Development and Evaluation of Gastro Retentive Floating Tablets of Ayurvedic Vati Formulation
Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50 LV act as Matrixing agent, Carbopol as floating enhancer, microcrystalline cellulose as binder, Sodium bi carbonate as effervescent agent with other excipients. The simplex lattice design was used for selection of variables for tablets formulation. Formulation was optimized on the basis of floating time and in vitro drug release. The results showed that the floating lag time for optimized formulation was found to be 61 second with about 97.32 % of total drug release within 3 hours. The vitro release profiles of drug from the formulation could be best expressed zero order with highest linearity r2 = 0.9943. It was concluded that the gastroretentive drug delivery system can be developed for Marichyadi Vati containing Piperine to increase the residence time of the drug in the stomach and thereby increasing bioavailability.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1335952Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2292
 Anonymous, "The Ayurvedic Formulary of India”, Part-II, Govt. of India, Ministry of Health and Family Welfare, Dept. of Indian Systems of Medicine and Homeopathy, New Delhi, 189 .
 Goyal A., Kumar S., Nagpal M., Singh I., Arora S., " Potential of Novel Drug Delivery System for Herbal Drugs” Indian J. of Pharm. Edu. & Res. 2011, 45, 3.
 Atmakuri LR, Dathi S. "Current trends in herbal medicines” J Pharm Res 2010; 3(1):109-113.
 Brahmankar DM, Jaiswal SB. "Biopharmaceutics and st Pharmacokinetics A Treatise” 1 ed., New Delhi: Vallabh Prakashan; 1998 (reprint 2008):61, 359, 362.
 Lachman L, Lieberman HA, Kanig JL. "The Theory and Practice of Industrial Pharmacy” 3rd ed. Philadelphia: Lea & Febiger; 1996: 510-511.
 Agyilirah, G. A., Green, M., Ducret, R. "Evaluation of the gastric retention properties of a cross linked polymer coated tablets” Int. J. Pharm., Volume 75, Pages 241-247.
 Ali, A., Arora, S., Ahuja, A., Babbar, A.K., Sharma, R.K., Khar, R.K. "Formulation and development of floating capsules of celecoxib: in vitro and in vivo evaluation” AAPS Pharm SciTech., Volume 8, Issue 4, Pages E1-E7.
 Arora, S., Ali, A., Ahuja, A., Khar, R.K., Baboota, S. "Floating drug delivery systems: a review” AAPS PharmSciTech., Volume 5, Issue 6, Pages E372-E390.
 Arza, K.A., Gonugunta, S.C., Veerareddy, R.P. "Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets” AAPS Pharm SciTech., Volume 10, Issue 1, Pages 220-226.
 Chandel, A., Chauhan K., Parashar B., Kumar H., Arora S. "Floating drug delivery systems: A better approach” International Current Pharmaceutical Journal, Volume 1, Issue 5, Pages 110-118.
 Dave, Brijesh S., Amin, Avani F., Patel, Madhabhai M. "Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation” AAPS PharmSciTech., Volume 5, Issue 2, Pages 1-6.
 Davis, S. S., Stockwell, A. F., Taylor, M. J. "The effect of density on the gastric emptying of single and multiple unit dosage forms” Pharm. Res., Volume 3, Pages 208-213.
 Deshpande, A. A., Rhodes, C. T., Shah, N. H., Malick, A. W. "Controlled release drug delivery systems for prolonged gastric residence: An overview” Drug Dev. Ind. Pharm., Volume 22, Issue 6, Pages 531- 539.
 Deshpande, A. A., Shah, N. H., Rhodes, C. T., Malick, W. "Development of a novel controlled release system for gastric retention” Pharm. Res., Volume 14, Pages 815- 819.
 Goldsmith, J. A., Randall, N., Ross, S. D. "On methods of expressing dissolution rate data” J. Pharm. Pharmacol., Volume 30, Pages 347-349.
 Jaimini, M., Rana, A. C., Tanwar, Y. S. "Formulation and evaluation of famotidine floating tablets” Current Drug Delivery, Volume 4, Issue 1, Pages 51-55.