{"title":"Novel Process Formulation of Multiple Unit Tablet of Pantoprazole","authors":"Vipin Saini, Sunil Kamboj, Suman Bala, A. Pandurangan","volume":81,"journal":"International Journal of Pharmacological and Pharmaceutical Sciences","pagesStart":574,"pagesEnd":580,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/16694","abstract":"
The present invention relates to multiple-unit tablet dosage forms, which is composed of several subunits (multiparticulates\/pellets). Each small multiparticulate further composed of many layers. Some layer contains drug substance; others are rate controlling polymer. The resulting multiple-unit tablet dosage forms of pantoprazole were satisfactory fabricated. Pelletization technique has some advantages over coated tablet formulation. In coated tablet the coating may be damaged and a pinhole possibly formed that would result in increased release of drug in stomach and may be deactivated in stomach juices. If the coat of some pellets may be damaged that would not affect the release properties of the multiple-unit tablet. Hence they are beneficial in this aspect. The results confirmed the successful preparation of stable and bioequivalent once daily controlled release multiple-unit tablets of pantoprazole.<\/p>\r\n","references":"[1] L. Asghar, \u201cMultiparticulate formulation approach to colon specific drug\r\ndelivery: current perspectives,\u201d J. Pharm. Pharma. Sci., vol. 9, no. 3, pp.\r\n327-338, 2006.\r\n[2] Breitenbach, \u201cMelt Spheronization: from process to drug delivery\r\ntechnology,\u201d Eur. J. Pharm. Biopharm., vol. 54, pp. 107-117, 2002.\r\n[3] M. Cespi, \u201cStress relaxation test for the characterization of\r\nviscoelasticity of pellets,\u201d Eur. J. Pharm. Biopharm., vol. 67, no. 2, pp.\r\n476-484, 2007.\r\n[4] A. Dashevsky, \u201cCompression of pellets coated with various aqueous\r\npolymer dispersion,\u201d Int. J. Pharm., vol. 279, pp.19-26, 2004.\r\n[5] K. Dashora, \u201cSpectrophotometric estimation of aceclofenac in\r\npharmaceutical dosage forms,\u201d Biosci. Biotech. Res. Asia, vol. 3, pp.\r\n277-278, 2006.\r\n[6] S. Jessy, \u201cNovel approaches in multiparticulates drug delivery systems,\u201d\r\nThe Indian Pharmacist, pp. 21-28, 2007.\r\n[7] O. M. Y. Koo, \u201cThe influence of microcrystalline cellulose grade on\r\nshape and shape distribution of pellets produced by extrusionspheronization,\u201d\r\nChem. Pharm. Bull., vol. 49, no. 11, pp. 1383-1387,\r\n2001.\r\n[8] A. E. K. Lundqvist, \u201cCompaction of, and drug release from, coated drug\r\npellets mixed with other pellets,\u201d Eur. J. Pharm. Biopharm., vol. 46,\r\npp.369-379, 2005.\r\n[9] J. Moschwitzer, \u201cSpray coated pellets as a carrier system for\r\nmucoadhesive drug nanocrystals. Eur. J. Pharm. Biopharm., vol. 62, pp.\r\n282-287, 2005.\r\n[10] S. Mutalik, \u201cPrepration in vitro, preclinical evaluation of once daily\r\nsustained release tablets of aceclofenac,\u201d Arch. Pharm. Res., vol. 2, no.\r\n30, pp. 222-234, 2007","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 81, 2013"}