Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30121
In vivo Therapeutic Potential of Biologically Synthesized Silver Nanoparticles

Authors: Kalakotla Shanker, G. Krishna Mohan

Abstract:

Nowadays, nanoparticles are being used in pharmacological studies for their exclusive properties such as small size, more surface area, biocompatibility and enhanced solubility. In view of this, the present study aimed to evaluate the antihyperglycemic potential of biologically synthesized silver nanoparticles (BSSNPs) and Gymnema sylvestre (GS) extract. The SEM and SEM analysis divulges that the BSSNPs were spherical in shape. EDAX spectrum exhibits peaks for the presence of silver, carbon, and oxygen atoms in the range of 1.0-3.1 keV. FT-IR reveals the binding properties of active bio-constituents responsible for capping and stabilizing BSSNPs. The results showed increased blood glucose, huge loss in body weight and downturn in plasma insulin. The GS extract (200 mg/kg, 400 mg/kg), BSSNPs (100 mg/kg, 200 mg/kg) and metformin 50 mg/kg were administered to the diabetic rats. BSSNPs at a dose level of 200 mg/kg (b.wt.p.o.) showed significant inhibition of (p<0.001) blood glucose levels as compared with GS extract treated group. The results obtained from study indicate that the BSSNP shows potent anti-diabetic activity.

Keywords: BSSNP, G.sylvetre, wistar rats, antihyperglycemic activity.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1129557

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 649

References:


[1] Sicree R, Shaw J, Prevalence and projections. In: Gan D (ed.) DiabetesAtlas International Diabetes Federation, 3rd edn. International Diabetes Federation, Brussels, Belgium, 2006; 16-104.
[2] Mittal AK, Chisti Y, Banerjee UC. Synthesis of metallic nanoparticles using plants. Biotechnology Adv 2013; 31: 346-56.
[3] K. Rajaram, Suresh kumar, Green synthesis of silver nanoparticles using Tephrosia tinctoria and its anti-diabetic activity, Materials Letters,138;2015: 251-254
[4] Babu G, Arulvasu C, Biosynthesis andcharacterization of silver nanoparticles from Datura inoxia and its apoptotic effect on human breast cancer cell line MCF7. Materials Letters 2014; 122:98-102
[5] Omid Veiseh, Benjamin G. Managing diabetes with nanomedicine: challenges and opportunities, Nat Rev Drug Discov. 2015, 14(1):45-57.
[6] Pragya Tiwari, B. Mishra, Phytochemical and Pharmacological Properties of Gymnema sylvestre: An Important Medicinal Plant Bio Med Research International, 2014, page: 1-18.
[7] Vogel, H.G, W.H, 2002. Chapter K: Anti-diabetic activity, Drug discovery and evaluation, pharmacological assays, 2ndedition. Springer publication, pp 535-538.
[8] Bonner Weir S. Morphological evidence of pancreatic polarity of beta cells within islets of langerhans. Diabetes journal, 1988Íž37: page: 616-21.
[9] K. Rajaram, D.C. Aiswarya, Green synthesis of silver nanoparticle using Tephrosia tinctoria and its antidiabetic activity, Materials Letters 2015, 138;251-254.
[10] Shanmugasundaram ER, Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin dependent diabetes mellitus. J. Ethno pharmacology. (1990) 30: page: 281-294.
[11] K. Rajaram, D.C. Aiswarya, P. Sureshkumar, Green synthesis of silver nanoparticle using Tephrosia tinctoria and its antidiabetic activity, Materials Letters 2015, 138 : page: 251-254.