Commenced in January 2007
Paper Count: 30184
Fe3O4 and [email protected] Nanoparticles: Synthesis and Functionalisation for Biomolecular Attachment
Abstract:The use of magnetic and magnetic/gold core/shell nanoparticles in biotechnology or medicine has shown good promise due to their hybrid nature which possesses superior magnetic and optical properties. Some of these potential applications include hyperthermia treatment, bio-separations, diagnostics, drug delivery and toxin removal. Synthesis refinement to control geometric and magnetic/optical properties, and finding functional surfactants for biomolecular attachment, are requirements to meet application specifics. Various high-temperature preparative methods were used for the synthesis of iron oxide and gold-coated iron oxide nanoparticles. Different surface functionalities, such as 11-aminoundecanoic and 11-mercaptoundecanoic acid, were introduced on the surface of the particles to facilitate further attachment of biomolecular functionality and drug-like molecules. Nanoparticle thermal stability, composition, state of aggregation, size and morphology were investigated and the results from techniques such as Fourier Transform-Infra Red spectroscopy (FT-IR), Ultraviolet visible spectroscopy (UV-vis), Transmission Electron Microscopy (TEM) and thermal analysis are discussed.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1326716Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2586
 A. Cabot, V. F. Puntes, E. Shevchenko, Y. Yin, L. Balcells, M. A. Marcus, S. M. Hughes, and A. P. Alivisatos, "Vacancy coalescence during oxidation of iron nanoparticles", J. Am. Chem. Soc., vol. 129, no. 34, pp. 10358-10360, 2007.
 I. Koh, X. Wang, B. Varughese, L. Isaacs, S.H. Erhman, and D.S. English, "Magnetic iron oxide nanoparticles for biorecognition: evaluation of surface coverage and activity", J. Phys. Chem. B, vol. 110, no. 4, pp. 1553-1158, 2006.
 L.M. Bronstein, X. Huang, J. Retrum, A. Schmucker, M. Pink., B.D. Stein, and B. Dragnea, "Influence of iron oleate complex structure on iron oxide nanoparticles formation", Chem. Mater., vol. 19, no. 15, pp. 3624-3632, 2007.
 J-F. Lutz, S. Stiller, A. Hoth, L. Kaufer, U. Pison, and R. Cartier, "Onepot synthesis of PEGylated ultrasmall iron-oxide nanoparticles and their in vitro evaluation as magnetic resonance imaging contrast agents", Biomacromolecules, vol. 7, no. 11, pp. 3132-3138, 2006.
 S-J. Lee, J-R. Jeong, S-C. Shin, J-C. Kim, Y-H. Chang, K-H. Lee, and JD. Kim, "Magnetic enhancement of iron oxide nanoparticles encapsulated with poly(D,L-latide-co-glycolide)", Colloids and Surfaces A: Physicochem. Eng. Aspects, vol. 255, pp. 19-25, 2005.
 Z. Xu, Y. Hou, and S. Sun, "Magnetic core/shell Fe3O4/Au and Fe3O4/Au/Ag nanoparticles with tunable plasmodic properties", J. Am. Chem. Soc., vol. 129, no. 28, pp. 8698-8699, 2007.
 S-J. Cho, J-C. Idrobo, J. Olamit, K. Liu, N.D. Browning, and S.M. Kauzlarich, "Growth mechanisms and oxidation resistance of goldcoated iron nanoparticles", Chem. Mater. vol. 17, no. 12, pp. 3181-3186, 2005.
 P. Gangopadhyay, S. Gallet, E. Franz, A. Persoons, and T. Verbiest (). "Novel superparamagentic core(shell) nanoparticles for magnetic targeted drug delivery and hyperthermia treatment", IEEE Transactions on Magnetics vol. 41, no. 10, pp. 4194-4196, 2005.
 W. Wang, L. Luo, Q. Fan, M. Suzuki, I.S. Suzuki, M.H. Engelhard, Y. Lin, N. Kim, J.Q. Wang, and C-J Zhong, "Monodispersed core-shell [email protected] nanoparticles", J. Phys. Chem. B, vol. 46, no. 109, pp. 21593- 21601, 2005.
 S. Sun, and H. Zeng, "Size-controlled synthesis of magnetic nanoparticles", J. Am. Chem. Soc., vol. 124, no. 28, pp. 8204-8205, 2002.
 J-H. Huang, H.J. Parab, R-S. Liu, T-C. Lai, M. Hsiao, C-H. Chen, H-S. Sheu, J-M. Chen, D-P. Tsai, and Y-K. Hwu, "Investigation of the growth mechanism of iron oxide nanoparticles via a seed-mediated method and its cytotoxicity studies", J. Phys. Chem. C, vol. 112, no. 40, pp. 15684- 15690, 2008.
 S. Sun, H. Zeng, D.B. Robinson., S. Raoux, P.M. Rice, S.X. Wang, and G. Li, "Monodisperse MFeO (M = Fe, Co, Mn) nanoparticles", J. Am. Chem. Soc., vol. 126, no. 1, pp. 273-279, 2004.
 H.L. Liu, C.H. Sonn, J.H. Wu, K-M. Lee, and Y.K. Kim, "Synthesis of streptavidin-FITC-conjugated core-shell Fe3O4-Au nanocrystals and their application for the purification of CD4+ lymphocytes", Biomaterials, vol. 29, pp. 4003-4011, 2008.
 L. Wang, J. Luo, Q. Fan, M. Suzuki, I.S. Suzuki, M.H. Engelhard, Y. Lin, N. Kim, J.Q. Wang, C-J. Zhong, "Monodispersed core-shell [email protected] nanoparticles", J. Phys. Chem. B, vol. 109, no. 46, pp. 21593-21601, 2005.