Commenced in January 2007
Paper Count: 32321
Features of the Immune Response in Mice were Immunized with Polio Vaccine in Combination with Chitosan Preparations as Adjuvants
Authors: Nelly К. Akhmatova, Оlga V. Lebedinskaya, Stanislav G. Markushin, Elvin А. Akhmatov, Lidiya A. Geiderova, Еlena А. Lebedinskaya, Vera M. Axenova, Аnatoliy P. Godovalov
Abstract:The study of cytokine expression in mice under the influence of inactivated poliovirus and Imovaks polio vaccine in combination with derivatives of chitosan shows various kinds of processes. There is a significant increase in IL-12 in the serum of immunized animals, which should stimulate the production of IFN-γ NK-cells and T-cells and polarize the immune response to Th1 type. Thus, the derivatives of chitosan can promote cell component of the immune response, providing a full antiviral immunity.
Keywords: Poliovirus, chitosan, cytokine expression, antiviral immunity.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1335304Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1756
 L. Casettari, E. Castagnino, S. Stolnik, A. Lewis, S.M. Howdle, L. Illum "Surface characterisation of bioadhesive PLGA/chitosan microparticles produced by supercritical fluid technology", Pharm. Res., vol. 28(7), 2011, pp. 1668-1682.
 M.J. Heffernan, D.A. Zaharoff, J.K. Fallon, J. Schlom, J.W. Greiner "In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines", Biomaterials, vol. 32(3), 2011, pp. 926-932.
 C. Prego, Paolicelly Pr Diaz B. "Chitosan-based nanoparticles for improving imunization against hepatitis infection", Vaccine, vol. 28, 2010, pp. 2607-2614.
 Zheng-Shun Wen, Ying-Lei Xu, Xiao-Ting Zou, Zi-Rong Xu "Chitosan Nanoparticles Act as an Adjuvant to Promote both Th1 and Th2 Immune Responses Induced by Ovalbumin in Mice", Mar. Drugs., vol. 9(6), 2011, pp. 1038-1055.