Automated Optic Disc Detection in Retinal Images of Patients with Diabetic Retinopathy and Risk of Macular Edema
Authors: Arturo Aquino, Manuel Emilio Gegundez, Diego Marin
Abstract:
In this paper, a new automated methodology to detect the optic disc (OD) automatically in retinal images from patients with risk of being affected by Diabetic Retinopathy (DR) and Macular Edema (ME) is presented. The detection procedure comprises two independent methodologies. On one hand, a location methodology obtains a pixel that belongs to the OD using image contrast analysis and structure filtering techniques and, on the other hand, a boundary segmentation methodology estimates a circular approximation of the OD boundary by applying mathematical morphology, edge detection techniques and the Circular Hough Transform. The methodologies were tested on a set of 1200 images composed of 229 retinographies from patients affected by DR with risk of ME, 431 with DR and no risk of ME and 540 images of healthy retinas. The location methodology obtained 98.83% success rate, whereas the OD boundary segmentation methodology obtained good circular OD boundary approximation in 94.58% of cases. The average computational time measured over the total set was 1.67 seconds for OD location and 5.78 seconds for OD boundary segmentation.
Keywords: Diabetic retinopathy, macular edema, optic disc, automated detection, automated segmentation.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1085129
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2795References:
[1] H. R. Taylor and J. E. Keeffe, "World blindness: a 21st century perspective," Br. J. Ophthalmol., vol. 85, pp. 261-266, 2001.
[2] S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, "Global prevalence of diabetes: estimates for the year 2000 and projections for 2030," Diabetes Care, vol. 27, pp. 1047-1053, 2004.
[3] D. S. Fong, L. Aiello, T. W. Gardner, G. L. King, G. Blankenship, J. D. Cavallerano, F. L. Ferris, and R. Klein, "Diabetic retinopathy," Diabetes Care, vol. 26, pp. 226-229, 2003.
[4] A. Singalavanija, J. Supokavej, P. Bamroongsuk, C. Sinthanayothin, S. Phoojaruenchanachai, and V. Kongbunkiat, "Feasibility study on computer-aided screening for diabetic retinopathy," Jpn. J. Ophthalmol., vol. 50, pp. 361-366, 2006.
[5] N. Patton, T. M. Aslam, T. MacGillivray, I. J.Deary, B. Dhillon, R. H. Eikelboom, K. Yogesan, and I. J. Constable, "Retinal image analysis: concepts, applications and potential," Prog. Retin. Eye Res., vol. 25, pp. 99-127, 2006.
[6] C. Sinthanayothin, J. F. Boyce, H. L. Cook, and T. Williamson, "Automated localisation of the optic disc, fovea, and retinal blood vessels from digital colour fundus images," Br. J. Ophthalmol., vol. 83, pp. 902-910, 1999.
[7] H. Li and O. Chutatape, "Automatic location of optic disc in retinal images," in Proc. IEEE Int. Conf. on Image Proc., 2001, pp. 837-840.
[8] L. Gagnon, M. Lalonde, M. Beaulieu, and M. -C. Boucher, "Procedure to detect anatomical structures in optical fundus images," in Proc. Conf. Med. Imag. 2001: Image Process., San Diego, 2001, pp. 1218-1225.
[9] A. Osareh, M. Mirmehdi, B. Thomas, and R. Markham, "Automated identification of diabetic retinal exudates in digital colour images," Br. J. Ophthalmol., vol. 87, pp. 1220-1223, 2003.
[10] H. A. Quigley and A. T. Broman, "The number of people with glaucoma worldwide in 2010 and 2020," Br. J. Ophthalmol., vol. 90, pp. 262-267, 2006.
[11] H. Li and O. Chutatape, "A model-based approach for automated feature extraction in fundus images," in 9th IEEE Int. Conf. Computer Vision (ICCV-03), 2003, vol. 1, pp. 394-399.
[12] P. Massin, K. Angioi-Duprez, F. Bacin, B. Cathelineau, G. Cathelineau, G. Chaine, G. Coscas, J. Flament, J. Sahel, P. Turut, P. J. Guillausseau, and A. Gaudric, "Recommandations de l-ALFEDIAM pour le d'epistage et la surveillance de la r'etinopathie diab'etique," Diabetes Metab., vol. 22, pp. 203-209, 1996.
[13] P. Massin, K. Angioi-Duprez, F. Bacin, B. Cathelineau, G. Cathelineau, G. Chaine, G. Coscas, J. Flament, J. Sahel, P. Turut, P. J. Guillausseau, and A. Gaudric, "Recommandations de lALFEDIAM pour le d'epistage et la surveillance de la r'etinopathie diab'etique," J. Fr. Ophtalmol., vol. 20, pp. 302-310, 1997.
[14] Early Treatment Diabetic Retinopathy Study Research Group , "Grading diabetic retinopathy from stereoscopic color fundus photographsan extension of the Modified Airlie House classification: ETDRS report number 10," Ophthalmology, vol. 98, pp. 786-806, 1991.
[15] T. Walter and J. C. Klein, "Automatic analysis of color fundus photographs and its application to the diagnosis of diabetic retinopathy," in Handbook of Biomedical Image Analysis, vol. 2, pp. 315-368, 2005.
[16] R. C. Gonzalez and R. E. Woods, "Morphological Image Processing," in Digital Image Processing, 2nd ed. Prentice-Hall, pp. 577-581, 2002.
[17] R. C. Gonzalez and R. E. Woods, "Image Segmentation," in Digital Image Processing, 2nd ed. Prentice-Hall, pp. 577-581, 2002.
[18] N. Otsu, "A threshold selection method from gray-scale histogram," IEEE Trans. Syst. Man Cybern., vol. 8, pp. 62-66, 1978.
[19] R. C. Gonzalez and R. E. Woods, "Morphological Image Processing," in Digital Image Processing, 2nd ed. Prentice-Hall, pp. 525, 2002.
[20] P. V.C. Hough, Methods and Means for Recognizing Complex Patterns, US Patent 3 069 654, Dec. 1962.
[21] A. A.H.A.R. Youssif, A. Z. Ghalwash, and A. R Ghoneim, "Optic disc detection from normalized digital fundus images by means of a vessels- direction matched filter," IEEE Trans. Med. Imag, vol. 27, pp. 11-18, 2008.
[22] A. Osareh, M. Mirmehdi, B. Thomas, and R. Markham, "Comparison of colour spaces for optic disc localisation in retinal images," in 16th Int. Conf. Pattern Recognition, 2002, pp. 743-746.
[23] J. Lowell, A. Hunter, D. Steel, A. Basu, R. Ryder, E. Fletcher, and L. Kennedy, "Optic nerve head segmentation," IEEE Trans. Med. Imag., vol. 23, no. 2, pp. 256-264, 2004.
[24] C. Stellingwerf, P. Hardus, and J. Hooymans, "Assessing diabetic retinopathy using two-field digital photography and the influence of JPEG-compression," Doc. Ophthalmol., vol. 108, pp. 203-209, 2004.
[25] A. Basu, A. D. Kamal, W. Illahi, M. Khan, P. Stavrou, and R. E. J. Ryder, "Is digital image compression acceptable within diabetic retinopathy screening?," Diabet. Med., vol. 20, pp. 766-771, 2003.