Search results for: pharmacometrics

Authors: Ragy Raafat Gaber Attaalla

Abstract:

Despite having the greatest rates of mortality and morbidity in the world, low- and middle-income (LMIC) nations trail high-income nations in terms of the number of clinical trials, the number of qualified researchers, and the amount of research information specific to their people. Health inequities and the use of precision medicine may be hampered by a lack of local genomic data, clinical pharmacology and pharmacometrics competence, and training opportunities. These issues can be solved by carrying out health care infrastructure development, which includes data gathering and well-designed clinical pharmacology training in LMICs. It will be advantageous if there is international cooperation focused at enhancing education and infrastructure and promoting locally motivated clinical trials and research. This paper outlines various instances where clinical pharmacology knowledge could be put to use, including pharmacogenomic opportunities that could lead to better clinical guideline recommendations. Examples of how clinical pharmacology training can be successfully implemented in LMICs are also provided, including clinical pharmacology and pharmacometrics training programmes in Africa and a Tanzanian researcher's personal experience while on a training sabbatical in the United States. These training initiatives will profit from advocacy for clinical pharmacologists' employment prospects and career development pathways, which are gradually becoming acknowledged and established in LMICs. The advancement of training and research infrastructure to increase clinical pharmacologists' knowledge in LMICs would be extremely beneficial because they have a significant role to play in global health.

Keywords: low- and middle-income, clinical pharmacology, pharmacometrics, career development pathways

Procedia PDF Downloads 91

Authors: Mamdouh Milad Adly Morkos

Abstract:

Despite having the greatest rates of mortality and morbidity in the world, low- and middle-income (LMIC) nations trail high-income nations in terms of the number of clinical trials, the number of qualified researchers, and the amount of research information specific to their people. Health inequities and the use of precision medicine may be hampered by a lack of local genomic data, clinical pharmacology and pharmacometrics competence, and training opportunities. These issues can be solved by carrying out health care infrastructure development, which includes data gathering and well-designed clinical pharmacology training in LMICs. It will be advantageous if there is international cooperation focused at enhancing education and infrastructure and promoting locally motivated clinical trials and research. This paper outlines various instances where clinical pharmacology knowledge could be put to use, including pharmacogenomic opportunities that could lead to better clinical guideline recommendations. Examples of how clinical pharmacology training can be successfully implemented in LMICs are also provided, including clinical pharmacology and pharmacometrics training programmes in Africa and a Tanzanian researcher's personal experience while on a training sabbatical in the United States. These training initiatives will profit from advocacy for clinical pharmacologists' employment prospects and career development pathways, which are gradually becoming acknowledged and established in LMICs. The advancement of training and research infrastructure to increase clinical pharmacologists' knowledge in LMICs would be extremely beneficial because they have a significant role to play in global health

Keywords: electromagnetic solar system, nano-material, nano pharmacology, pharmacovigilance, quantum theoryclinical simulation, education, pharmacology, simulation, virtual learning low- and middle-income, clinical pharmacology, pharmacometrics, career development pathways

Procedia PDF Downloads 102

Authors: Ramy Reda Morgan Kamel

Abstract:

generation-greater education gear are being unexpectedly included into health packages globally. these gadget provide an interactive platform for students and may be used to deliver topics in various modes which include video games and simulations. Simulations are of particular hobby to healthcare education, wherein they are hired to enhance clinical know-how and help to bridge the distance among precept and exercise. Simulations will regularly test talents for practical responsibilities, but restrained research examines the effects of simulation on student perceptions of their getting to know. The aim of this observe become to determine the effects of an interactive virtual patient simulation for pharmacology schooling and clinical workout on scholar know-how, skills and confidence. Ethics popularity of the examine end up received from Griffith college studies Ethics Committee (PHM/eleven/14/HREC). The simulation became intended to duplicate the pharmacy surroundings and affected man or woman interaction. The content material material come to be designed to beautify know-how of proton-pump inhibitor pharmacology, role in therapeutics and secure deliver to sufferers. The tool changed into deployed into a 3rd-year scientific pharmacology and therapeutics course. a number of core exercise regions were examined along with the competency domains of wondering, counselling, referral and product provision. Baseline measures of pupil self-stated knowledge, capabilities and self warranty were taken preceding to the simulation using a especially designed questionnaire. A greater substantial questionnaire became deployed following the virtual affected character simulation, which moreover blanketed measures of scholar engagement with the hobby. A quiz assessing scholar proper and conceptual understanding of proton-pump inhibitor pharmacology and associated counselling statistics changed into also included in both questionnaires.

Keywords: electromagnetic solar system, nano-material, nano pharmacology, pharmacovigilance, quantum theoryclinical simulation, education, pharmacology, simulation, clinical pharmacology, pharmacometrics, career development pathways

Procedia PDF Downloads 41

Authors: Ramy Reda Morgan Kamel

Abstract:

The idea of myocardial injury, despite the fact that first identified from animal studies, is now identified as a clinical phenomenon which can bring about microvascular harm, no-reflow phenomenon, myocardial lovely, myocardial hibernation and ischemic preconditioning. The final result of this occasion is left ventricular (LV) systolic disorder main to elevated morbidity and mortality. the standard scientific case of reperfusion damage takes place in acute myocardial infarction (MI) with ST segment elevation wherein an occlusion of a major epicardial coronary artery is accompanied through recanalization of the artery. this will arise either spontaneously or by thrombolysis and/or by means of number one percutaneous coronary intervention (PCI) with green platelet inhibition by using aspirin (acetylsalicylic acid), clopidogrel and glycoprotein IIb/IIIa inhibitors. In latest years, percutaneous coronary intervention (PCI) has emerge as a well-mounted approach for the remedy of coronary artery ailment. PCI improves symptoms in patients with coronary artery disorder and it's been increasing the safety of strategies. but, peri- and submit-procedural myocardial harm, including angiographical sluggish coronary float, microvascular embolization, and extended degrees of cardiac enzyme, along with creatine kinase and troponin-T and -I, has additionally been mentioned even in non-compulsory instances. moreover, myocardial reperfusion harm at the start of myocardial reperfusion, which reasons tissue damage and cardiac disorder, can also occur in cases of the acute coronary syndrome. due to the fact patients with myocardial damage is related to larger myocardial infarction and have a worse long-time period analysis than those without myocardial damage, it's far important to prevent myocardial harm throughout and/or after PCI in sufferers with coronary artery ailment. thus far, many studies have proven that adjunctive pharmacological treatment suppresses myocardial damage and increases coronary blood go with the flow throughout PCI strategies. in this evaluation, we spotlight the usefulness of pharmacological treatment in mixture with PCI in attenuating myocardial harm in sufferers with coronary artery disease.

Keywords: electromagnetic solar system, nano-material, nano pharmacology, pharmacovigilance, quantum theoryclinical simulation, education, pharmacology, simulation, clinical pharmacology, pharmacometrics, career development pathways

Procedia PDF Downloads 21