Evaluation of TRIS-DMA-NVP Hydrogels for Making Silicone-Based Contact Lenses
In this study, contact lenses were prepared through the polymerization of tris-(trimethyl-silyl-propyl-methacrylate) (TRIS), N,N-dimethylacrylamide (DMA), N-vinylpyrrolidone (NVP), and cross-linked with ethylene glycol dimethylacrylate (EGDMA). The equilibrium water content (EWC), oxygen permeability (Dk), light transmittance, and in vitro cytotoxicity of TRIS-DMA-NVP with various ratios were measured. The results showed that the EWC increased while the Dk decreased with the increase of NVP content. For the sample with 25 wt% NVP, the EWC attained 53% whereas the Dk decreased to 46 barrers. All these lenses exhibited light transmittance over than 95%. In addition, all these lenses exhibited no inhibition to the growth of L292 fibroblasts. Thus, this study showed that TRIS-DMA-NVP can be applicable for making contact lens.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1316796Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 575
 S. L. Willis, J. L. Court, R. P. Redman, J.-H. Wang, S. W. Leppard, et al., "A novel phosphorylcholine-coated contact lens for extended wear use," Biomaterials, vol. 22, pp. 3261-3272, 2001.
 Y. C. Lai, "Effect of crosslinkers on photocopolymerization of N‐vinylpyrrolidone and methacrylates to give hydrogels," J. Appl. Polym. Sci., vol. 66, pp. 1475-1484, 1997.
 Q. Garrett, B. Laycock, and R. W. Garrett, "Hydrogel lens monomer constituents modulate protein sorption," Invest. Ophthalmol. Vis. Sci., vol. 41, pp. 1687-1695, 2000.
 V. Compan, A. Andrio, A. Lopez-Alemany, E. Riande, and M. Refojo, "Oxygen permeability of hydrogel contact lenses with organosilicon moieties," Biomaterials, vol. 23, pp. 2767-2772, 2002.
 J. T. Jacob, "Biocompatibility in the development of silicone-hydrogel lenses," Eye Contact Lens, vol. 39, pp. 13-19, 2013.
 Y. C. Lai, "Novel polyurethane–silicone hydrogels," J. Appl. Polym. Sci., vol. 56, pp. 301-310, 1995.
 N. Chekina, V. Pavlyuchenko, V. Danilichev, N. Ushakov, S. Novikov, et al., "A new polymeric silicone hydrogel for medical applications: synthesis and properties," Polym. Advan. Technol., vol. 17, pp. 872-877, 2006.
 Y. C. Lai, "Novel silicone hydrogel based on PDMS and PEGMA for contact lens application," J. Appl. Polym. Sci., vol. 56, pp. 301-310, 1995.
 J. J. Wang and F. Liu, "Simultaneous interpenetrating network silicone hydrogels prepared by free radical/cationic hybrid polymerization," J. Appl. Polym. Sci., vol. 127, pp. 2235-2242, 2013.
 M. P. Mullarney, T. A. Seery, and R. Weiss, "Drug diffusion in hydrophobically modified N, N-dimethylacrylamide hydrogels," Polymer, vol. 47, pp. 3845-3855, 2006.
 Z. Zhao, H. Xie, S. An, and Y. Jiang, "The relationship between oxygen permeability and phase separation morphology of the multicomponent silicone hydrogels," J. Phys. Chem. B., vol. 118, pp. 14640-14647, 2014.
 C.-H. Lin, H.-L. Cho, Y.-H. Yeh, and M.-C. Yang, "Improvement of the surface wettability of silicone hydrogel contact lenses via layer-by-layer self-assembly technique," Colloids Surf., B, vol. 136, pp. 735-743, 2015.
 D. T. R. Austin and B. P. Hills, "Two-dimensional NMR relaxation study of the pore structure in silicone hydrogel contact lenses," Appl. Magn. Reson., vol. 35, pp. 581-591, 2009.
 J. J. Nichols, G. L. Mitchell, and G. W. Good, "The reliability and validity of hand-held refractometry water content measures of hydrogel lenses," Optom. Vis. Sci., vol. 80, pp. 447-453, 2003.
 I. Tranoudis and N. Efron, "Water properties of soft contact lens materials," Contact Len Anterio, vol. 27, pp. 193-208, 2004.
 C. Maldonado-Codina and N. Efron, "Hydrogel lenses-material and manufacture: a review," Optometry in Practice, vol. 4, pp. 101-115, 2003.
 A. M. Parambil, Y. M. Puttaiahgowda, and P. Shankarappa, "Copolymerization of N-Vinyl pyrrolidone with methyl methacrylate by Ti (III)-DMG redox initiator," Turk. J. Chem., vol. 36, pp. 397-409, 2012.
 Z.-B. Zhao, S.-S. An, H.-J. Xie, X.-L. Han, F.-H. Wang, et al., "The Relationship between the Hydrophilicity and Surface Chemical Composition Microphase Separation Structure of Multicomponent Silicone Hydrogels," J. Phys. Chem. B., vol. 119, pp. 9780-9786, 2015.
 J. Wang and X. Li, "Preparation and characterization of interpenetrating polymer network silicone hydrogels with high oxygen permeability," J. Appl. Polym. Sci., vol. 116, pp. 2749-2757, 2010.
 K. French, "Contact lens material properties. Part 3–Oxygen performance," Optician, vol. 230, pp. 16-21, 2005.
 J. Pozuelo, V. Compañ, J. M. González-Méijome, M. González, and S. Mollá, "Oxygen and ionic transport in hydrogel and silicone-hydrogel contact lens materials: an experimental and theoretical study," J. Membr. Sci., vol. 452, pp. 62-72, 2014.
 J.-j. Wang and X.-s. Li, "Improved oxygen permeability and mechanical strength of silicone hydrogels with interpenetrating network structure," Chin. J. Polym. Sci., vol. 28, pp. 849-857, 2010
 M. Korogiannaki, G. Guidi, L. Jones, and H. Sheardown, "Timolol maleate release from hyaluronic acid-containing model silicone hydrogel contact lens materials," J. Biomater. Appl., vol. 30, pp. 361-376, 2015.
 Luensmann, D. and L. Jones, Protein deposition on contact lenses: the past, the present, and the future. Contact Lens and Anterior Eye, 2012. 35(2): p. 53-64.