Hendriƫtte van der Walt and Lesley Chown and Richard Harris and Ndabenhle Sosibo and Robert Tshikhudo
Fe3O4 and Fe3O4Au Nanoparticles Synthesis and Functionalisation for Biomolecular Attachment
560 - 564
2010
4
8
International Journal of Biotechnology and Bioengineering
https://publications.waset.org/pdf/7836
https://publications.waset.org/vol/44
World Academy of Science, Engineering and Technology
The use of magnetic and magneticgold coreshell
nanoparticles in biotechnology or medicine has shown good promise
due to their hybrid nature which possesses superior magnetic and
optical properties. Some of these potential applications include
hyperthermia treatment, bioseparations, diagnostics, drug delivery
and toxin removal. Synthesis refinement to control geometric and
magneticoptical properties, and finding functional surfactants for
biomolecular attachment, are requirements to meet application
specifics.
Various hightemperature preparative methods were used for the
synthesis of iron oxide and goldcoated iron oxide nanoparticles.
Different surface functionalities, such as 11aminoundecanoic and
11mercaptoundecanoic acid, were introduced on the surface of the
particles to facilitate further attachment of biomolecular functionality
and druglike molecules. Nanoparticle thermal stability, composition,
state of aggregation, size and morphology were investigated and the
results from techniques such as Fourier TransformInfra Red
spectroscopy (FTIR), Ultraviolet visible spectroscopy (UVvis),
Transmission Electron Microscopy (TEM) and thermal analysis are
discussed.
Open Science Index 44, 2010