Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 2
Search results for: Shivkanya%20Fuloria
2 Discerning of Antimicrobial Potential of Phenylpropanoic Acid Derived Oxadiazoles
Authors: Neeraj Kumar Fuloria, Shivkanya Fuloria, Amit Singh
Abstract:
2-Phenyl propionic acid and oxadiazoles possess antimicrobial potential. 2-Phenyl propane hydrazide (1), on cyclization with aromatic acids offered 2-aryl-5-(1-phenylethyl)-1,3,4-oxadiazole derivatives (1A-E). The PPA derived oxadiazoles were characterized by elemental analysis and spectral studies. The compounds were screened for antimicrobial potential. The compound 1D bearing strong electron withdrawing group showed maximum antimicrobial potential. Other compounds also displayed antimicrobial potential to a certain extent. The SAR of newer oxadiazoles indicated that substitution of strong electronegative group in the PPA derived oxadiazoles enhanced their antimicrobial potential.Keywords: antimicrobial, imines, oxadiazoles, PPA
Procedia PDF Downloads 3331 Synthesis and Antimicrobial Activity of Tolyloxy Derived Oxadiazoles
Authors: Shivkanya Fuloria, Neeraj Kumar Fuloria, Sokinder Kumar
Abstract:
m-Cresol and oxadiazoles are the potent antimicrobial moieties. 2-(m-Tolyloxy)acetohydrazide (1) on cyclization with aromatic acids yielded 2-(aryl)-5-(m-tolyloxymethyl)-1,3,4-oxadiazole (1A-E). The structures of newer oxadiazoles were confirmed by elemental and spectral analysis. The newer compounds were evaluated for their antimicrobial potential. The compound 1E containing strong electron withdrawing group showed maximum antimicrobial potential. Other compounds also displayed antimicrobial potential to certain extent. The SAR of newer oxadiazoles indicated that substitution of strong electronegative group in the tolyloxy derived oxadiazoles enhanced their antimicrobial potential.Keywords: antibacterial, cresol, hydrazide, oxadiazoles
Procedia PDF Downloads 450