Effect of Retinoic Acid on Fetus Reproductive Organ Mice (Mus musculus) Swiss Webster

Authors: Yulia Irnidayanti

Abstract:

Retinoic acid is like a steroid hormone that plays a role in embryo formation, proliferation of spermatogonia cells, ephitelial cells differentiation and organogenesis. Retinoic acid can influences seminiferous tubule formation during embryonic testis development and also play a role in the regulation of ovarian function and female reproductive tract by suppressing the hormones FSH receptor expression. The excessive use of retinoic acid caused abnormalities in the fetus. The result showed that there is the influence of retinoic acid on the developmet of mice fetal testes, for examples disruption of the formation of seminiferous tubules and tubules seemed to be hollow, spermatogonia cells are relatively few in number and caused Leydig cells count relatively more. While in the female fetus does not caused the formation of primordial follicles and disrupted the development of germinal ephitelial cells of fetal ovaries of female mice (mus musculus) Swiss Webster.

Keywords: Retinoic acid, Leydig cell, Spermatogonia cells, Semin- ferous tubules, Primordial follicles

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1079654

References:

[1] Munir, Warrety M. S. 1990. Perkembangan Embrio Ayam (Gallus gallus) yang diperlakukan dengan Vitamin A, MSG, dan Kombinasinya. Laporan penelitian.Universitas Andalas, Padang.
[2] Liss, Allan R. 1987. Recommendations for Vitamin A Use during Pregnancy. Teratology. 35:269-275.
[3] Yasuda, Yoshiko et al., 1986. Development Anomalies Induced by Alltrans Retinoic Acid in Fetal Mice Macroscopic Findings. Teratology.34:37-49.
[4] Livera, G., Fabre, V., Rouiller and R. Habert. 2001. Retinoid Receptors involved in The Effect of Retinoid Acid on Rat Testis Development. Biology of Reproduction. 64:1307-1314.
[5] Koshimizu, Uichi, Miho Watanabe, Norio Nakatsuji. 1995. Retinoic Acid is a Potent Growth Activator of Mouse Primordial Germ Cells In Vitro. Developmental Biology: 168:2:683-685
[6] Xing, Weirong and M. Ram Sairam. 2002. Retinoic Acid Mediates Transcriptional Repression of Ovine Follicle stimulating Hormone Receptor Gene via a Pleiotropic Nuclear Receptor Response Element. Biology of Reproduction: 67:204-211
[7] Rugh, R. 1971. A Guide To Vetebrate Development 6 th. Burgess Publishing Co. USA.
[8] Conn, H.J. dan M.A. Darrow. 1960. Staining Procedures. The William and Wilkins Co. Baltimore.P.146-147
[9] Sarmanu. 1988. "Histologis dan Ultras-truktur Testis Tikus Putih yang Diberi Pakan Mengandung Biji Lamtoro Gung". Laporan Penelitian. Surabaya: Universitas Airlangga.
[10] Granner and Daryl K. 2003. Kerja Hormon, dalam "Biokimia Harper", E/25. Penulis, Robert K. Murray et al., Alih Bahasa: Anna P. Bani dan Tiara M.N.S., Jakarta: Penerbit Buku Kedokteran - EGC.
[11] Purba, Dameriyani Nathalia. 2004. Pertumbuhan dan Perkembangan In Vitro Folikel Primordial pada Ovarium Mencit Dengan atau Tanpa Vitrifikasi (Skripsi). IPB. Bogor.