%0 Journal Article
	%A Hadi Hasanzadeh and  Manijhe Mokhtari-Dizaji and  S.Zahra Bathaie and  Zuhair M. Hassan and  Hamid R. Miri and  Mahbobe Alamolhoda and  Vahid Nilchiani and  Hamid Goudarzi
	%D 2010
	%J International Journal of Pharmacological and Pharmaceutical Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 45, 2010
	%T Effect of Local Dual Frequency Sonication on Drug Distribution from Nanomicelles
	%U https://publications.waset.org/pdf/8608
	%V 45
	%X The nanosized polymeric micelles release the drug
due to acoustic cavitation, which is enhanced in dual frequency
ultrasonic fields. In this study, adult female Balb/C mice were
transplanted with spontaneous breast adenocarcinoma tumors and
were injected with a dose of 1.3 mg/kg doxorubicin in one of three
forms: free doxorubicin, micellar doxorubicin without sonication and
micellar doxorubicin with sonication. To increase cavitation yield,
the tumor region was sonicated with low level dual frequency of 3
MHz and 28 kHz. The animals were sacrificed 24 h after injection,
and their tumor, heart, spleen, liver, kidneys and plasma were
separated and homogenized. The drug content in their tumor, heart,
spleen, liver, kidneys and plasma was determined using tissue
fluorimetry. The results show that in the group that received micellar
doxorubicin with sonication, the drug concentration in the tumor
tissue was nine and three times higher than in the free doxorubicin
group and the micellar doxorubicin without sonication group,
respectively. In the micellar doxorubicin with sonication group, the
drug concentration in other tissues was lower than other groups
	%P 503 - 507