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Non-Invasive Capillary Blood Flow Measurement: Laser Speckle and Laser Doppler
Abstract:Microcirculation is essential for the proper supply of oxygen and nutritive substances to the biological tissue and the removal of waste products of metabolism. The determination of blood flow in the capillaries is therefore of great interest to clinicians. A comparison has been carried out using the developed non-invasive, non-contact and whole field laser speckle contrast imaging (LSCI) based technique and as well as a commercially available laser Doppler blood flowmeter (LDF) to evaluate blood flow at the finger tip and elbow and is presented here. The LSCI technique gives more quantitative information on the velocity of blood when compared to the perfusion values obtained using the LDF. Measurement of blood flow in capillaries can be of great interest to clinicians in the diagnosis of vascular diseases of the upper extremities.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1333568Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2208
 Glenn Richards and J. D. Briers, "Capillary blood flow monitoring using laser speckle contrast analysis (LASCA): improving the dynamic range," 1997 in Proc. SPIE, vol. 2981, pp. 160-170.
 T. J. H. Essex and P. O. Byrne, "A laser Doppler scanner for imaging blood flow in skin," J. Biomed Eng., vol. 13, no. 3, 1991, pp.189-194.
 D. Ridgen and E. I. Gordon, "The granularity of scattered optical maser light," 1962 in Proc. IRE, pp. 2367-2368.
 G. J. Richards and J.D. Briers, "Laser speckle contrast analysis (LASCA): A technique for measuring capillary blood flow using the first order statistics of laser speckle patterns," 1997 in The Institution of Electrical Engineers, pp. 11/1-11/6.
 Yasuhiro Tamaki, Makoto Araie, Eizo Kawamoto, Shuichiro Eguchi and Hitoshi Fujii, "Noncontact two dimensional measurement of retinal microcirculation using laser speckle phenomenon," Investigative Ophthalmology and Visual Science, vol. 35, no. 11, Oct 1994, pp. 3825-3834.
 Haiying Cheng, Qingming Luo, Shaoqun Zeng, Shangbin Chen, Jian Cen and Hui Gong, "Modified laser speckle imaging method with improved spatial resolution," Journal of Biomedical Optics, vol. 8, no. 3, July 2003, pp. 559-564.
 Pengcheng Li, Songlin Ni, Li Zhang, Shaoqun Zeng and Qingming Luo, "Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging," Optics Letters, vol. 31, no. 12, June 2006, pp. 1824-1826.
 R.C. Bray, K. R. Forrester, J. Reed, C. Leonard and J. Tulip, "Endoscopic laser speckle imaging of tissue blood flow: Applications in the human knee," Journal of Orthopaedic Research, vol. 24, no. 8, Aug 2006, pp. 1650-1659.
 Seemantini K. Nadkarni et. al., "Characterization of atherosclerotic plaques by laser speckle imaging," Circulation, vol. 112, no.6, Aug 2005, pp. 885-892.
 Leonard W. Winchester and Nee Yin Chou, "Monitoring free tissue transfer using laser speckle imaging," 2006 in Proc. SPIE, vol. 6078, pp. 60780G-1-60780G-8.
 A. K. Jayanthy, N. Sujatha and M. Ramasubba Reddy, "Laser speckle contrast imaging for analysing static scatterer concentration in phantom body fluids," in 2009 Proc. ICOP Conf., pp. 26.
 A. K. Jayanthy, N. Sujatha and M. Ramasubba Reddy, "Noninvasive assessment of static scatterer concentration in phantom body fluids using laser speckle contrast analysis technique," Optics and Lasers in Engineering, vol. 49, no. 4, April 2011, pp. 553-556.
 B. Ruth, "Non-contact blood flow determination using a laser speckle method," Optics and Laser Technology, vol. 20, no. 6, December 1988, pp. 309-316.
 R. R. Anderson and J. A. Parrish, "The optics of human skin," J. Invest Dermatol, vol. 77, no. 1, 1981, pp. 13-19.
 J. T. Whitton and J. D. Everall, "The thickness of the epidermis," Br. J. Dermatol, vol. 89, 1973, pp. 467-476.
 P. Butti, M. Intaglietta, H. Reiman, Ch. Hollinger, A. Bollinger and M. Anliker, "Capillary red blood cell velocity measurements in human nailfold by videodensitometric method," Microvascular Research, vol. 10, 1975, pp. 220-227.
 B. Ruth, "Measuring the steady state value and the dynamics of the skin blood flow using the non contact laser speckle method," Med. Eng. Phys., vol. 16, 1994, pp. 105-111.
 J. W. Goodman, "Statistical properties of laser speckle patterns," in Laser Speckle and Related Phenomena, 2nd ed. Vol.9, J. C. Dainty, Ed. New York: Springer, 1975, pp. 9-75.
 Sean J. Kirkpatrick and Donald D. Duncan, "Optical assessment of tissue mechanics," in Handbook of Optical Biomedical Diagnostics, Valery V. Tuchin, Ed. Bellingham, Washington: SPIE, 2002, pp. 1047.
 J. W. Goodman, "Some fundamental properties of speckle," J. Opt. Soc. Am., vol. 66, no. 11, pp. 1145-1150, November 1976.
 J. David Briers and Sian Webster, "Laser speckle contrast analysis (LASCA): A nonscanning, full-field technique for monitoring capillary blood flow," J. Biomed. Opt., vol. 1, no. 2, 1996, pp. 174-179.
 J. D. Briers and S. Webster, "Quasi real time digital version of single exposure speckle photography for full field monitoring of velocity or flow fields," Optics Communications, vol. 116, 1995, pp. 36-42.
 R. Bonner and R. Nossal, "Model for laser Doppler measurements of blood flow in tissue," Appl. Optics, vol. 20, no. 12, June 1981, pp. 2097- 2107.
 Per Ask and P. Ake Oberg, "Blood flow measurements," in The Measurement Instrumentation and Sensors Handbook, John G. Webster, Ed. Springer Verlag, Heidelberg, Germany, 1999.
 J. David Briers, "Laser speckle and time varying speckle: a reconciliation,"J. Opt. Soc. Am. A, vol. 13, no. 2, Feb 1996, pp. 345- 350.