Release Behavior of Biodegradable and Nonbiodegradable Polymeric Microparticles Loaded with Nimesulide

Authors: Shujaat A. Khan, Ghulam Murtaza

Abstract:

This presentation narrates the comparative analysis of the dissolution data nimesulide microparticles prepared with ethylcellulose, hydroxypropyl methylcellulose, chitosan and Poly(D,L-lactide-co-glycolide) as polymers. The analysis of release profiles showed that the variations noted in the release behavior of nimesulide from various microparticulate formulations are due to the nature of used polymer. In addition, maximum retardation in the nimesulide release was observed with HPMC (floating particles). Thus HPMC miacroparticles may be preferably employed for sustained release dosage form development.

Keywords: Nimesulide, microparticles, ethylcellulose, hydroxypropyl methylcellulose, chitosan and Poly(D, L-lactide-coglycolide).

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1085127

References:

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[5] S. A. Khan, M. Ahmad, M. N. Aamir, F. Rasool, G. Murtaza, "Design of Nimesulide-Chitosan Microparticles by pH Change Coacervation," Latin American Journal of Pharmacy, vol. 30, no. 7, pp. 1160-1266, June 2011.