Search results for: IDSA

Authors: Ryan Kelvin Ford

Abstract:

For individuals and organizations, significant potential benefits were assured by sharing the data in a secure, trusted, and standardized environment. Technical trust and standards help each participant to use data space securely to share and access data. Sharing data in a safe environment helps acquire new business opportunities. Data sovereignty, interoperability, and trust were considered key factors to evaluate data spaces. Businesses and policymakers assure a fair data economy by integrating data space in organizations. A collaborative environment was needed to facilitate data sharing among organizations, satisfied with the implementation of different architectures using data spaces such as Eclipse Data Space Components (EDC), International Data Space Association (IDSA), Gaia-X, and Gaia-X Federation Services (GXFS). The last 15 years of application were reviewed and compared based on the architectures and implementations of different data spaces such as IDSA, EDC, Gaia-X and GXFS, EDC framework, IDSA, GXFS, data connector, data space architecture, characteristics of data space connectors, federated data spaces initiatives, data spaces overview, eclipse data space connector, designing data spaces, building data spaces based on technical overview, European future digital ecosystem based on Gaia-Vision and strategy of Gaia-Architecture. Empirical research based on an organized view was conducted. The current discussion elaborates on the systematic review of the impact of data space technology from various perspectives. The systematic review uses multiple databases such as IEEE Explore, Taylor & Francis, Science Direct, and Google Scholar to pursue publications on the impact of Data space from January 2019 to December 2024. The search results showcased a comparative review of 150 articles, out of which 20 were related to the IDSA, Gaia‑X, and EDC architecture and implementation.

Keywords: IDSA, Gaia-X, Gaia-X architecture, EDC, EDC architecture, GXFS architecture, IDSA, data space connector

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Authors: Mariem Meddeb Sidhom, Souhayel Hedfi, Rjaibia Houda, Mehdi Dridi, Mohamed Ali Yousfi, Sâadia Gargouri

Abstract:

Considering the important increase in costs of caspofungin treatments and ahead the evolution of its indication, pharmacy department was prompted to realize a review of the adequacy of prescriptions in the medical intensive care units (ICU). A retrospective observational study was conducted in Tunis military hospital concerning ICU prescriptions of caspofungin from 2008 until 2013. A pharmacist had returned to the patient’s medical records to collect data and to the microbiology department for parasitological results. The adequacy of prescriptions was evaluated by a pharmacist and an infectiologist parasitologist, referring to predefined scale of criteria resuming the indications of the marketing authorization (MA) and grade AI-AII of the guidelines of the Infectious Diseases Society of America (IDSA). Sixty two ICU patients have been treated with caspofungin during the period of study; however, 8 files were lost. Thus, 54 patients were included in the study having received 55 prescriptions of caspofungin. Males were a majority with 64.8% of the population. Mean age was 51 years. Caspofungin was indicated in accordance with the IDSA recommendations in 43.6% of the cases. The most case of non respect to the guidelines was the indication of caspofungin as empirical treatment in non neutropenic patients. Caspofungin was utilized as a first line treatment in 9 cases where it was possible to give fluconazole first, as germs were fluconazole- sensitive. Caspofungin was indicated in 2 patients with good renal function and in which nor amphotericin B, liposomal ampho B neither itraconazole had been previously used, as indicates the MA. The posology of caspofungin was respected in all prescriptions with a loading dose of 70 mg in the first day and a maintenance dose of 50 mg daily. Seven patients had received a daily dose of 70 mg, the recommended dose for people weighing more than 80 Kg. Caspofungin prescriptions are far to be adequately done. There is a clear need of optimization in indicating this molecule and that must be done in collaboration between the pharmacy department, the ICUs and parasitology department.

Keywords: caspofungin, prescription, intensive care units, marketing authorization, Tunisian hospital cohort

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