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Coupled Multifield Analysis of Piezoelectrically Actuated Microfluidic Device for Transdermal Drug Delivery Applications
Abstract:In this paper, design, fabrication and coupled multifield analysis of hollow out-of-plane silicon microneedle array with piezoelectrically actuated microfluidic device for transdermal drug delivery (TDD) applications is presented. The fabrication process of silicon microneedle array is first done by series of combined isotropic and anisotropic etching processes using inductively coupled plasma (ICP) etching technology. Then coupled multifield analysis of MEMS based piezoelectrically actuated device with integrated 2×2 silicon microneedle array is presented. To predict the stress distribution and model fluid flow in coupled field analysis, finite element (FE) and computational fluid dynamic (CFD) analysis using ANSYS rather than analytical systems has been performed. Static analysis and transient CFD analysis were performed to predict the fluid flow through the microneedle array. The inlet pressure from 10 kPa to 150 kPa was considered for static CFD analysis. In the lumen region fluid flow rate 3.2946 μL/min is obtained at 150 V for 2×2 microneedle array. In the present study the authors have performed simulation of structural, piezoelectric and CFD analysis on three dimensional model of the piezoelectrically actuated mcirofluidic device integrated with 2×2 microneedle array.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1070241Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1456
 B. Barry, and A. Williams, "Penetration enhancers", Adv. Drug Deliv. Rev., Vol.56, pp. 603-618, 2003.
 V. Preat, and R. Vanbever " Skin electroporation for Transdermal and topical delivery", ", Adv. Drug Deliv. Rev., Vol.56, pp. 659-674, 2004.
 Jing Ji, F. Tay. And J. Miao, "Microfabricated Hollow Microneedle Array Using ICP Etcher", Journal of Physics, Confirence series 34, pp. 1132-136, 2006.
 Gerstel et al., Drug Delivery Device, US 3 964 482 patent, 1976.
 Mark R. Prausnitz," Microneedles for transdermal drug delivery", Adv. Drug Deliv. Rev. 56, pp. 581-587, 2004.
 P. Griss, and G. Stemme, "Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer", J. Microelectromechanical Sys, 12 (3), pp. 296-301, 2003.
 E.V. Mukerjee, R. Issseroff, S. D. Collins, and R.L. Smith, "Microneedle array with integrated microchannels for transdermal sample extraction and in situ analysis", The 12th International Conference on Solid State Sensors, Actuators and Microsystems, pp. 1439-1441, Boston, 8-12 June 2003.
 N. Wilke , C. Hibert, J. O-Brien, and A. Morrissey, "Silicon microneedle electrode array with temperature monitoring for electroporation", Sensors and Actuators A 123-124, pp. 319-325, 2005.
 Z. Jeffrey, T. David, and L. Dorian, "Microdialysis Microneedles for Continuous Medical Monitoring", Biomedical Microdevices 7, pp. 59- 69, 2005.
 M. Bin, L. Sheng, G. Zhiyin, L. Guojun, C. Xinxia, Z. Honghai, and Y. Zhigang, "A PZT insulin pump integrated with silicon microneedle array for transdermal drug delivery", Microfluid Nanofluid 2, pp.417-423, 2006.
 N. Roxhed, "A fully integrated microneedle based transdermal drug delivery system", A PhD thesis, Microsystems Technology Laboratory, Royal Institute of Technology, Sweden, 2007.
 J. D. Zahn, N. H. Talbot, D. Liepman, and A. P. Pisano, " microfbricated polysilicon microneedles for minimally invasive biomedical devices", Biomed, Microdevices 2,pp. 295-303, 2000.
 J. Gere, S Timoshenko, Mechanics of materials, Fourth ed., May 1997
 W.S. Janna," Design of fluid thermal system", 2nd edn. PWS Publications, Boston, 1998.
 D. W. Bodjale, A. Nisar, and N. Afzulpurkar, "structural and microfludic analysis of hollow side open polymeric microneedles for transdermal drug delivery applications", Microfluid Nanofluid, 2009.
 S. Khumpuang, R. Maeda, and S. Sugiyama, "Design and fabrication of coupled microneedle array and insertion guide array for safe penetration through skin"; International symposium of micromechatronics and human science, 2003.
 M. W. Ashraf, S. Tayyaba, A. Nisar, N. Afzulpurkar, and A. Tuantranont , "Coupledfield Microfluidic Analysis of Integrated MEMS Based Device for Transdermal Drug Delivery Applications", In: 13th IEEE Multitopic Int. Conf. Islamabad, Pakistan, December 14-15, 2009.