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Mass Transfer of Paracetamol from the Crosslinked Carrageenan-Polyvinyl Alcohol Film

Authors: Sperisa Distantina, Rieke Ulfha Noviyanti, Sri Sutriyani, Fadilah Fadilah, Mujtahid Kaavessina

Abstract:

In this research, carrageenan extracted from seaweed Eucheuma cottonii was mixed with polyvinyl alcohol (PVA) and then crosslinked using glutaraldehyde (GA). The obtained hydrogel films were applied to control the drug release rate of paracetamol. The aim of this research was to develop a mathematical model that can be used to describe the mass transfer rate of paracetamol from the hydrogel film into buffer solution. The effect of weight ratio carrageenan-PVA (5: 0, 1: 0.5, 1: 1, 1: 2, 0: 5) on the parameters of the mathematical model was investigated also. Based on the experimental data, the proposed mathematical model could describe the mass transfer rate of paracetamol. The weight ratio of carrageenan-PVA greatly affected the amount of paracetamol absorbed in the hydrogel film and the mass transfer rate of paracetamol.

Keywords: Carrageenan-PVA, crosslinking, hydrogel, glutaraldehyde, paracetamol, mass transfer.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1132118

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References:


[1] Shi, A., Li, D., Liu, H., Adhikari, B., and Wang , Q., 2016, “ Effect of drying and loading methods on the release behavior of ciprofloxacin from starch nanoparticles”, International Journal of Biological Macromolecules, 87, 55-61.
[2] Agarwal, T., Narayana, S. N. G. H., Pal, K., Pramanik, K., Giri, S., and Banerjee, I., 2015, “Calcium alginate-carboxymethyl cellulose beads for colon-targeted drug delivery”, International Journal of Biological Macromolecules, 75, 409-417.
[3] Lohani, A., Singh, G., Bhattacharya, S. S., Hegde, R. R., and Verma, A., 2016, “Tailored-interpenetrating polymer network beads of k-carrageenan and sodium carboxymethyl cellulose for controlled drug delivery”, Journal of Drug Delivery Science and Technology, 31, 53-64.
[4] Jiang, S., Liu, S, and Feng, W., 2011, “PVA hydrogel properties for biomedical application”, Journal of the Mechanical Behavior of Biomedical Material, 4, 1228-1233.
[5] Fouda, M. M. G., El-Aassar, M. R., El Fawal, G. F., Hafez, E. E., Masry, S. H., Abdel-Megeed, A., 2015, Κ-carragenan/polyvinyil pyrollidone/polyethylene glycol/silver nanoparticles film for biomedical application. International Journal of Biological Macromolecules, 74, 179-184.
[6] Van de Velde, F., Knutsen, S. H., Usov, A. I., Rollema, H. S., and Cerezo, A. S., 2002. 1H and 13C high resolution nmr spectoscopy of carrageenans: aplication in research and industry. Trend in Food Science and Technology. 13, 73-92.
[7] V. L. Campo, F. F. Kawano, D. B. Silva Junior, and I. Carvalho, “Carrageenans: biological properties, chemical modifications and structural analysis”, Carbohyd. Polym., 2009, 77, pp. 167-180.
[8] Hezaveh, H. and Muhamad, I. I., 2012. Controlled drug release via minimization of burst release in ph-response kappa-karagenan/polyvinyl alcohol hydrogel”, Chemical Engineering Research and Design, http://dx.doi.orh/10.1016/j.cherd.2012.08.014.
[9] Fernandez-Colino, A., Bermudez, J. M., Arias, F. J., Quinteros, D., and Gonzo, E., 2016, Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel, Materials Science and Engineering C, 61, 286-292.
[10] Treybal, R. E., 1980, Mass Transfer Operations,3th ed. McGraw-Hill Book Company, Singapore.
[11] Geankoplis, C. J. 1973. Transport Processes and Unit Operations. 3th ed., McGraw-Hill Book Co., Singapore.
[12] Mansur, H. S., Carolina, M. S, et.al., 2008. FTIR Spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde. Elsevier. pp 539-548.