Vipin Saini and Sunil Kamboj and Suman Bala and A. Pandurangan
Novel Process Formulation of Multiple Unit Tablet of Pantoprazole
574 - 579
2013
7
9
International Journal of Pharmacological and Pharmaceutical Sciences
https://publications.waset.org/pdf/16694
https://publications.waset.org/vol/81
World Academy of Science, Engineering and Technology
The present invention relates to multipleunit tablet dosage forms, which is composed of several subunits (multiparticulatespellets). Each small multiparticulate further composed of many layers. Some layer contains drug substance; others are rate controlling polymer. The resulting multipleunit tablet dosage forms of pantoprazole were satisfactory fabricated. Pelletization technique has some advantages over coated tablet formulation. In coated tablet the coating may be damaged and a pinhole possibly formed that would result in increased release of drug in stomach and may be deactivated in stomach juices. If the coat of some pellets may be damaged that would not affect the release properties of the multipleunit tablet. Hence they are beneficial in this aspect. The results confirmed the successful preparation of stable and bioequivalent once daily controlled release multipleunit tablets of pantoprazole.
Open Science Index 81, 2013