Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 32759
Novel Process Formulation of Multiple Unit Tablet of Pantoprazole

Authors: Vipin Saini, Sunil Kamboj, Suman Bala, A. Pandurangan

Abstract:

The present invention relates to multiple-unit tablet dosage forms, which is composed of several subunits (multiparticulates/pellets). Each small multiparticulate further composed of many layers. Some layer contains drug substance; others are rate controlling polymer. The resulting multiple-unit tablet dosage forms of pantoprazole were satisfactory fabricated. Pelletization technique has some advantages over coated tablet formulation. In coated tablet the coating may be damaged and a pinhole possibly formed that would result in increased release of drug in stomach and may be deactivated in stomach juices. If the coat of some pellets may be damaged that would not affect the release properties of the multiple-unit tablet. Hence they are beneficial in this aspect. The results confirmed the successful preparation of stable and bioequivalent once daily controlled release multiple-unit tablets of pantoprazole.

Keywords: Controlled release, multiple unit tablets, pantoprazole, pelletization.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1087756

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References:


[1] L. Asghar, “Multiparticulate formulation approach to colon specific drug delivery: current perspectives,” J. Pharm. Pharma. Sci., vol. 9, no. 3, pp. 327-338, 2006.
[2] Breitenbach, “Melt Spheronization: from process to drug delivery technology,” Eur. J. Pharm. Biopharm., vol. 54, pp. 107-117, 2002.
[3] M. Cespi, “Stress relaxation test for the characterization of viscoelasticity of pellets,” Eur. J. Pharm. Biopharm., vol. 67, no. 2, pp. 476-484, 2007.
[4] A. Dashevsky, “Compression of pellets coated with various aqueous polymer dispersion,” Int. J. Pharm., vol. 279, pp.19-26, 2004.
[5] K. Dashora, “Spectrophotometric estimation of aceclofenac in pharmaceutical dosage forms,” Biosci. Biotech. Res. Asia, vol. 3, pp. 277-278, 2006.
[6] S. Jessy, “Novel approaches in multiparticulates drug delivery systems,” The Indian Pharmacist, pp. 21-28, 2007.
[7] O. M. Y. Koo, “The influence of microcrystalline cellulose grade on shape and shape distribution of pellets produced by extrusionspheronization,” Chem. Pharm. Bull., vol. 49, no. 11, pp. 1383-1387, 2001.
[8] A. E. K. Lundqvist, “Compaction of, and drug release from, coated drug pellets mixed with other pellets,” Eur. J. Pharm. Biopharm., vol. 46, pp.369-379, 2005.
[9] J. Moschwitzer, “Spray coated pellets as a carrier system for mucoadhesive drug nanocrystals. Eur. J. Pharm. Biopharm., vol. 62, pp. 282-287, 2005.
[10] S. Mutalik, “Prepration in vitro, preclinical evaluation of once daily sustained release tablets of aceclofenac,” Arch. Pharm. Res., vol. 2, no. 30, pp. 222-234, 2007