Periodontal Disease or Cement Disease? New Frontier in the Treatment of Periodontal Disease in Dogs

Authors: C. Gallottini, W. Di Mari, A. Amaddeo, K. Barbaro, A. Dolci, G. Dolci, L. Gallottini, G. Barraco, S. Eramo

Abstract:

A group of 10 dogs (group A) with Periodontal Disease in the third stage, were subjected to regenerative therapy of periodontal tissues, by use of nano hydroxy apatite (NHA). These animals induced by general anesthesia, where treated by ultrasonic scaling, root planning, and at the end by a mucogingival flap in which it was applied NHA. The flap was closed and sutured with simple steps. Another group of 10 dogs (group B), control group, was treated only by scaling and root planning. No patient was subjected to antibiotic therapy. After three months, a check was made by inspection of the oral cavity, radiography and bone biopsy at the alveolar level. Group A showed a total restitutio ad integrum of the periodontal structures, and in group B still mild gingivitis in 70% of cases and 30% of the state remains unchanged. Numerous experimental studies both in animals and humans have documented that the grafts of porous hydroxyapatite are rapidly invaded by fibrovascular tissue which is subsequently converted into mature lamellar bone tissue by activating osteoblast. Since we acted on the removal of necrotic cementum and rehabilitating the root tissue by polishing without intervention in the ligament but only on anatomical functional interface of cement-blasts, we can connect the positive evolution of the clinical-only component of the cement that could represent this perspective, the only reason that Periodontal Disease become a Cement Disease, while all other clinical elements as nothing more than a clinical pathological accompanying.

Keywords: Nanoidroxiaphatite, Parodontal Disease, Rigenerative Therapy.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1092864

References:

[1] Gallottini C, Barraco G, Dolci G, Edizioni Accademiche Italiane, 2013 – ISBN 978-3-639-47472-5 – New Frontiers in the Treatment of Parodontal Disease in Dogs.
[2] Pontoriero R, Nyman S, Ericsson I, Lindhe J. - J Clin Periodontol. 1992 Mar; 19(3): 159-63. Guided Tissue Regeneration in Surgically-Produced Furcation Defects. An Experimental Study in the Beagle Dog.
[3] Giargia M, Ericsson I, Lindhe J, Berglundh T, Neiderud AM.J Clin Periodontol. 1994 Aug; 21(7): 457-64. Tooth Mobility and Resolution of Experimental Periodontitis. An Experimental Study in the Dog.
[4] Lindhe J, Pontoriero R, Berglundh T, Araujo. J Clin Periodontol. 1995 Apr; 22(4): 276-83. The Effect of Flap Management and Bioresorbable Occlusive Devices in GTR Treatment of Degree III Furcation Defects. An Experimental Study in Dogs.
[5] Araújo M, Berglundh T, Lindhe J. J Clin Periodontol. 1996 Jun; 23(6):532-41. The Periodontal Tissues in Healed Degree III Furcation Defects. An Experimental Study in Dogs.
[6] J Clin Periodontol. 1997: 24: 738-746. M. G. Araujo, T. Berglundh and J. Lindhe. On the Dynamics of Periodontal Tissue Formation in Degree III Furcation Defects.
[7] J Clin Periodontol. 1998: 25: 524-530. M. G. Araujo and J. Lindhe. GTR Treatment of Degree III Furcation Defects Following Application of Enamel Matrix Proteins.
[8] M. G. Araujo, T. Berglundh and J. Lindhe. J Clin Periodontol. 1998: 25: 253-259. GTR treatment of Degree III Furcation Defects with 2 Different Resorbable Barriers.
[9] J Clin Periodontol. 1999; 26: 643–652. M. G. Araujo, T. Berglundh, T. Albrekstsson2 and J. Lindhe. Bone Formation in Furcation Defects.
[10] J Clin Periodontol. 2003: 29: 1122–1131. M. G. Araujo, M. Sonohara, R. Hayacibara, G. Cardaropoli andJ. Lindhe. Lateral Ridge Augmentation by the Use of Grafts Comprised of Autologous Bone or a Biomaterial. An Experiment in the Dog.
[11] J Clin Periodontol. 2003; 30: 855–861. M. Araujo, R. Hayacibara, M. Sonohara, G. Cardaropoli and J. Lindhe. Effect of enamel matrix proteins (Emdogains) on Healing After Re-Implantation of "Periodontally Compromised” Roots.
[12] J Clin Periodontol. 2004; 31: 845–849. N. U. Zitzmann, T. Berglundh, I. Ericsson2 and J. Lindhe. Pontaneous Progression of Experimentally Induced Periimplantitis.
[13] Clin. Oral Impl. Res. 2010; 21; 55–64. Araujo MG, Liljenberg B, Lindhe J. Dynamics of BioOsss Collagen Incorporation in Fresh Extraction Wounds: An Experimental Study in the Dog.
[14] Clin. Oral Impl. Res. 2010; 21; 445–454. Araujo MG, Liljenberg B, Lindhe J. b-Tricalcium Phosphate in the Early Phase of Socket Healing: An Experimental Study in the Dog.
[15] Clin. Oral Impl. Res. 2011; 22; 1–8. Araujo MG, Linder E, Lindhe J. Bio-Osss Collagen in the buccal gap at immediate implants: a 6-month study in the dog.
[16] Clin. Oral Impl. Res. 2011; 22; 9–13. Arau´ jo MG, Lindhe J. Socket Grafting with the Use of Autologous Bone: An Experimental Study in the Dog.
[17] Clin. Oral Impl. Res. 2012; 00; 1–6. Lindhe J, Araujo M. G, Bufler M, Liljenberg B. Biphasic Alloplastic Graft Used to Preserve the Dimension of the Edentulous Ridge.
[18] Holmes R, Mooney V, Bucholz R, et al.: A Coralline Hydroxylapatite Bone Graft Substitute. Clin Orthop. 1984; 188: 252-62
[19] Benqué EP, Gineste M, Heughebaert M: Etude Histologique de la Biocompatibilité des Cristaux d’Hydroxyapatite en Chirurgie Parodontale. J Biol Buccale. 1985; 13: 271-82
[20] Kent JN: Reconstruction of the Alveolar Ridge with Hydroxyapatite. Dent Clin North Am. 1986 Apr; 30 (2): 231-57
[21] Carranza FA Jr, Kenney EB, Lekovic V, Talamante E, Valencia J, Dimitrijevic B: Histologic Study of Healing of Human Periodontal Defects after Placement of Porous Hydroxylapatite Implants. J Periodontol. 1987 Oct; 58 (10): 682-8
[22] Donath K, Rohrer MD, Hormann K: Mobile and Immobile Hydroxyapatite Integration and Resorption and Its Influence on Bone. J Oral Implantol. 1987; 13 (1): 120-7
[23] Minegishi D, Lin C, Noguchi T, Ishikawa I: Porous Hydroxyapatite Granule Implants in Periodontal Osseous Defects in Monkeys. Int J Periodontics Restorative Dent. 1988; 8 (4): 50-63
[24] Boone PS, Zimmerman MC, Gutteling E, Lee CK, Parsons JR, Langrana N: Bone Attachment to Hydroxyapatite Coated Polymers. J Biomed Mater Res. 1989 Aug; 23 (A2 Suppl): 183-99.