary fibers decreased, due to more rigid and stiffer dough consistency compared to control sample. Also, hardness of dough for these samples increased and dough extensibility decreased. Sensory properties of final products, crackers, were reduced compared to control sample. Application of dietary fibers affected mostly hardness, structure and crispness of the crackers. Observed crackers were low marked for flavor and taste, due to influence of fibers specific aroma. The sample with 10% of potato fibers and increased water content was the most adaptable to applied stresses and to production process. Also this sample was close to control sample without dietary fibers by evaluation of sensory properties and by results of videometer method.

Keywords: Crackers, dietary fibers, rheology, sensory properties.

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2830 Effect of Laser Welding Properties on Ti/Al Dissimilar Thin Sheets – A Review

Authors: K. Kalaiselvan, A. Elango, N.M. Nagarajan

Abstract:

Laser beam welding is an important joining technique for Titanium/Aluminum thin sheet alloys with their increasing applications in aerospace, aircraft, automotive, electronics and other industries. In this paper the research and progress in laser welding of Ti/Al thin sheets are critically reviewed from different perspectives. Some important aspects such as microstructure, metallurgical defects and mechanical properties in weldments are discussed. Also the recent progress in laser welding of Ti/Al dissimilar thin sheets to provide a basis for further research work is reported.

Keywords: Laser welding, Titanium/Aluminium sheets, microstructure, metallurgical defects and mechanical properties.

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2829 Influence of Rolling Temperature on Microstructure and Mechanical Properties of Cryorolled Al-Mg-Si Alloy

Authors: B. Gopi, N. Naga Krishna, K. Venkateswarlu, K. Sivaprasad

Abstract:

An effect of rolling temperature on the mechanical properties and microstructural evolution of an Al-Mg-Si alloy was studied. The material was rolled up to a true strain of ~0.7 at three different temperatures viz; room temperature, liquid propanol and liquid nitrogen. The liquid nitrogen rolled sample exhibited superior properties with a yield and tensile strength of 332 MPa and 364 MPa, respectively, with a reasonably good ductility of ~9%. The liquid nitrogen rolled sample showed around 54 MPa increase in tensile strength without much reduction in the ductility as compared to the as received T6 condition alloy. The microstructural details revealed equiaxed grains in the annealed and solutionized sample and elongated grains in the rolled samples. In addition, the cryorolled samples exhibited fine grain structure compared to the room temperature rolled samples.

Keywords: Al-Mg-Si alloy, cryorolling, tensile properties, ultra-fine grain structure.

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2828 Effect of Friction Stir Welding on Microstructural and Mechanical Properties of Copper Alloy

Authors: Dhananjayulu Avula, Ratnesh Kumar Raj Singh, D.K.Dwivedi, N.K.Mehta

Abstract:

This study demonstrates the feasibility of joining the commercial pure copper plates by friction stir welding (FSW). Microstructure, microhardness and tensile properties in terms of the joint efficiency were found 94.03 % compare to as receive base material (BM). The average hardness at the top was higher than bottom. Hardness of weld zone was higher than the base material. Different microstructure zones were revealed by optical microscopy and scanning electron microscopy. The stirred zone (SZ) exhibited primary two phases namely, recrystallized grains and fine precipitates in matrix of copper.

Keywords: Welding; FSW, Commercial Copper, Mechanical properties

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2827 Weakly Generalized Closed Map

Authors: R. Parimelazhagan, N. Nagaveni

Abstract:

In this paper we introduce a new class of mg-continuous mapping and studied some of its basic properties.We obtain some characterizations of such functions. Moreover we define sub minimal structure and further study certain properties of mg-closed sets.

Keywords: M-structure, mg-continuous mapping, minimal structure, mg T2 space, sub minimal structure, T12 space, mg-compact set.

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2826 The Role of Halloysite’s Surface Area and Aspect Ratio on Tensile Properties of Ethylene Propylene Diene Monomer Nanocomposites

Authors: Pooria Pasbakhsh, Rangika T. De Silva, Vahdat Vahedi, Hanafi Ismail

Abstract:

The influence of three different types of halloysite nanotubes (HNTs) with different dimensions, namely as camel lake (CLA), Jarrahdale (JA) and Matauri Bay (MB), on their reinforcing ability of ethylene propylene dine monomer (EPDM) were investigated by varying the HNTs loading (from 0-15 phr). Mechanical properties of the nanocomposites improved with addition of all three HNTs, but CLA based nanocomposites exhibited a significant enhancement compared to the other HNTs. For instance, tensile properties of EPDM nanocomposites increased by 120%, 256% and 340% for MB, JA and CLA, respectively, with addition of 15 phr of HNTs. This could be due to the higher aspect ratio and higher surface area of CLA compared to others. Scanning electron microscopy (SEM) of nanocomposites at 15 phr of HNT loadings showed low amounts of pulled-out nanotubes which confirmed the presence of more embedded nanotubes inside the EPDM matrix, as well as aggregates within the fracture surface of EPDM/HNT nanocomposites

Keywords: Aspect ratio, Halloysite nanotubes (HNTs), Mechanical properties, Rubber/clay nanocomposites.

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2825 Structural and Electrical Properties of BNT-BT0.08 Ceramics Processed by Spark Plasma Sintering

Authors: Ciceron Berbecaru, Marin Cernea, Gheorghe Virgil Aldica, Roxana Trusca

Abstract:

(Bi0.5Na0.5)TiO3 doped with 8 mol % BaTiO3 powder (BNT-BT0.08), prepared by sol-gel method was compacted and sintered by Spark Plasma Sintering (SPS) process. The influence of SPS temperature on the densification of BNT-BT0.08 ceramic was investigated. Starting from sol-gel nanopowder of BNT-BT containing 8 mol % BaTiO3 with an average particles size of about 30 nm, were obtained ceramics with density around 98 % of the theoretical density value when the SPS temperature used was about 850 °C. The average grain size of the resulting ceramics was 80 nm. The BNT-BT0.08 ceramic sample obtained by SPS method has shown good electric properties at various frequencies.

Keywords: (Bi0.5Na0.5)TiO3 doped with BaTiO3, Spark PlasmaSintering (SPS), dielectric properties

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2824 Protein Quality of Game Meat Hunted in Latvia

Authors: Vita Strazdina, Aleksandrs Jemeljanovs, Vita Sterna

Abstract:

Not all proteins have the same nutritional value, since protein quality strongly depends on its amino acid composition and digestibility. The meat of game animals could be a high protein source because of its well-balanced essential amino acids composition. Investigations about biochemical composition of game meat such as wild boar (Sus scrofa scrofa), roe deer (Capreolus capreolus) and beaver (Castor fiber) are not very much. Therefore, the aim of the investigation was evaluate protein composition of game meat hunted in Latvia. The biochemical analysis, evaluation of connective tissue and essential amino acids in meat samples were done, the amino acids score were calculate. Results of analysis showed that protein content 20.88-22.05% of all types of meat samples is not different statistically. The content of connective tissue from 1.3% in roe deer till 1.5% in beaver meat allowed classified game animal as high quality meat. The sum of essential amino acids in game meat samples were determined 7.05–8.26g100g-1. Roe deer meat has highest protein content and lowest content of connective tissues among game meat hunted in Latvia. Concluded that amino acid score for limiting amino acids phenylalanine and tyrosine is high and shows high biological value of game meat.

Keywords: Dietic product, game meat, amino acids, scores.

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2823 Topological Properties of an Exponential Random Geometric Graph Process

Authors: Yilun Shang

Abstract:

In this paper we consider a one-dimensional random geometric graph process with the inter-nodal gaps evolving according to an exponential AR(1) process. The transition probability matrix and stationary distribution are derived for the Markov chains concerning connectivity and the number of components. We analyze the algorithm for hitting time regarding disconnectivity. In addition to dynamical properties, we also study topological properties for static snapshots. We obtain the degree distributions as well as asymptotic precise bounds and strong law of large numbers for connectivity threshold distance and the largest nearest neighbor distance amongst others. Both exact results and limit theorems are provided in this paper.

Keywords: random geometric graph, autoregressive process, degree, connectivity, Markovian, wireless network.

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2822 Pectoral Muscles Suppression in Digital Mammograms Using Hybridization of Soft Computing Methods

Authors: I. Laurence Aroquiaraj, K. Thangavel

Abstract:

Breast region segmentation is an essential prerequisite in computerized analysis of mammograms. It aims at separating the breast tissue from the background of the mammogram and it includes two independent segmentations. The first segments the background region which usually contains annotations, labels and frames from the whole breast region, while the second removes the pectoral muscle portion (present in Medio Lateral Oblique (MLO) views) from the rest of the breast tissue. In this paper we propose hybridization of Connected Component Labeling (CCL), Fuzzy, and Straight line methods. Our proposed methods worked good for separating pectoral region. After removal pectoral muscle from the mammogram, further processing is confined to the breast region alone. To demonstrate the validity of our segmentation algorithm, it is extensively tested using over 322 mammographic images from the Mammographic Image Analysis Society (MIAS) database. The segmentation results were evaluated using a Mean Absolute Error (MAE), Hausdroff Distance (HD), Probabilistic Rand Index (PRI), Local Consistency Error (LCE) and Tanimoto Coefficient (TC). The hybridization of fuzzy with straight line method is given more than 96% of the curve segmentations to be adequate or better. In addition a comparison with similar approaches from the state of the art has been given, obtaining slightly improved results. Experimental results demonstrate the effectiveness of the proposed approach.

Keywords: X-ray Mammography, CCL, Fuzzy, Straight line.

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2821 Effect of Local Dual Frequency Sonication on Drug Distribution from Nanomicelles

Authors: Hadi Hasanzadeh, Manijhe Mokhtari-Dizaji, S.Zahra Bathaie, Zuhair M. Hassan, Hamid R. Miri, Mahbobe Alamolhoda, Vahid Nilchiani, Hamid Goudarzi

Abstract:

The nanosized polymeric micelles release the drug due to acoustic cavitation, which is enhanced in dual frequency ultrasonic fields. In this study, adult female Balb/C mice were transplanted with spontaneous breast adenocarcinoma tumors and were injected with a dose of 1.3 mg/kg doxorubicin in one of three forms: free doxorubicin, micellar doxorubicin without sonication and micellar doxorubicin with sonication. To increase cavitation yield, the tumor region was sonicated with low level dual frequency of 3 MHz and 28 kHz. The animals were sacrificed 24 h after injection, and their tumor, heart, spleen, liver, kidneys and plasma were separated and homogenized. The drug content in their tumor, heart, spleen, liver, kidneys and plasma was determined using tissue fluorimetry. The results show that in the group that received micellar doxorubicin with sonication, the drug concentration in the tumor tissue was nine and three times higher than in the free doxorubicin group and the micellar doxorubicin without sonication group, respectively. In the micellar doxorubicin with sonication group, the drug concentration in other tissues was lower than other groups (p<0.05). We conclude that dual frequency sonication improves drug release from micelles and increases the drug uptake by tumors due to sonoporation.

Keywords: Nanomicelles, Dual frequency ultrasound, Drug delivery

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2820 Determination of Some Physical and Mechanical Properties of Pofaki Variety of Pea

Authors: M. Azadbakht, E. Ghajarjazi, E. Amiri, F. Abdigaol

Abstract:

In this research the effect of moisture at three levels (47, 57, and 67 w.b.%) on the physical properties of the Pofaki pea variety including, dimensions, geometric mean diameter, volume, sphericity index and the surface area was determined. The influence of different moisture levels (47, 57 and 67 w.b.%), in two loading orientation (longitudinal and transverse) and three loading speed (4,6 and 8 mm min-1) on the mechanical properties of pea such as maximum deformation, rupture force, rupture energy, toughness and the power to break the pea was investigated. It was observed in the physical properties that moisture changes were affective at 1% on, dimensions, geometric mean diameter, volume, sphericity index and the surface area. It was observed in the mechanical properties that moisture changes were effective at 1% on, maximum deformation, rupture force, rupture energy, toughness and the power to break. Loading speed was effective on maximum deformation, rupture force, rupture energy at 1% and it was effective on toughness at 5%. Loading orientation was effective on maximum deformation, rupture force, rupture energy, toughness at 1% and it was effective on power at 5%. The mutual effect of speed and orientation were effective on rupture energy at 1% and were effective on toughness at 5% probability. The mutual effect of moisture and speed were effective on rupture force and rupture energy at 1% and were effective on toughness 5% probability. The mutual effect of orientation and moisture on rupture energy and toughness were effective at 1%.

Keywords: Mechanical properties, Pea, Physical properties.

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2819 Comparison of Rheological Properties for Polymer Modified Asphalt Produced in Riyadh

Authors: Ali M. Babalghaith, Hamad A. Alsoliman, Abdulrahman S. Al-Suhaibani

Abstract:

Flexible pavement made with neat asphalt binder is not enough to resist heavy traffic loads as well as harsh environmental condition found in Riyadh region. Therefore, there is a need to modify asphalt binder with polymers to satisfy such conditions. There are several types of polymers that are used to modify asphalt binder. The objective of this paper is to compare the rheological properties of six polymer modified asphalt binders (Lucolast7010, Anglomak2144, Paveflex140, SBS KTR401, EE-2 and Crumb rubber) obtained from asphalt manufacturer plants. The rheological properties of polymer modified asphalt binders were tested using conventional tests such as penetration, softening point and viscosity; and SHRP tests such as dynamic shear rheometer and bending beam rheometer. The results have indicated that the polymer modified asphalt binders have lower penetration and higher softening point than neat asphalt indicating an improvement in stiffness of asphalt binder, and as a result, more resistant to rutting. Moreover, the dynamic shear rheometer results have shown that all modifiers used in this study improved the binder properties and satisfied the Superpave specifications except SBS KTR401 which failed to satisfy the rutting parameter (G*/sinδ).

Keywords: Polymer modified asphalt, rheological properties, SBS, crumb rubber, EE-2.

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2818 Full Potential Study of Electronic and Optical Properties of NdF3

Authors: Sapan Mohan Saini

Abstract:

We report the electronic structure and optical properties of NdF3 compound. Our calculations are based on density functional theory (DFT) using the full potential linearized augmented plane wave (FPLAPW) method with the inclusion of spin orbit coupling. We employed the local spin density approximation (LSDA) and Coulomb-corrected local spin density approximation, known for treating the highly correlated 4f electrons properly, is able to reproduce the correct insulating ground state. We find that the standard LSDA approach is incapable of correctly describing the electronic properties of such materials since it positions the f-bands incorrectly resulting in an incorrect metallic ground state. On the other hand, LSDA + U approximation, known for treating the highly correlated 4f electrons properly, is able to reproduce the correct insulating ground state. Interestingly, however, we do not find any significant differences in the optical properties calculated using LSDA, and LSDA + U suggesting that the 4f electrons do not play a decisive role in the optical properties of these compounds. The reflectivity for NdF3 compound stays low till 7 eV which is consistent with their large energy gaps. The calculated energy gaps are in good agreement with experiments. Our calculated reflectivity compares well with the experimental data and the results are analyzed in the light of band to band transitions.

Keywords: FPLAPW Method, optical properties, rare earthtrifluorides LSDA+U

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2817 Symmetries, Conservation Laws and Reduction of Wave and Gordon-type Equations on Riemannian Manifolds

Authors: Sameerah Jamal, Abdul Hamid Kara, Ashfaque H. Bokhari

Abstract:

Equations on curved manifolds display interesting properties in a number of ways. In particular, the symmetries and, therefore, the conservation laws reduce depending on how curved the manifold is. Of particular interest are the wave and Gordon-type equations; we study the symmetry properties and conservation laws of these equations on the Milne and Bianchi type III metrics. Properties of reduction procedures via symmetries, variational structures and conservation laws are more involved than on the well known flat (Minkowski) manifold.

Keywords: Bianchi metric, conservation laws, Milne metric, symmetries.

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2816 Gene Expressions Associated with Ultrastructural Changes in Vascular Endothelium of Atherosclerotic Lesion

Authors: M. Maimunah, G.A. Froemming, H. Nawawi, M.I. Nafeeza, O. Effat, M.R. Rohayu Izanwati, M.S. Mohamed Saifulaman

Abstract:

Attachment of the circulating monocytes to the endothelium is the earliest detectable events during formation of atherosclerosis. The adhesion molecules, chemokines and matrix proteases genes were identified to be expressed in atherogenesis. Expressions of these genes may influence structural integrity of the luminal endothelium. The aim of this study is to relate changes in the ultrastructural morphology of the aortic luminal surface and gene expressions of the endothelial surface, chemokine and MMP-12 in normal and hypercholesterolemic rabbits. Luminal endothelial surface from rabbit aortic tissue was examined by scanning electron microscopy (SEM) using low vacuum mode to ascertain ultrastructural changes in development of atherosclerotic lesion. Gene expression of adhesion molecules, MCP-1 and MMP-12 were studied by Real-time PCR. Ultrastructural observations of the aortic luminal surface exhibited changes from normal regular smooth intact endothelium to irregular luminal surface including marked globular appearance and ruptures of the membrane layer. Real-time PCR demonstrated differentially expressed of studied genes in atherosclerotic tissues. The appearance of ultrastructural changes in aortic tissue of hypercholesterolemic rabbits is suggested to have relation with underlying changes of endothelial surface molecules, chemokine and MMP-12 gene expressions.

Keywords: Ultrastructure of luminal endothelial surface, Macrophage metalloelastase (MMP-12), Real-time PCR.

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2815 Novel Solid Lipid Nanoparticles for Oral Delivery of Oxyresveratrol: Effect of the Formulation Parameters on the Physicochemical Properties and in vitro Release

Authors: Y. Sangsen, K. Likhitwitayawuid, B. Sritularak, K. Wiwattanawongsa, R. Wiwattanapatapee

Abstract:

Novel solid lipid nanoparticles (SLNs) were developed to improve oral bioavailability of oxyresveratrol (OXY). The SLNs were prepared by a high speed homogenization technique, at an effective speed and time, using Compritol® 888 ATO (5% w/w) as the solid lipid. The appropriate weight proportions (0.3% w/w) of OXY affected the physicochemical properties of blank SLNs. The effects of surfactant types on the properties of the formulations such as particle size and entrapment efficacy were also investigated. Conclusively, Tween 80 combined with soy lecithin was the most appropriate surfactant to stabilize OXY-loaded SLNs. The mean particle size of the optimized formulation was 134.40 ± 0.57 nm. In vitro drug release study, the selected S2 formulation showed a retarded release profile for OXY with no initial burst release compared to OXY suspension in the simulated gastrointestinal fluids. Therefore, these SLNs could provide a suitable system to develop for the oral OXY delivery.

Keywords: Solid lipid nanoparticles, Physicochemical properties, in vitro drug release, Oxyresveratrol.

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2814 Effect of Y Addition on the Microstructure and Mechanical Properties of Sn-Zn Eutectic Alloy

Authors: Jung-Ho Moon, Tae Kwon Ha

Abstract:

The effect of Yttrium addition on the microstructure and mechanical properties of Sn-Zn eutectic alloy, which has been attracting intensive focus as a Pb-free solder material, was investigated in this study. Phase equilibrium has been calculated by using FactSage® to evaluate the composition and fraction of equilibrium intermetallic compounds and construct a phase diagram. In the case of Sn-8.8Zn eutectic alloy, the as-cast microstructure was typical lamellar. With addition of 0.25wt.%Y, a large amount of pro-eutectic a phase have been observed and various YZnx intermetallic compounds were expected to successively form during cooling. Hardness of Sn-8.8Zn alloy was not affected by Y-addition and both alloys could be rolled by 90% at room temperature.

Keywords: Sn-Zn eutectic alloy, Yttrium, FactSage®, microstructure, mechanical properties.

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2813 Experimental Analysis of Mechanical Behavior under the Effect of Temperature Frequency

Authors: A. Nedjar, S. Aguib, M. Meloussi, T. Djedid, A. Khebli, R. Harhout, L. Kobzili, N. Chikh, M. Tourab

Abstract:

Finding the mechanical properties of magnetorheological elastomers (MREs) is fundamental to create smart materials and devices with desired properties and functionalities. The MREs properties, in shear mode, have been extensively investigated, but these have been less exploited with frequency-temperature dependence. In this article, we studied the performance of MREs with frequency-temperature dependence. The elastic modulus, loss modulus and loss factor of MREs were studied under different temperature values; different values of the magnetic field and different values of the frequency. The results found showed the interest of these active materials in different industrial sectors.

Keywords: Magnetorheological elastomer, mechanical behavior, frequency, temperature.

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2812 Changes in the Properties of Composites Caused by Chemical Treatment of Hemp Hurds

Authors: N. Stevulova, I. Schwarzova

Abstract:

The possibility of using industrial hemp as a source of natural fibers for purpose of construction, mainly for the preparation of lightweight composites based on hemp hurds is described. In this article, an overview of measurement results of important technical parameters (compressive strength, density, thermal conductivity) of composites based on organic filler - chemically modified hemp hurds in three solutions (EDTA, NaOH and Ca(OH)2) and inorganic binder MgO-cement after 7, 28, 60, 90 and 180 days of hardening is given. The results of long-term water storage of 28 days hardened composites at room temperature were investigated. Changes in the properties of composites caused by chemical treatment of hemp material are discussed.

Keywords: Hemp hurds, chemical modification, lightweight composites, testing material properties.

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2811 Effect of Zr Addition on Mechanical Properties of Cr-Mo Plastic Mold Steels

Authors: Hyun-Ho Kim, Seok-Jae Lee, Oh-Yeon Lee

Abstract:

We investigated the effects of the additions of Zr and other alloying elements on the mechanical properties and microstructure in Cr-Mo plastic mold steels. The addition of alloying elements changed the microstructure of the normalized samples from the upper bainite to lower bainite due to the increased hardenability. The tempering temperature influenced the strength and hardness values, especially the phenomenon of 350oC embrittlement was observed. The alloy additions of Cr, Mo, and V improved the resistance to the temper embrittlement. The addition of Zr improved the tensile strength and yield strength, but the impact energy was sharply decreased. It may be caused by the formation of Zr-MnS inclusion and rectangular-shaped Zr inclusion due to the Zr addition.

Keywords: Inclusions, mechanical properties, plastic mold steel, Zr addition.

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2810 Assessment of Diagnostic Enzymes as Indices of Heavy Metal Pollution in Tilapia Fish

Authors: Justina I. R. Udotong

Abstract:

Diagnostic enzymes like aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were determined as indices of heavy metal pollution in Tilapia guinensis. Three different sets of fishes treated with lead (Pb), iron (Fe) and copper (Cu) were used for the study while a fourth group with no heavy metal served as a control. Fishes in each of the groups were exposed to 2.65mg/l of Pb, 0.85mg/l of Fe and 0.35 mg/l of Cu in aerated aquaria for 96 hours. Tissue fractionation of the liver tissues was carried out and the three diagnostic enzymes (AST, ALT, and ALP) were estimated. Serum levels of the same diagnostic enzymes were also measured. The mean values of the serum enzyme activity for ALP in each experimental group were 19.5±1.62, 29.67±2.17 and 1.15±0.27 IU/L for Pb, Fe and Cu groups compared with 9.99±1.34 IU/L enzyme activity in the control. This result showed that Pb and Fe caused increased release of the enzyme into the blood circulation indicating increased tissue damage while Cu caused a reduction in the serum level as compared with the level in the control group. The mean values of enzyme activity obtained in the liver were 102.14±6.12, 140.17±2.06 and 168.23±3.52 IU/L for Pb, Fe and Cu groups, respectively compared to 91.20±9.42 IU/L enzyme activity for the control group. The serum and liver AST and ALT activities obtained in Pb, Fe, Cu and control groups are reported. It was generally noted that the presence of the heavy metal caused liver tissues damage and consequent increased level of the diagnostic enzymes in the serum.

Keywords: Diagnostic enzymes, enzyme activity, heavy metals, tissues investigations.

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2809 Microstructure, Mechanical, Electrical and Thermal Properties of the Al-Si-Ni Ternary Alloy

Authors: Aynur Aker, Hasan Kaya

Abstract:

In recent years, the use of the aluminum based alloys in the industry and technology are increasing. Alloying elements in aluminum have further been improving the strength and stiffness properties that provide superior compared to other metals. In this study, investigation of physical properties (microstructure, microhardness, tensile strength, electrical conductivity and thermal properties) in the Al-12.6wt.%Si-%2wt.Ni ternary alloy were investigated. Al-Si-Ni alloy was prepared in vacuum atmosphere. The samples were directionally solidified upwards with different growth rate V (8.3−165.45 μm/s) at constant temperature gradient G (7.73 K/mm). The flake spacings (λ), microhardness (HV), ultimate tensile strength (σ), electrical resistivity (ρ) and thermal properties (H, Cp, Tm) of the samples were measured. Influence of the growth rate and spacings on microhardness, ultimate tensile strength and electrical resistivity were investigated and relationships between them were obtained. According to results, λ values decrease with increasing V, but HV, σ and ρ values increase with increasing V. Variations of electrical resistivity (ρ) of solidified samples were also measured. The enthalpy of fusion (H) and specific heat (Cp) for the alloy was also determined by differential scanning calorimeter (DSC) from heating trace during the transformation from liquid to solid. The results in this work were compared with the previous similar experimental results.

Keywords: Electrical resistivity, enthalpy, microhardness, solidification, tensile stress.

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2808 ATR-IR Study of the Mechanism of Aluminum Chloride Induced Alzheimer’s Disease; Curative and Protective Effect of Lipidium sativum Water Extract on Hippocampus Rats Brain Tissue

Authors: Maha Jameal Balgoon, Gehan A. Raouf, Safaa Y. Qusti, Soad Shaker Ali

Abstract:

The main cause of Alzheimer disease (AD) was believed to be mainly due to the accumulation of free radicals owing to oxidative stress (OS) in brain tissue. The mechanism of the neurotoxicity of Aluminum chloride (AlCl3) induced AD in hippocampus Albino wister rat brain tissue, the curative & the protective effects of Lipidium sativum group (LS) water extract were assessed after 8 weeks by attenuated total reflection spectroscopy ATR-IR and histologically by light microscope. ATR-IR results revealed that the membrane phospholipid undergo free radical attacks, mediated by AlCl3, primary affects the polyunsaturated fatty acids indicated by the increased of the olefinic -C=CH sub-band area around 3012 cm-1 from the curve fitting analysis. The narrowing in the half band width (HBW) of the sνCH2 sub-band around 2852 cm-1 due to Al intoxication indicates the presence of trans form fatty acids rather than gauch rotomer. The degradation of hydrocarbon chain to shorter chain length, increasing in membrane fluidity, disorder, and decreasing in lipid polarity in AlCl3 group indicated by the detected changes in certain calculated area ratios compared to the control. Administration of LS was greatly improved these parameters compared to the AlCl3 group. Al influences the Aβ aggregation and plaque formation, which in turn interferes to and disrupts the membrane structure. The results also showed a marked increase in the β-parallel and antiparallel structure, that characterize the Aβ formation in Al-induced AD hippocampal brain tissue, indicated by the detected increase in both amide I sub-bands around 1674, 1692 cm-1. This drastic increase in Aβ formation was greatly reduced in the curative and protective groups compared to the AlCl3 group and approached nearly the control values. These results supported too by the light microscope. AlCl3 group showed significant marked degenerative changes in hippocampal neurons. Most cells appeared small, shrieked and deformed. Interestingly, the administration of LS in curative and protective groups markedly decreases the amount of degenerated cells compared to the non-treated group. In addition, the intensity of congo red stained cells was decreased. Hippocampal neurons looked more/or less similar to those of control. This study showed a promising therapeutic effect of Lipidium sativum group (LS) on AD rat model that seriously overcome the signs of oxidative stress on membrane lipid and restore the protein misfolding.

Keywords: Aluminum chloride, Alzheimer’s disease, ATR-IR, Lipidium sativum.

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