Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30569
Determination of Volatile Organic Compounds in Human Breath by Optical Fiber Sensing

Authors: C. I. L. Justino, L. I. B. Silva, K. Duarte, A. C. Freitas, T. A. P. Rocha-Santos, A. C. Duarte


This work proposes an optical fiber system (OF) for sensing various volatile organic compounds (VOCs) in human breath for the diagnosis of some metabolic disorders as a non-invasive methodology. The analyzed VOCs are alkanes (i.e., ethane, pentane, heptane, octane, and decane), and aromatic compounds (i.e., benzene, toluene, and styrene). The OF displays high analytical performance since it provides near real-time responses, rapid analysis, and low instrumentation costs, as well as it exhibits useful linear range and detection limits; the developed OF sensor is also comparable to a reference methodology (gas chromatography-mass spectrometry) for the eight tested VOCs.

Keywords: Volatile Organic Compounds, breath analysis, gas chromatography-mass spectrometry, optical fiber sensor

Digital Object Identifier (DOI):

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1887


[1] K.-H. Kim, S.A. Jahan, and E. Kabir, "A review of breath analysis for diagnosis of human health", Trends Anal. Chem., vol. 33, p. 1-8, 2012.
[2] P.J. Mazzone, "Analysis of volatile organic compounds in the exhaled breath for the diagnosis of lung cancer", J. Thorac. Oncol., vol. 3, p. 774-780, 2008.
[3] C. Wang, P. Sahay, "Breath analysis using laser spectroscopic techniques: breath biomarkers, spectral fingertips, and detection limits", Sensors, vol. 9, p. 8230-8262, 2009.
[4] F. Biasoli, C. Yeretzian, T.D. Märk, J. Dewulf, H.V. Langenhove, "Direct-injection mass spectrometry adds the time dimension to (B) VOC analysis", Trends Anal. Chem., vol. 30, p. 1003-1017, 2011.
[5] M. Biniecka, S. Caroli, "Analytical methods for the quantification of volatile aromatic compounds", Trends Anal. Chem., vol. 30, p. 1756- 1770, 2011.
[6] J. Luo, J. Luo, L. Wang, X. Shi, J. Yin, E. Crew, S. Lu, L.M. Lesperance, C.-J. Zhong, "Nanoparticle-structured thin film sensor arrays for breath sensing", Sens. Actuators B, vol. 161, p. 845-854, 2012.
[7] G. Magma, M. Santonico, A. Catini, R. Capuano, C. Di Natale, A. D-Amico, R. Paolesse, L. Tortora, "Detection of bretah alcohol concentrations using a gas sensor array", Lect. Notes Electr. Eng., vol. 109, p. 127-132.
[8] F.D.P. Ferreira, L.I.B. Silva, A.C. Freitas, T.A.P. Rocha-Santos, A.C. Duarte, "High performance liquid chromatography coupled to an optical fiber detector coated with laccase for screening catecholamines in plasma and urine", J. Chrom. A, vol. 1216, p. 7049-7054, 2009.
[9] L.I.B. Silva, F.D.P. Ferreira, A.C. Freitas, T.A.P. Rocha-Santos, A.C. Duarte, "Optical fiber biosensor coupled to chromatographic separation for screening of dopamine, norepinephrine and epinephrine in human urine and plasma", Talanta, vol. 80, p. 853-857, 2009.
[10] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, "Comparison of a gas chromatography-optical fibre (GC-OF) detector with a gas chromatography-flame ionization detector (GC-FID) for determination of alcoholic compounds in industrial atmospheres", Talanta, vol. 76, p. 395-399, 2008.
[11] L.I.B. Silva, T.A.P. Rocha-Santos, A.C. Duarte, "Remote optical fibre microsensor for monitoring BTEX in confined industrial atmospheres", Talanta, vol. 78, p. 548-552, 2009.
[12] C.I.L. Justino, T.A. Rocha-Santos, A.C. Duarte, "Review of analytical figures of merit of sensors and biosensors in clinical applications", TrAC Trends Anal. Chem., vol. 29, 1172-1183, 2010.
[13] D. Poli, P. Carbognani, M. Corradi, M. Goldoni, O. Acampa, B. Balbi, L. Bianchi, M. Rusca, A. Mutti, "Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study", Respir. Res., vol. 6:71, 2005.