Features of the Immune Response in Mice were Immunized with Polio Vaccine in Combination with Chitosan Preparations as Adjuvants

Authors: Nelly К. Akhmatova, Оlga V. Lebedinskaya, Stanislav G. Markushin, Elvin А. Akhmatov, Lidiya A. Geiderova, Еlena А. Lebedinskaya, Vera M. Axenova, Аnatoliy P. Godovalov

Abstract:

The study of cytokine expression in mice under the influence of inactivated poliovirus and Imovaks polio vaccine in combination with derivatives of chitosan shows various kinds of processes. There is a significant increase in IL-12 in the serum of immunized animals, which should stimulate the production of IFN-γ NK-cells and T-cells and polarize the immune response to Th1 type. Thus, the derivatives of chitosan can promote cell component of the immune response, providing a full antiviral immunity.

Keywords: Poliovirus, chitosan, cytokine expression, antiviral immunity.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1335304

References:

[1] L. Casettari, E. Castagnino, S. Stolnik, A. Lewis, S.M. Howdle, L. Illum "Surface characterisation of bioadhesive PLGA/chitosan microparticles produced by supercritical fluid technology", Pharm. Res., vol. 28(7), 2011, pp. 1668-1682.
[2] M.J. Heffernan, D.A. Zaharoff, J.K. Fallon, J. Schlom, J.W. Greiner "In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines", Biomaterials, vol. 32(3), 2011, pp. 926-932.
[3] C. Prego, Paolicelly Pr Diaz B. "Chitosan-based nanoparticles for improving imunization against hepatitis infection", Vaccine, vol. 28, 2010, pp. 2607-2614.
[4] Zheng-Shun Wen, Ying-Lei Xu, Xiao-Ting Zou, Zi-Rong Xu "Chitosan Nanoparticles Act as an Adjuvant to Promote both Th1 and Th2 Immune Responses Induced by Ovalbumin in Mice", Mar. Drugs., vol. 9(6), 2011, pp. 1038-1055.