Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30127
A Study on the Effects of Prolactin and Its Abnormalities on Semen Parameters of Male White Rats

Authors: Rizvi Hasan

Abstract:

Male factor infertility due to endocrine disturbances such as abnormalities in prolactin levels are encountered in a significant proportion. This case control study was carried out to determine the effects of prolactin on the male reproductive tract, using 200 male white rats. The rats were maintained as the control group (G1), hypoprolactinaemic group (G2), 3 hyperprolactinaemic groups induced using oral largactil (G3), low dose fluphenazine (G4) and high dose fluphenazine (G5). After 100 days, rats were subjected to serum prolactin (PRL) level measurements and for basic seminal fluid analysis (BSA). The difference between serum PRL concentrations of rats in G2, G3, G4 and G5 as compared to the control group were highly significant by Student’s t-test (p<0.001). There were statistically significant differences in seminal fluid characteristics of rats with induced prolactin abnormalities when compared with those of control group (p value <0.05), effects were more marked as the PRL levels rise.

Keywords: Male factor infertility, Prolactin, Seminal fluid analysis, animal studies.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1096389

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1705

References:


[1] P. J. Rowe, F. H. Comhaire, T.B. Hargreave and H. J. Mellows (eds), "WHO manual for the standardized investigation and diagnosis of the infertile couple”, Cambridge: Cambridge University Press, 1993.
[2] P. J. Rowe, E. M. Vikhlyaeve, Diagnosis and treatment of infertility. Toronto: Hans Huner Publishers, 1988.
[3] H. P. Azarian, T. S. Drampian, L. A. Tatevosian, "Main causes and frequency of male factor infertility in infertile couples,” in Diagnosis and treatment of infertility. P. J. Rowe aand E. M, Vikhlyaeva, Ed. Toronto: Hans Huner publishers, 1998. pp. 111-116.
[4] G. Nowakowaski, E. Widala, D. A. A. Kochanska, "Hyperprolactinaemia: Aetiopathogenesis and clinical features,” PrzeglLek, vol. 55, pp. 393-396, 1998.
[5] A. Coppola, M. A. Cuomo, "Prolactinoma in the male. Physiopathological, clinical and therapeutic features,” Minerva Endocrinology, vol. 23, pp. 7-16, 1998.
[6] G. V. P. Chamberlain, T. L. T. Lewis, Gynaecology by Ten Teachers, Somerset: Great Britain, 1995.
[7] D. M. Nudell, Male factor infertility and men’s health. Male infertility overview, pp. 1-5, 2003.
[8] A. Rogoza, W. Mierzejewski and M. Puzio, "Detection and treatment of hyperprolactinaemia in male infertility,” Ginekaol Pol., vol. 65, pp. 75- 79, 1994.