Study Regarding Effect of Isolation on Social Behaviour in Mice
Authors: Ritu Shitak
Humans are social mammals, of the primate order. Our biology, our behaviour and our pathologies are unique to us. In our desire to understand, reduce solitary confinement one source of information is the many reports of social isolation of other social mammals, especially primates. A behavioural study was conducted in the department of pharmacology at Indira Gandhi Medical College, Shimla in Himachalpradesh province in India using white albino mice. Different behavioural parameters were observed by using open field, tail suspension, tests for aggressive behaviour and social interactions and the effect of isolation was studied. The results were evaluated and the standard statistics were applied. The said study was done to establish facts that isolation itself impairs social behaviour and can lead to alcohol dependence as well as related drug dependence.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1338192Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1804
 Deacon RM. Housing, husbandry and handling of rodents for behavioural experiments .Nat Protoc.2006; 1:936-946.
 Berry, A., Bellisario, V.,Capoccia, S.,Tirassa, P.,Calza,A., Alleva, E.,&Cirulli, F.(2012)Social deprivation stress is a triggering factor for the emergence of anxiety and depression like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice. Psychoneuroendocrinolgy, 37,762-777.
 Chuljungkwak. Social isolation selectively increases anxiety in mice without affecting depression like behaviour. Korean J PhysioPharmacol. 2009 October; 13(5):357-360.
 Miczek KA, Maxson SC, Fish EW, Faccidomo S (2001). Aggressive behavioural phenotypes in mice. Behav Brain Res 125: 167-181.
 Winslow JT (2003) Mouse social recognition and preference, In; Current protocols in neuroscience, 8.16.1-16.3. New York: Wiley.
 Brown, K.J.,& Gruenberg , N.E.(1995).Effects of housing on male and female rats: Crowding stressed males but calms females. Physiology &Behaviour, 58(6), 1085-1089.
 Bert Siegfried, Enrico Alberto Oliverio, Stefano Puglisialllegra. Effects of isolation on activity, reactivity, excitability alpha aggressive behaviour in the two inbred stains of mice, Behavioural brain research. Vol-2, issue-2, March 1981, pages 211-218.
 N. Wongwitdecha, C.A. Marsden, Social isolation increases aggressive behaviour and alters the effects of diazepam in the rat social interaction test, behavioural brain research. Vol 75, issues 1-2, Feb. 1996, pages 27- 32.
 Benoit –Petit- Demoutier- Franck Chenu, Michel Bourin, Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology (2005) 177: 245-255, DOI 10, 1007/ SO213-004- 2048-7.
 Taylor, Shelley E, Klein, Laura Cousino; Lewis Brain P , Grvenewald, Tara L; Gurung Regan A, R updegratt, John A. Psychologiacal Review Vol 107(3), Jul 2000. Pages 411-429.
 Prut L, Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety like behaviours: a review.Eur J Pharmacol. 2003:463:-33.
 Chourabaji S, Zacher C, Sanchis – Segura C, Spanagel R, Gass P. Social and structural housing conditions influence the development of a depressive like phenotype in the learned helplessness paradigm in male mice. Behav Brain Res. 2005; 100-106.
 Cristiane Felisbino Silvab, Filipe SilveiraDuarteb, Thereza Christina Monteiro De Limab, CileneLino de Oliveiraa, Effects of social isolation and enriched environment on behavior of adult Swiss mice do not require hippocampal neurogenesis. Behavioural Brain Research Volume 225, Issue 1, 20 November 2011, Pages 85–90
 Lister RG, Hilakivi LA,The effects of novelty, isolation, light and ethanol on the social behavior of mice. Psychopharmacology (Berl). 1988;96(2).