Effect of Copper Ions Doped-Hydroxyapatite 3D Fiber Scaffold
The mineral in human bone is not pure stoichiometric calcium phosphate (Ca/P) as it is partially substituted by in organic elements. In this study, the copper ions (Cu2+) substituted hydroxyapatite (CuHA) powder has been synthesized by the co-precipitation method. The CuHA powder has been used to fabricate CuHA fiber scaffolds by sol-gel process and the following sinter process. The resulted CuHA fibers have slightly different microstructure (i.e. porosity) compared to HA fiber scaffold, which is denser. The mechanical properties test was used to evaluate CuHA, and the results showed decreases in both compression strength and hardness tests. Moreover, the in vitro used endothelial cells to evaluate the angiogenesis of CuHA. The result illustrated that the viability of endothelial cell on CuHA fiber scaffold surfaces tends to antigenic behavior. The results obtained with CuHA scaffold give this material benefit in biological applications such as antimicrobial, antitumor, antigens, compacts, filling cavities of the tooth and for the deposition of metal implants anti-tumor, anti-cancer, bone filler, and scaffold.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.3566315Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 598
 Elrayah A, Zhi W, Feng S, Et Al. Preparation of Micro/Nano-Structure Copper-Substituted Hydroxyapatite Scaffolds with Improved Angiogenesis Capacity For Bone Regeneration (J). Materials (Basel), 2018, 11(9).
 S. Shanmugam And B. Gopal, "Copper Substituted Hydroxyapatite and Fluorapatite: Synthesis, Characterization and Antimicrobial Properties," Ceramics International, Vol. 40, Pp. 15655-15662, 2014.
 H. R. Bakhsheshi-Rad, E. Hamzah, M. Daroonparvar, M. A. M. Yajid, M. Kasiri-Asgarani, M. R. Abdul-Kadir, Et Al., "In-Vitro Degradation Behavior Of Mg Alloy Coated By Fluorine Doped Hydroxyapatite And Calcium Deficient Hydroxyapatite," Transactions Of Nonferrous Metals Society of China, Vol. 24, Pp. 2516-2528, 2014.
 A. Farzadi, F. Bakhshi, M. Solati-Hashjin, M. Asadi-Eydivand, And N. A. A. Osman, "Magnesium Incorporated Hydroxyapatite: Synthesis and Structural Properties Characterization," Ceramics International, Vol. 40, Pp. 6021-6029, 2014.
 S. C. Cox, P. Jamshidi, L. M. Grover, And K. K. Mallick, "Preparation and Characterisation of Nanophase Sr, Mg, and Zn Substituted Hydroxyapatite by Aqueous Precipitation," Mater Sci Eng C Mater Biol Appl, Vol. 35, Pp. 106-14, Feb 1 2014.
 J. Li, T. Xu, Q. Wang, J. Ren, K. Duan, Y. Mu, Et Al., "Integrating Surface Topography of Stripe Pattern on Pore Surface of 3-Dimensional Hydroxyapatiye Scaffolds," Materials Letters, Vol. 169, Pp. 148-152, 4/15/ 2016.
 M. A. Saghiri, A. Asatourian, J. Orangi, C. M. Sorenson, And N. Sheibani, "Functional Role of Inorganic Trace Elements in Angiogenesis-Part II: Cr, Si, Zn, Cu, And S," Crit Rev Oncol Hematol, Vol. 96, Pp. 143-55, Oct 2015.
 R. A. Luca L, Walpoth BH, Gurny R, Jordan O., "The Effects of Carrier Nature And Ph On Rhbmp-2-Induced Ectopic Bone Formation.," J Control Release Vol. 147, Pp. 38–44., 2010.
 L. Bi, S. Jung, D. Day, K. Neidig, V. Dusevich, D. Eick, Et Al., "Evaluation of Bone Regeneration, Angiogenesis, And Hydroxyapatite Conversion In Critical‐Sized Rat Calvarial Defects Implanted With Bioactive Glass Scaffolds," Journal Of Biomedical Materials Research Part A, Vol. 100, Pp. 3267-3275, 2012.
 Ye J, He J, Wang C, Et Al. Copper-Containing Mesoporous Bioactive Glass Coatings on Orbital Implants For Improving Drug Delivery Capacity And Antibacterial Activity(J). Biotechnology Letters, 2014, 36(5):961.
 M. Othmani, A. Aissa, H. Bachoua, and M. Debbabi, "Surface Modification of Calcium–Copper Hydroxyapatites Using Polyaspartic Acid," Applied Surface Science, Vol. 264, Pp. 886-891, 2013.
 S. Zhao, H. Wang, Y. Zhang, W. Huang, M. N. Rahaman, Z. Liu, Et Al., "Copper-Doped Borosilicate Bioactive Glass Scaffolds with Improved Angiogenic And Osteogenic Capacity for Repairing Osseous Defects," Acta Biomater, Vol. 14, Pp. 185-96, Mar 2015.
 C. Stahli, M. James-Bhasin, A. Hoppe, A. R. Boccaccini, And S. N. Nazhat, "Effect of Ion Release from Cu-Doped 45S5 Bioglass(R) On 3D Endothelial Cell Morphogenesis," Acta Biomater, Vol. 19, Pp. 15-22, Jun 2015.
 H. Wang, S. Zhao, W. Xiao, J. Xue, Y. Shen, J. Zhou, Et Al., "Influence of Cu Doping in Borosilicate Bioactive Glass and the Properties of Its Derived Scaffolds," Mater Sci Eng C Mater Biol Appl, Vol. 58, Pp. 194-203, Jan 1 2016.
 C. Wu, Y. Zhou, M. Xu, P. Han, L. Chen, J. Chang, Et Al., "Copper-Containing Mesoporous Bioactive Glass Scaffolds with Multifunctional Properties of Angiogenesis Capacity, Osteostimulation And Antibacterial Activity," Biomaterials, Vol. 34, Pp. 422-33, Jan 2013.
 F. Ren, Y. Leng, R. Xin, And X. Ge, "Synthesis, Characterization and Ab Initio Simulation of Magnesium-Substituted Hydroxyapatite," Acta Biomater, Vol. 6, Pp. 2787-96, Jul 2010.
 D. Xiao, T. Guo, F. Yang, G. Feng, F. Shi, J. Li, Et Al., "In Situ Formation of Nanostructured Calcium Phosphate Coatings on Porous Hydroxyapatite Scaffolds Using A Hydrothermal Method and the Effect on Mesenchymal Stem Cell Behavior," Ceramics International, Vol. 43, Pp. 1588-1596, 2017.
 G.-S. Lee, J.-H. Park, U. S. Shin, And H.-W. Kim, "Direct Deposited Porous Scaffolds of Calcium Phosphate Cement with Alginate for Drug Delivery and Bone Tissue Engineering," Acta Biomaterialia, Vol. 7, Pp. 3178-3186, 2011.
 T. N. Kim, Q. L. Feng, J. O. Kim, J. Wu, H. Wang, G. C. Chen, Et Al., "Antimicrobial Effects Of Metal Ions (Ag+, Cu2+, Zn2+) In Hydroxyapatite," Journal Of Materials Science: Materials In Medicine, Vol. 9, Pp. 129-34, 1998.
 Ž. Radovanović, B. Jokić, D. Veljović, S. Dimitrijević, V. Kojić, R. Petrović, Et Al., "Antimicrobial Activity And Biocompatibility Of Ag+- And Cu2+-Doped Biphasic Hydroxyapatite/Α-Tricalcium Phosphate Obtained From Hydrothermally Synthesized Ag+- And Cu2+-Doped Hydroxyapatite," Applied Surface Science, Vol. 307, Pp. 513-519, 2014.
 K. Sekine, M. Sakama, And K. Hamada, "Evaluation of Strontium Introduced Apatite Cement as the Injectable Bone Substitute Developments," In Engineering in Medicine And Biology Society, 2013, P. 858.