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Mirror Neuron System Study on Elderly Using Dynamic Causal Modeling fMRI Analysis
Abstract:Dynamic Causal Modeling (DCM) functional Magnetic Resonance Imaging (fMRI) is a promising technique to study the connectivity among brain regions and effects of stimuli through modeling neuronal interactions from time-series neuroimaging. The aim of this study is to study characteristics of a mirror neuron system (MNS) in elderly group (age: 60-70 years old). Twenty volunteers were MRI scanned with visual stimuli to study a functional brain network. DCM was employed to determine the mechanism of mirror neuron effects. The results revealed major activated areas including precentral gyrus, inferior parietal lobule, inferior occipital gyrus, and supplementary motor area. When visual stimuli were presented, the feed-forward connectivity from visual area to conjunction area was increased and forwarded to motor area. Moreover, the connectivity from the conjunction areas to premotor area was also increased. Such findings can be useful for future diagnostic process for elderly with diseases such as Parkinson-s and Alzheimer-s.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1333748Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1409
 Friston, K.J., Harrison, L., and Penny, W., 2003, "Dynamic Causal Modelling", NeuroImage, Vol. 19, pp. 1273-1302.
 Friston, K.J., 2002, "What Can Neuroimaging Tell Us Abut Distributed Circuitry? Ann. Rev", Neuroscience, Vol. 25, pp. 221-250.
 Friston, K.J., B├╝chel, C., Fink, G.R., Morris, J., Rolls, E., and Dolan, R.J., 1997, "Psychophysiological and Modulatory Interactions in Neuroimaging", NeuroImage, Vol. 6, pp. 218-229.
 McIntosh, A.R., Grady, C., Ungerleider, L.G., Haxby, J.V., Rapoport, S.I., and Horwitz, B., 1994, "Network Analysis of Cortical Visual Pathways Mapped with Pet", neuroscience, Vol. 14, pp. 655-666.
 Fogassi, L., 2011, "The Mirror Neuron System: How Cognitive Functions Emerge from Motor Organization", Journal of Economic Behavior & Organization, Vol. 77, pp. 66-75.
 Fogassi, L., Ferrari, P.F., Gesierich, B., Rozzi, S., Chersi, F., and Rizzolatti, G., 2005, "Parietal Lobe: From Action Organization to Intention Understanding", Science, Vol. 308, pp. 662-667.
 Fogassi, L. and Luppino, G., 2005, "Motor Functions of the Parietal Lobe", Current Opinion in Neurobiology, Vol. 15, pp. 626-631.
 Galati, G., Committeri, G., Spitoni, G., Aprile, T., Russo, F.D., Pitzalis, S., and Pizzamiglio, L., 2008, "A Selective Representation of the Meaning of Actions in the Auditory Mirror System", NeuroImage, Vol. 40, pp. 1274-1286.
 Gallese, V., Fadiga, L., Fogassi, L., and Rizzolatti, G., 1996, "Action Recognition in the Premotor Cortex", Brain, Vol. 119, 2, pp. 593-609.
 Iacoboni, M., 2005, "Neural Mechanisms of Imitation", Current Opinion in Neurobiology, Vol. 15, 6, pp. 632-637.
 Iacoboni, M. and Dapretto, M., 2006, "The Mirror Neuron System and the Consequences of Its Dysfunction", Nature Reviews Neuroscience, Vol. 7, 12, pp. 942-951.
 Iacoboni, M., Woods, R.P., Brass, M., Bekkering, H., Mazziotta, J.C., and Rizzolatti, G., 1999, "Cortical Mechanisms of Human Imitation", Science, Vol. 286, pp. 2526-2528.
 Decety, J., Chaminade, T., Grezes, J., and Meltzoff, A.N., 2002, "A Pet Exploration of the Neural Mechanisms Involved in Reciprocal Imitation", NeuroImage, Vol. 15, pp. 265-272.
 Fabbri-Destro, M. and Rizzolatti, G., 2008, "Mirror Neurons and Mirror Systems in Monkeys and Humans", Physiology, Vol. 23, pp. 171-179.
 Grafton, S.T., Arbib, M.A., Fadiga, L., and Rizzolatti, G., 1996, "Localization of Grasp Representations in Humans by Positron Emission Tomography. 2. Observation Compared with Imagination", Exp. Brain Res, Vol. 112, pp. 103-111.
 Grezes, J., Armony, J.L., Rowe, J., and Passingham, R.E., 2003, "Activations Related to "Mirror" and "Canonical" Neurones in the Human Brain: An Fmri Study", NeuroImage, Vol. 18, pp. 928-937.
 Lamm, C., Fischer, M.H., and Decety, J., 2007, "Predicting the Actions of Others Taps into One's Own Somatosensory RepresentationsÔÇöa Functional Mri Study", Neuropsychologia, Vol. 44, pp. 2480-2491.
 Rizzolatti, G., Fogassi, L., and Gallese, V., 2001, "Neurophysiological Mechanisms Underlying the Understanding and Imitation of Action", Nat. Rev. Neurosci, Vol. 2, pp. 661-670.
 Marreiros, A.C., Kiebel, S.J., and Friston, K.J., 2008, "Dynamic Causal Modelling for Fmri: A Two-State Model", NeuroImage, Vol., pp. 269- 278.