Towards Synthesis of Atropodiastereomeric Indolostilbenes Hybrids: A New Class of Oligostilbenoids

Authors: K. Ahmad, M. Suhaimi, Mohamad N. Azmi, K. Awang, Mohd A. Nafiah

Abstract:

The conceptually construction of axially chiral indolostilbenesi.eN-(2-{(E)-2-[2'-(1-Acetyl-1H-indol-2-yl)-3'chloro-4,4',6,6'-tetramethoxy[1,1'-biphenyl]-2yl]ethenyl}phenyl)acetamide and N-(2-{(E)-2-[2'-(1-Acetyl-1H-indol-2-yl)-3'-chloro-2,4',6,6'-tetramethoxy[1,1'-biphenyl]-4-yl]ethenyl}phenyl) acetamide are described in this paper. These structure, were obtained by the tactical combination of palladium-catalyzed coupling which produced 10-acetamido-3,5-dimethoxystilbene, follow by FeCl₃-induced oxidative cyclization/dimerisation. All structures were unambiguously confirmed by 1D (¹H, ¹³C) and 2D NMR experiment, (COSY, HMQC, HMBC) and mass spectrometry.

Keywords: Indolostilbene, FeCl3-oxidative cyclization, Oligostilbenooids, Oxidative cyclization/dimerization.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1089120

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