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Bioprocess Optimization Based On Relevance Vector Regression Models and Evolutionary Programming Technique

Authors: R. Simutis, V. Galvanauskas, D. Levisauskas, J. Repsyte


This paper proposes a bioprocess optimization procedure based on Relevance Vector Regression models and evolutionary programming technique. Relevance Vector Regression scheme allows developing a compact and stable data-based process model avoiding time-consuming modeling expenses. The model building and process optimization procedure could be done in a half-automated way and repeated after every new cultivation run. The proposed technique was tested in a simulated mammalian cell cultivation process. The obtained results are promising and could be attractive for optimization of industrial bioprocesses.

Keywords: bioprocess optimization, Evolutionary programming, Relevance Vector Regression

Digital Object Identifier (DOI):

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