Search results for: W. T. Chong
9 A Pairwise-Gaussian-Merging Approach: Towards Genome Segmentation for Copy Number Analysis
Authors: Chih-Hao Chen, Hsing-Chung Lee, Qingdong Ling, Hsiao-Jung Chen, Sun-Chong Wang, Li-Ching Wu, H.C. Lee
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Segmentation, filtering out of measurement errors and identification of breakpoints are integral parts of any analysis of microarray data for the detection of copy number variation (CNV). Existing algorithms designed for these tasks have had some successes in the past, but they tend to be O(N2) in either computation time or memory requirement, or both, and the rapid advance of microarray resolution has practically rendered such algorithms useless. Here we propose an algorithm, SAD, that is much faster and much less thirsty for memory – O(N) in both computation time and memory requirement -- and offers higher accuracy. The two key ingredients of SAD are the fundamental assumption in statistics that measurement errors are normally distributed and the mathematical relation that the product of two Gaussians is another Gaussian (function). We have produced a computer program for analyzing CNV based on SAD. In addition to being fast and small it offers two important features: quantitative statistics for predictions and, with only two user-decided parameters, ease of use. Its speed shows little dependence on genomic profile. Running on an average modern computer, it completes CNV analyses for a 262 thousand-probe array in ~1 second and a 1.8 million-probe array in 9 secondsKeywords: Cancer, pathogenesis, chromosomal aberration, copy number variation, segmentation analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14778 Bridging Stress Modeling of Composite Materials Reinforced by Fibers Using Discrete Element Method
Authors: Chong Wang, Kellem M. Soares, Luis E. Kosteski
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The problem of toughening in brittle materials reinforced by fibers is complex, involving all of the mechanical properties of fibers, matrix and the fiber/matrix interface, as well as the geometry of the fiber. Development of new numerical methods appropriate to toughening simulation and analysis is necessary. In this work, we have performed simulations and analysis of toughening in brittle matrix reinforced by randomly distributed fibers by means of the discrete elements method. At first, we put forward a mechanical model of toughening contributed by random fibers. Then with a numerical program, we investigated the stress, damage and bridging force in the composite material when a crack appeared in the brittle matrix. From the results obtained, we conclude that: (i) fibers of high strength and low elasticity modulus are beneficial to toughening; (ii) fibers of relatively high elastic modulus compared to the matrix may result in substantial matrix damage due to spalling effect; (iii) employment of high-strength synthetic fibers is a good option for toughening. We expect that the combination of the discrete element method (DEM) with the finite element method (FEM) can increase the versatility and efficiency of the software developed. The present work can guide the design of ceramic composites of high performance through the optimization of the parameters.
Keywords: Bridging stress, discrete element method, fiber reinforced composites, toughening.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19007 Research of Strong-Column-Weak-Beam Criteria of Reinforced Concrete Frames Subjected to Biaxial Seismic Excitation
Authors: Chong Zhang, Mu-Xuan Tao
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In several earthquakes, numerous reinforced concrete (RC) frames subjected to seismic excitation demonstrated a collapse pattern characterized by column hinges, though designed according to the Strong-Column-Weak-Beam (S-C-W-B) criteria. The effect of biaxial seismic excitation on the disparity between design and actual performance is carefully investigated in this article. First, a modified load contour method is proposed to derive a closed-form equation of biaxial bending moment strength, which is verified by numerical and experimental tests. Afterwards, a group of time history analyses of a simple frame modeled by fiber beam-column elements subjected to biaxial seismic excitation are conducted to verify that the current S-C-W-B criteria are not adequate to prevent the occurrence of column hinges. A biaxial over-strength factor is developed based on the proposed equation, and the reinforcement of columns is appropriately amplified with this factor to prevent the occurrence of column hinges under biaxial excitation, which is proved to be effective by another group of time history analyses.
Keywords: Biaxial bending moment strength, biaxial seismic excitation, fiber beam-column model, load contour method, strong-column-weak-beam.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6226 Augmented Reality for Maintenance Operator for Problem Inspections
Authors: Chong-Yang Qiao, Teeravarunyou Sakol
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Current production-oriented factories need maintenance operators to work in shifts monitoring and inspecting complex systems and different equipment in the situation of mechanical breakdown. Augmented reality (AR) is an emerging technology that embeds data into the environment for situation awareness to help maintenance operators make decisions and solve problems. An application was designed to identify the problem of steam generators and inspection centrifugal pumps. The objective of this research was to find the best medium of AR and type of problem solving strategies among analogy, focal object method and mean-ends analysis. Two scenarios of inspecting leakage were temperature and vibration. Two experiments were used in usability evaluation and future innovation, which included decision-making process and problem-solving strategy. This study found that maintenance operators prefer build-in magnifier to zoom the components (55.6%), 3D exploded view to track the problem parts (50%), and line chart to find the alter data or information (61.1%). There is a significant difference in the use of analogy (44.4%), focal objects (38.9%) and mean-ends strategy (16.7%). The marked differences between maintainers and operators are of the application of a problem solving strategy. However, future work should explore multimedia information retrieval which supports maintenance operators for decision-making.Keywords: Augmented reality, situation awareness, decision-making, problem-solving.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13455 Removal of Ni(II), Zn(II) and Pb(II) ions from Single Metal Aqueous Solution using Activated Carbon Prepared from Rice Husk
Authors: Mohd F. Taha, Chong F. Kiat, Maizatul S. Shaharun, Anita Ramli
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The abundance and availability of rice husk, an agricultural waste, make them as a good source for precursor of activated carbon. In this work, rice husk-based activated carbons were prepared via base treated chemical activation process prior the carbonization process. The effect of carbonization temperatures (400, 600 and 800oC) on their pore structure was evaluated through morphology analysis using scanning electron microscope (SEM). Sample carbonized at 800oC showed better evolution and development of pores as compared to those carbonized at 400 and 600oC. The potential of rice husk-based activated carbon as an alternative adsorbent was investigated for the removal of Ni(II), Zn(II) and Pb(II) from single metal aqueous solution. The adsorption studies using rice husk-based activated carbon as an adsorbent were carried out as a function of contact time at room temperature and the metal ions were analyzed using atomic absorption spectrophotometer (AAS). The ability to remove metal ion from single metal aqueous solution was found to be improved with the increasing of carbonization temperature. Among the three metal ions tested, Pb(II) ion gave the highest adsorption on rice husk-based activated carbon. The results obtained indicate the potential to utilize rice husk as a promising precursor for the preparation of activated carbon for removal of heavy metals.
Keywords: Activated carbon, metal ion adsorption, rice husk, wastewater treatment.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27174 Modeling and Visualizing Seismic Wave Propagation in Elastic Medium Using Multi-Dimension Wave Digital Filtering Approach
Authors: Jason Chien-Hsun Tseng, Nguyen Dong-Thai Dao, Chong-Ching Chang
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A novel PDE solver using the multidimensional wave digital filtering (MDWDF) technique to achieve the solution of a 2D seismic wave system is presented. In essence, the continuous physical system served by a linear Kirchhoff circuit is transformed to an equivalent discrete dynamic system implemented by a MD wave digital filtering (MDWDF) circuit. This amounts to numerically approximating the differential equations used to describe elements of a MD passive electronic circuit by a grid-based difference equations implemented by the so-called state quantities within the passive MDWDF circuit. So the digital model can track the wave field on a dense 3D grid of points. Details about how to transform the continuous system into a desired discrete passive system are addressed. In addition, initial and boundary conditions are properly embedded into the MDWDF circuit in terms of state quantities. Graphic results have clearly demonstrated some physical effects of seismic wave (P-wave and S–wave) propagation including radiation, reflection, and refraction from and across the hard boundaries. Comparison between the MDWDF technique and the finite difference time domain (FDTD) approach is also made in terms of the computational efficiency.Keywords: Seismic Wave Propagation, Multi-dimension WaveDigital Filters, Partial Differential Equations.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14353 Mobile Augmented Reality for Collaboration in Operation
Authors: Chong-Yang Qiao
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Mobile augmented reality (MAR) tracking targets from the surroundings and aids operators for interactive data and procedures visualization, potential equipment and system understandably. Operators remotely communicate and coordinate with each other for the continuous tasks, information and data exchange between control room and work-site. In the routine work, distributed control system (DCS) monitoring and work-site manipulation require operators interact in real-time manners. The critical question is the improvement of user experience in cooperative works through applying Augmented Reality in the traditional industrial field. The purpose of this exploratory study is to find the cognitive model for the multiple task performance by MAR. In particular, the focus will be on the comparison between different tasks and environment factors which influence information processing. Three experiments use interface and interaction design, the content of start-up, maintenance and stop embedded in the mobile application. With the evaluation criteria of time demands and human errors, and analysis of the mental process and the behavior action during the multiple tasks, heuristic evaluation was used to find the operators performance with different situation factors, and record the information processing in recognition, interpretation, judgment and reasoning. The research will find the functional properties of MAR and constrain the development of the cognitive model. Conclusions can be drawn that suggest MAR is easy to use and useful for operators in the remote collaborative works.Keywords: Mobile augmented reality, remote collaboration, user experience, cognitive model.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13382 The Changing Trend of Collaboration Patterns in the Social Sciences: Institutional Influences on Academic Research in Korea, 2013-2016
Authors: Ho-Dae Chong, Jong-Kil Kim
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Collaborative research has become more prevalent and important across disciplines because it stimulates innovation and interaction between scholars. Seeing as existing studies relatively disregarded the institutional conditions triggering collaborative research, this work aims to analyze the changing trend in collaborative work patterns among Korean social scientists. The focus of this research is the performance of social scientists who received research grants through the government’s Social Science Korea (SSK) program. Using quantitative statistical methods, collaborative research patterns in a total of 2,354 papers published under the umbrella of the SSK program in peer-reviewed scholarly journals from 2013 to 2016 were examined to identify changing trends and triggering factors in collaborative research. A notable finding is that the share of collaborative research is overwhelmingly higher than that of individual research. In particular, levels of collaborative research surpassed 70%, increasing much quicker compared to other research done in the social sciences. Additionally, the most common composition of collaborative research was for two or three researchers to conduct joint research as coauthors, and this proportion has also increased steadily. Finally, a strong association between international journals and co-authorship patterns was found for the papers published by SSK program researchers from 2013 to 2016. The SSK program can be seen as the driving force behind collaboration between social scientists. Its emphasis on competition through a merit-based financial support system along with a rigorous evaluation process seems to have influenced researchers to cooperate with those who have similar research interests.
Keywords: Co-authorship, collaboration, competition, cooperation, Social Science Korea, policy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 9841 Evaluation of Chiller Power Consumption Using Grey Prediction
Authors: Tien-Shun Chan, Yung-Chung Chang, Cheng-Yu Chu, Wen-Hui Chen, Yuan-Lin Chen, Shun-Chong Wang, Chang-Chun Wang
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98% of the energy needed in Taiwan has been imported. The prices of petroleum and electricity have been increasing. In addition, facility capacity, amount of electricity generation, amount of electricity consumption and number of Taiwan Power Company customers have continued to increase. For these reasons energy conservation has become an important topic. In the past linear regression was used to establish the power consumption models for chillers. In this study, grey prediction is used to evaluate the power consumption of a chiller so as to lower the total power consumption at peak-load (so that the relevant power providers do not need to keep on increasing their power generation capacity and facility capacity). In grey prediction, only several numerical values (at least four numerical values) are needed to establish the power consumption models for chillers. If PLR, the temperatures of supply chilled-water and return chilled-water, and the temperatures of supply cooling-water and return cooling-water are taken into consideration, quite accurate results (with the accuracy close to 99% for short-term predictions) may be obtained. Through such methods, we can predict whether the power consumption at peak-load will exceed the contract power capacity signed by the corresponding entity and Taiwan Power Company. If the power consumption at peak-load exceeds the power demand, the temperature of the supply chilled-water may be adjusted so as to reduce the PLR and hence lower the power consumption.Keywords: Gery system theory, grey prediction, chller.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2580