Search results for: Ali Ghoraba

Authors: Borna A. Assarian, Richard Imonikhe, Ali Ghoraba, Sameh A. Ibrahim, Marwa Albaroudi

Abstract:

Introduction: Glaucoma is characterised by increased intraocular pressure (IOP) and can cause irreversible vision loss if untreated. Selective laser trabeculoplasty (SLT) is a non-invasive treatment to lower IOP and slow glaucoma progression. The aim of this study was to evaluate the safety and efficacy of SLT in reducing IOP and the number of anti-glaucoma eye drops used in glaucoma patients at the University Hospital of Southampton. Method: Records of 100 eyes of glaucoma patients between 2020-2022 were reviewed. Pre- and post-treatment IOP and changes in the quantity of anti-glaucoma eye drops were analysed. Inclusion criteria required SLT treatment and IOP measurement with Goldmann applanation tonometry. Patients with adjustments made to anti-glaucoma drops before six weeks post-treatment or before IOP measurement were excluded. Results: 100 eyes of 62 glaucoma patients were studied and consisted of 60% primary open-angle glaucoma, 14% pigment dispersion syndrome, 11% ocular hypertension, 10% primary angle closure glaucoma, 4% normal-tension glaucoma, and 1% pseudoexfoliation syndrome. Overall, the average IOP reduction was 2.12 mmHg per eye. SLT was effective in reducing IOP across all types of glaucoma; degrees of effect were dependent on the type of pathology, with the greatest median decrease in primary open-angle glaucoma and ocular hypertension (3mmHg). IOP reduction also varied based on the number of anti-glaucoma eye drops used, with the largest median decrease (4mmHg) observed in patients who did not use any drops. SLT reduced the number of anti-glaucoma eye drops, with 10% of cases discontinuing use and 6% reduced by one eye drop. Adverse events were rare and included transient increases in IOP (2%) and corneal oedema (1%). Conclusion: SLT is a safe and effective treatment option for reducing IOP and the number of anti-glaucoma eye drops. The type of glaucoma and the number of anti-glaucoma eye drops used by patients can help predict the efficacy of SLT treatment.

Keywords: glaucoma, non-invasive treatment, raised intraocular pressure, selective laser trabeculoplasty

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Authors: Hamada Ahmed, Mervat A. Abdel-Latif, Alaa. A. Ghoraba, Samah A. Ganna

Abstract:

An experiment was conducted to determine the effect of microbial phytase (Quantum Blue®) supplementation on layer chickens fed diets with required or low phosphorous level in corn-soybean based diets. One hundred and sixteen 23-week-old Lohman brown laying hens were used in 8-week feeding trial. Hens were randomly allotted into four treatments where the group (1) (control group) was fed basal diet without phytase, group (2) fed basal diet supplemented with phytase, group (3) fed diet supplemented with phytase as a replacement of 25% of monocalcium phosphate and group (4) fed diet supplemented with phytase as a replacement of 50% of monocalcium phosphate. Records on daily egg production, egg mass, egg weight and body weight of hens at the end of experimental period were recorded. Results revealed no significant (p ≥ 0.05) differences were observed among the other dietary treatments in BW, egg production, egg mass, feed intake or feed conversion when these parameters were evaluated over the duration of the experiment while egg weight showed significant (p < 0.05) increase in all phytase supplemented groups. There was no significant (p ≥ 0.05) differences in egg quality including egg length, egg width, egg shape index, yolk height, yolk width, yolk index, yolk weight and yolk albumin ratio while egg albumin was significantly increased (p < 0.05) in group (2) and group (3). Egg shell weight increased significantly (p < 0.05) in all phytase supplemented groups when compared with the control group also shell thickness increased significantly (p < 0.05) in both group (2 &3). No significant (P ≥ 0.05) difference was observed in serum Ca, P level while alkaline phosphatase was significantly (P ˂ 0.05) increased in group (3). Egg shell analysis showed increase in egg shell ash% in all phytase supplemented groups when compared with the control group, egg shell calcium % was higher in group (3) and group (4) than the control group while group (2) showed lower egg shell calcium% than the other experimental groups, egg shell phosphorous% was higher in all phytase supplemented groups than the control group. Phosphorous digestability was significantly (P ˂ 0.05) increased in all phytase supplemented groups than the control group and the highest p digestability was in group (4). Calcium digestability showed significant (P ˂ 0.05) increase in all phytase supplemented groups when compared with the control group and the highest digetability was in group (4).

Keywords: layers, microbial phytase, Ca and P availability, egg production, egg characteristics

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