Search results for: Areeg Faggad

Authors: Mengistu G. Woldu, Hani Y. Zaki, Areeg Faggad, Badreldin E. Abdalla

Abstract:

Background: Type 2 diabetes mellitus (T2DM) is a complex, degenerative, and multi-factorial disease, which is culpable for huge mortality and morbidity worldwide. Even though relatively significant numbers of studies are conducted on the genetics domain of this disease in the developed world, there is huge information gap in the sub-Saharan Africa region in general and in Eritrea in particular. Objective: The principal aim of this study was to investigate the association of common variants of the Insulin Receptor Substrate 1 (IRS1) and Transcription Factor 7-Like 2 (TCF7L2) genes with T2DM in the Eritrean population. Method: In this cross-sectional case control study 200 T2DM patients and 112 non-diabetes subjects were participated and genotyping of the IRS1 (rs13431179, rs16822615, 16822644rs, rs1801123) and TCF7L2 (rs7092484) tag SNPs were carries out using PCR-RFLP method of analysis. Haplotype analyses were carried out using Plink version 1.07, and Haploview 4.2 software. Linkage disequilibrium (LD), and Hardy-Weinberg equilibrium (HWE) analyses were performed using the Plink software. All descriptive statistical data analyses were carried out using SPSS (Version-20) software. Throughout the analysis p-value ≤0.05 was considered statistically significant. Result: Significant association was found between rs13431179 SNP of the IRS1 gene and T2DM under the recessive model of inheritance (OR=9.00, 95%CI=1.17-69.07, p=0.035), and marginally significant association found in the genotypic model (OR=7.50, 95%CI=0.94-60.06, p=0.058). The rs7092484 SNP of the TCF7L2 gene also showed markedly significant association with T2DM in the recessive (OR=3.61, 95%CI=1.70-7.67, p=0.001); and allelic (OR=1.80, 95%CI=1.23-2.62, p=0.002) models. Moreover, eight haplotypes of the IRS1 gene found to have significant association withT2DM (p=0.013 to 0.049). Assessments made on the interactions of genotypes of the rs13431179 and rs7092484 SNPs with various parameters demonstrated that high density lipoprotein (HDL), low density lipoprotein (LDL), waist circumference (WC), and systolic blood pressure (SBP) are the best T2DM onset predicting models. Furthermore, genotypes of the rs7092484 SNP showed significant association with various atherogenic indexes (Atherogenic index of plasma, LDL/HDL, and CHLO/HDL); and Eritreans carrying the GG or GA genotypes were predicted to be more susceptible to cardiovascular diseases onset. Conclusions: Results of this study suggest that IRS1 (rs13431179) and TCF7L2 (rs7092484) gene polymorphisms are associated with increased risk of T2DM in Eritreans.

Keywords: IRS1, SNP, TCF7L2, type 2 diabetes

Procedia PDF Downloads 194

Authors: Areeg Shermaddo

Abstract:

Solar updraft power plants (SUPP) provide a great potential for green and environmentally friendly renewable power generation. An up to 1000 m high chimney represents one of the major parts of each SUPP, which consist of the main shell structure and the stiffening rings. Including the nonlinear material behavior in a simulation of the chimney is computationally a demanding task. However, allowing the formation of cracking in concrete leads to a more economical design of the structure. In this work, an FE model of a SUPP is presented incorporating the nonlinear material behavior. The effect of wind loading intensity on the structural response is explored. Furthermore, the influence of the stiffness of the ring beams on the global behavior is as well investigated. The obtained results indicate that the minimum reinforcement is capable of carrying the tensile stresses provided that the ring beams are rather stiff.

Keywords: ABAQUS, nonlinear analysis, ring beams, SUPP

Procedia PDF Downloads 197

Authors: Areeg Shermaddo, Abedulgader Baktheer

Abstract:

Solar updraft power plants (SUPPs) made from reinforced concrete (RC) are an innovative technology to generate solar electricity. An up to 1000 m high chimney represents the major part of each SUPP ensuring the updraft of the warmed air from the ground. Numerical simulation of nonlinear behavior of such large mega shell concrete structures is a challenging task, and computationally expensive. A general finite element approach to simulate reinforced concrete bearing behavior is presented and verified on a simply supported beam, as well as the technique of submodeling. The verified numerical approach is extended and consecutively transferred to a more complex chimney structure of a SUPP. The obtained results proved the reliability of submodeling technique in analyzing critical regions of simple and complex mega concrete structures with high accuracy and dramatic decrease in the computation time.

Keywords: ABAQUS, nonlinear analysis, submodeling, SUPP

Procedia PDF Downloads 197