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Influence of Moringa Leaves Extract on the Response of Hb Molecule to Dose Rates’ Changes: II. Relaxation Time and Its Thermodynamic Driven State Functions

Authors: Mohamed M. M. Elnasharty, Azhar M. Elwan


Irradiation deposits energy through ionisation changing the bio-system’s net dipole, allowing the use of dielectric parameters and thermodynamic state functions related to these parameters as biophysical detectors to electrical inhomogeneity within the biosystem. This part is concerned with the effect of Moringa leaves extract, natural supplement, on the response of the biosystem to two different dose rates of irradiation. Having Hb molecule as a representative to the biosystem to be least invasive to the biosystem, dielectric measurements were used to extract the relaxation time of certain process found in the Hb spectrum within the indicated frequency window and the interrelated thermodynamic state functions were calculated from the deduced relaxation time. The results showed that relaxation time was decreased for both dose rates indicating a strong influence of Moringa on the response of biosystem and consequently Hb molecule. This influence was presented in the relaxation time and other parameters as well.

Keywords: Activation Energy, relaxation time, DC conductivity, dielectric relaxation, enthalpy change, Moringa leaves extract

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[1] Abu Taher M., Abu Bin Nyeem M., Ahammed Md. M., Hossain Md. M. and Islam M.N. (2017). Review: Moringa oleifera (Shajna): the wonderful indigenous medicinal plant. Asian J. Med. Biol. Res. 2017, 3 (1), 20-30.
[2] Moyo B., Masika P. J., Hugo A. and Muchenje V. (2011). Nutritional characterization of Moringa (Moringa oleifera Lam) leaves. Afr. J Biotechnol. 10(60):12925-12933.
[3] Nalamwar R. R., Raut S. D., Khan N. D., Khan Z. H. and Mular S.M. (2017). Nutritional assessment of Moringa oleifera leaves. IJAR 3(3): 411–413.
[4] Chelliah, R., Ramakrishnan, S. and Antony, U. (2017). Nutritional quality of Moringa oleifera for its bioactivity and antibacterial properties. IFRJ 24(2): 825-833.
[5] Omodanisi, E. I, Yapo G., Aboua Y. G. and Oguntibeju O. O. (2017). Hepatoprotective, Antihyperlipidemic, and Anti-inflammatory Activity of Moringa oleifera in Diabetic-induced Damage in Male Wistar Rats. Pharmacognosy Res. 2017 Apr-Jun; 9(2):182-187.
[6] Welch R. H. and Tietje A. H. (2017). Investigation of Moringa oleifera leaf extract and its cancer-selective antiproliferative properties. Journal of the South Carolina Academy of Science 15: (2) Article 4, 13 pages.
[7] Xianjuan Kou, Biao Li, Julia B. Olayanju, Justin M. Drake and Ning Chen (2018). I Nutraceutical or Pharmacological Potential of Moringa oleifera Lam. Nutrients; 10(343); 12 pages, doi:10.3390 /nu10030343.
[8] Rao A.V., Devi P.U. and Kamath R. (2001). In vivo radioprotective effect of Moringa oleifera leaves. Indian J. Experl Biol.; 39: 858-863.
[9] Arora R., Gupta D., Chawla R., Sagar R., Sharma A., Kumar R., Prasad J., Singh S., Samanta N. and Sharma R.K. (2005). Radioprotection by Plant Products: Present Status and Future Prospects. Phytother. Res. 19: 1–22.
[10] Bhandari P. R. (2013). A review of radioprotective plants. IJGP 7(2): 90–101.
[11] Elwan A. M., Salama A. A., Said A. M., Ghoneim A. M., Elssaied A. A., Ibrahim F. A., and Elnasharty M. M. M. (2018). Biophysical and biochemical roles of Moringa oleifera leaves as radioprotector. Progress in Biophysics and Molecular Biology 140, 142-149.
[12] Elnasharty M. M. M., Ghoneim A. M., Elwan A. M. (2018) Dielectric and thermodynamic study of Hb exploring Moringa Oleifera leaves extract potential against radiation damage. Progress in Biophysics and Molecular Biology 140, 150-154.
[13] Elnasharty, M. M. M., Hany A. Shousha, and Elwan A. M. (2018). Permittivity, entropy, free and internal energies as tools for detecting radiation dose rates’ changes in Hb, Progress in Biophysics and Molecular Biology. Progress in Biophysics and Molecular Biology 140, 74-78.
[14] Elwan A. M., Salama A. A., Sayed A. M., Ghoneim A. M., Assaied A. A., Ibrahim F. A., Shousha H. A. and Elnasharty M. M. M. (2018). Response of rats to dose rates of ionizing radiation evaluated by dielectric properties of bone marrow. Progress in Biophysics and Molecular Biology 140, 124-132.
[15] Płowas I., Swiergiel J., and Jadzyn J. (2014). Electrical Conductivity in Dimethyl Sulfoxide + Potassium Iodide Solutions at Different Concentrations and Temperatures, J. Chem. Eng. Data, 59: 2360-2366.
[16] Shamsudin I. J., Ahmad A., Hassan N. H. and Kaddami H. (2015). Bifunctional ionic liquid in conductive biopolymer based on chitosan for electrochemical devices application. Solid State Ionics; 278: 11–19.
[17] Idris N. H., Majid S. R., Khiar A. S. A., Hassan M. F. and Arof A. K. (2005). Conductivity Studies on Chitosan/PEO Blends with LiTFSI Salt. Ionics; 11: 375-377.
[18] Donald T. Haynie (2008). “Biological Thermodynamics”, Ch. 2. “The first law of thermodynamics” pp 25-53., 2nd. Ed. Cambridge Uni. Press.
[19] Grant E. H., South G. P., Takashima S. and Ichimura H. (1971). “Dielectric dispersion in aqueous solutions of oxyhaemoglobin and carboxyhaemoglobin”, Biochem. J.; 122: 691-699.
[20] Ugwu O. P. C., Nwodo O. F. C., Joshua P. E., Abubakar B., Ossai E. C. and Christian O. (2013). Phytochemical and acute toxicity studies of Moinga oleifera ethanol leaf extract. Int. J. Life. Sc. Bt& Pharm. Res; 2(2): 65-71.
[21] Busani Moyo, Patrick J. Masika, Arnold Hugo and Voster Muchenje (2011). Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves, African Journal of Biotechnology; 10(60): 12925-12933.
[22] Teklit Gebregiorgis Amabye, Afework Mulugeta Bezabh and Kindeya Gebrehiwot (2015). Chemical Compositions and Nutritional Value of Moringa Oleifera Available in the Market of Mekelle. Journal of Food and Nutrition Sciences; 3(5): 187-190.
[23] Lakshmipriya Gopalakrishnan, Kruthi Doriya, Devarai Santhosh Kumar (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. Food Science and Human Wellness; 5: 49–56.