Commenced in January 2007
Paper Count: 32009
Increase of Sensitivity in 3D Suspended Polymeric Microfluidic Platform through Lateral Misalignment
Abstract:In the present study, a design of the suspended polymeric microfluidic platform is introduced that is fabricated with three polymeric layers. Changing the microchannel plane to be perpendicular to microcantilever plane, drastically decreases moment of inertia in that direction. In addition, the platform is made of polymer (around five orders of magnitude less compared to silicon). It causes significant increase in the sensitivity of the cantilever deflection. Next, although the dimensions of this platform are constant, by misaligning the embedded microchannels laterally in the suspended microfluidic platform, the sensitivity can be highly increased. The investigation is studied on four fluids including water, seawater, milk, and blood for flow ranges from low rate of 5 to 70 µl/min to obtain the best design with the highest sensitivity. The best design in this study shows the sensitivity increases around 50% for water, seawater, milk, and blood at the flow rate of 70 µl/min by just misaligning the embedded microchannels in the suspended polymeric microfluidic platform.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1314799Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 716
 Watari, Moyu, et al. "Investigating the molecular mechanisms of in-plane mechanochemistry on cantilever arrays." Journal of the American Chemical Society 129.3 (2007): 601-609.
 Huber, François, et al. "Label free analysis of transcription factors using microcantilever arrays." Biosensors and Bioelectronics 21.8 (2006): 1599-1605.
 Mertens, Johann, et al. "Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films." Nature nanotechnology 3.5 (2008): 301-307.
 Wu, Guanghua, et al. "Origin of nanomechanical cantilever motion generated from biomolecular interactions." Proceedings of the National Academy of Sciences 98.4 (2001): 1560-1564.
 Gimzewski, J. K., et al. "Observation of a chemical reaction using a micromechanical sensor." Chemical Physics Letters 217.5-6 (1994): 589-594.
 Berger, R., et al. "Thermal analysis using a micromechanical calorimeter." Applied Physics Letters 69.1 (1996): 40-42.
 Mishra, Rohit, Wilfried Grange, and Martin Hegner. "Rapid and reliable calibration of laser beam deflection system for microcantilever-based sensor setups." Journal of Sensors 2012 (2011).
 Byun, Sangwon, et al. "Characterizing deformability and surface friction of cancer cells." Proceedings of the National Academy of Sciences 110.19 (2013): 7580-7585.
 Wirtz, Denis, Konstantinos Konstantopoulos, and Peter C. Searson. "The physics of cancer: the role of physical interactions and mechanical forces in metastasis." Nature Reviews Cancer 11.7 (2011): 512-522.
 Kalluri, Raghu, and Robert A. Weinberg. "The basics of epithelial-mesenchymal transition." The Journal of clinical investigation 119.6 (2009): 1420-1428.
 Drury, Jeanie L., and Micah Dembo. "Aspiration of human neutrophils: effects of shear thinning and cortical dissipation." Biophysical Journal 81.6 (2001): 3166-3177.
 Hochmuth, Robert M. "Micropipette aspiration of living cells." Journal of biomechanics 33.1 (2000): 15-22.
 Hansma, Helen G., and Jan H. Hoh. "Biomolecular imaging with the atomic force microscope." Annual review of biophysics and biomolecular structure 23.1 (1994): 115-140.
 Bausch, Andreas R., et al. "Local measurements of viscoelastic parameters of adherent cell surfaces by magnetic bead microrheometry." Biophysical journal 75.4 (1998): 2038-2049.
 Adamo, Andrea, et al. "Microfluidic-based assessment of cell deformability." Analytical chemistry 84.15 (2012): 6438.
 Chen, Jian, et al. "Classification of cell types using a microfluidic device for mechanical and electrical measurement on single cells." Lab on a Chip 11.18 (2011): 3174-3181.
 Marie, Rodolphe, et al. "Adsorption kinetics and mechanical properties of thiol-modified DNA-oligos on gold investigated by microcantilever sensors." Ultramicroscopy 91.1 (2002): 29-36.
 Cherian, Suman, et al. "Detection of heavy metal ions using protein-functionalized microcantilever sensors." Biosensors and Bioelectronics 19.5 (2003): 411-416.
 follo, Wan Y., et al. "Piezoelectric microcantilever sensors for biosensing." U.S. Patent No. 8,927,259. 6 Jan. 2015.