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Improving the Dissolution Rate of Folic Acid via the Antisolvent Vapour Precipitation

Authors: J. Y. Tan, L. C. Lum, M. G. Lee, S. Mansouri, K. Hapgood, X. D. Chen, M. W. Woo

Abstract:

Folic acid (FA) is known to be an important supplement to prevent neural tube defect (NTD) in pregnant women. Similar to some commercial formulations, sodium bicarbonate solution is used as a solvent for FA. This work uses the antisolvent vapour precipitation (AVP), incorporating ethanol vapour as the convective drying medium in place of air to produce branch-like micro-structure FA particles. Interestingly, the dissolution rate of the resultant particle is 2-3 times better than the particle produce from conventional air drying due to the higher surface area of particles produced. The higher dissolution rate could possibly improve the delivery and absorption of FA in human body. This application could potentially be extended to other commercial products, particularly in less soluble drugs to improve its solubility.

Keywords: Absorption, dissolution rate, folic acid, antisolvent vapour precipitation

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1097000

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References:


[1] J. Fife, S. Raniga, P. N. Hider, and F. A. Frizelle, “Folic acid supplementation and colorectal cancer risk: a meta-analysis,” Colorectal Disease, vol. 13, no. 2, pp. 132-137, 2011.
[2] K. Kanal, J. Busch-Hallen, T. Cavalli-Sforza, B. Crape, and S. Smitasiri, “Weekly iron-folic acid supplements to prevent anemia among Cambodian women in three settings: Process and outcomes of social marketing and community mobilization,” Nutrition Review, vol. 63, pp. S126-S133, 2005.
[3] F. V. Van Oort, A. Melse-Boonstra, I. A. Brouwer, R. Clarke, C. E. West, M. B. Katan, and P. Verhoef, “Folic acid and reduction of plasma homocysteine concentration in older adults: a dose-response study,” The American Journal of Clinical Nutrition, vol. 77, no. 5, pp. 1318-1323, 2003.
[4] R. Williamson, “Prevention of birth defects: Folic acid,” Biological Research for Nursing, vol. 3, no. 1, pp. 33-38, 2001.
[5] Anonymous, “Folic acid fortification,” Nutrition Reviews, vol. 54, no.3, pp. 94-95, 1996.
[6] H. S. Reisch, and M. A. T. Flynn, ‚Folic acid and the prevention of neural tube defects (NTDs): Challenges and recommendations for public health,” Canadian Journal of Public Health, vol. 93, no. 4, pp. 254-258, 2002.
[7] K. Giebe, and C. Counts, “Comparison of prenate advanceTM with other prescription prenatal vitamins: A folic acid dissolution study,” Adv. Therapy, vol. 17, no. 4, pp. 179-183, 2000.
[8] S. Mansouri, N. Fu, M. W. Woo, and X. D. Chen, “Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions,” Langmuir, vol. 28, no. 39, pp. 13772-13776, 2012.
[9] S. Mansouri, G. Q. Chin, T. W. Ching, M. W. Woo, N. Fu, and X. D. Chen, “Precipitating smooth amorphous or pollen structured lactose microparticles,” Chemical Engineering Journal, vol. 226, no. 0, pp. 312- 318, 2013.
[10] S. Mansouri, M. W. Woo, and X. D. Chen, “Making uniform whey, lactose, and composite lactose-whey particles from the dehydration of single droplets with antisolvent vapour,” Drying Technology, vol. 31, no. 13-14, pp. 1570-1577, 2013.
[11] J. Sun, F. Wang, Y. Sui, Z. She, W. Zhai, C. Wang, and Y. Deng, “Effect of particle size on solubility, dissolution rates, and oral bioavailability: Evaluation using coenzyme Q10 as naked nanocrystals,” International Journal of Nanomedicines, vol. 7, pp. 5733, 2012.
[12] P. Mohanachandran, P. Sindhumol, and T. Kiran, “Enhancement of solubility and dissolution rate: An overview,” International Journal of Comprehensive Pharmacy, vol. 4, no. 11, pp. 1-10, 2010.
[13] B. Johnson, and V. Kuna, “Water-soluble folic acid compostions,” Google Patents US6248361 B1, 2001.
[14] J. Shaw, “Cisplatin and folic acid administered to treat breast cancer,” Google Patents US6297245 B1, 2001.
[15] S. Qi Lin, X. D. Chen, “Improving the glass-filament method for accurate measurement of drying kinetics of liquid droplets,” Chemical Engineering Research and Design, vol. 80, no. 4, pp. 401-410, 2002.
[16] Y. Lin, S. R. Dueker, J. R. Follett, J. G. Fadel, A. Arjomand, P. D. Schneider, J. W. Miller, R. Green, B. A. Buchholz, J. S. Vogel, R. D. Phair, and A. J. Clifford, “Quantitative in vivo human folate metabolism,” The American Journal of Clinical Nutrition, vol. 80, no. 3, pp. 680-691, 2004.