Design and Fabrication of Stent with Negative Poisson’s Ratio

Authors: S. K. Bhullar, J. Ko, F. Ahmed, M. B. G. Jun

Abstract:

The negative Poisson’s ratios can be described in terms of models based on the geometry of the system and the way this geometry changes due to applied loads. As the Poisson’s ratio does not depend on scale hence deformation can take place at the nano to macro level the only requirement is the right combination of the geometry. Our thrust in this paper is to combine our knowledge of tailored enhanced mechanical properties of the materials having negative Poisson’s ratio with the micromachining and electrospining technology to develop a novel stent carrying a drug delivery system. Therefore, the objective of this paper includes (i) fabrication of a micromachined metal sheet tailored with structure having negative Poisson’s ratio through rotating solid squares geometry using femtosecond laser ablation; (ii) rolling fabricated structure and welding to make a tubular structure (iii) wrapping it with nanofibers of biocompatible polymer PCL (polycaprolactone) for drug delivery (iv) analysis of the functional and mechanical performance of fabricated structure analytically and experimentally. Further, as the applications concerned, tubular structures have potential in biomedical for example hollow tubes called stents are placed inside to provide mechanical support to a damaged artery or diseased region and to open a blocked esophagus thus allowing feeding capacity and improving quality of life.

Keywords: Micromachining, electrospining, auxetic materials, enhanced mechanical properties.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1091366

References:

[1] Müller J. M.,Erasmi H., Stelzner M., Zieren U. and Pichlmaier H. 1990 Surgical Therapy of Oesophageal Carcinoma Br. J. Surg 77 845-57.
[2] SundelöfM, Ringby D, Stockled D, Gransröm, Jonas E and Freedom J 2007 Palliative Treatment of Malignant Dysphagia with Self-Expanding Metal Stents: A 12-Year Experience”, ScandJGastroenterol, 4211-16.
[3] Berry J L, Manoach E and Mekkaoui C 2002 Hemodynamics and Wall Mechanics of a Compliance Matching Stent: In Vitro and In Vivo Analysis”, J. Vasc. Interv. Radiol13 97–105.
[4] Bedoya J, Meyer CA and Timmins LH 2006 Effects of Stent Design Parameters on Normal Artery Wall Mechanics. J Biomech Eng.128 757–765.
[5] Lally C, Dolan F and Prendergast P J 2005 Cardiovascular Stent Design and Vessel Stresses a Finite Element Analysis J Biomech38 1574–1581.
[6] Holzapfel GA, StadlerM. and Gasser TC 2005 Changes in the Mechanical Environment of Stenotic Arteries during Interaction with Stents: Computational Assessment of Parametric Stent Designs Journal of Biomech Eng.127 166–180.
[7] Migliavacca F, Petrini L, Colombo M, Auricchio F and Pietrabissa R, 2002 Mechanical Behavior of Coronary Stents Investigated through the Finite Element Method Journal of Biomechanics35 803-811.
[8] Binzoni T, Leung T S, Boggett D and Delpy D T 2002 A New Near Infrared Laser-Doppler Flowmeterfor Deep Tissue Perfusion Monitoring MAGMA 14 74–75
[9] Murtaza NA and Ihtesham UR 2011 An AuxeticStructure Configured as Oesophageal Stent with Potential to Be Used for Palliative Treatment of OesophagealCancer; Development and in vitroMechanical Analysis J Mater Sci Mater Med222573–2581.
[10] Raamachandran J and Jayavenkateshwaran K 2007 Modeling of Stents Exhibiting Negative Poisson’s Ratio Effect Computational Methods Biomechanics Biomed. Eng., 2007; 10: 245–255.
[11] Bhullar SK, Mawanane AT Hewage, Alderson A, Aldersonand Martin BG Jun, 2013, Influence of Negative Poisson's Ratio on Stent ApplicationsAdvances in Materials, doi: 10.11648/j.am.20130203.14 2(3) 42-47.
[12] Conigliaro R, Battaglia G and Repici A 2007 PolyflexStents for Malignant Oesophagealand Oesophagogastric Strictures: A Prospective, Multicentric Study Eur J GastroenterolHepatol19 195–203.
[13] Eberhart RC, Su SH, Nguyen KT, Zilberman M, Tang L, Nelson KD and Frenkel P 2003 Review-BioresorbablePolymeric Stents: Current Status and Future Promise Journal of Biomaterials Science, Polymer Edition 14 299-312.
[14] Kastrati A, Mehilli J, Dirschinger J, Pache J, Ulm K, Schühlen H, Seyfarth M, Schmitt C, Blasini R, Neumann FJand Schömig A 2001 Restenosis After Coronary Placement of Various Stent Types,” American Journal of Cardiology87 34–39.
[15] Pan Y, Dong S, Hao Y, Chu T, Li C, Zhang Z and Zhou Y 2010 Demineralized Bone Matrix Gelatin as Scaffold for Tissue Engineering African Journal of Microbiology Research4 (9) 865-870.
[16] Morgan R and Adam A 2001 Use of Metallic Stents and Balloons in the Esophagus and Gastrointestinal Tract J VascIntervRadiol12 283–97.
[17] Kostopoulos PP, Zissis MI, Polydorou AA, Premchand PP, Hendrickse MT, Shorrock CJ and Isaacs PE 2003 Are Metal Stents Effective for Palliation of Malignant Dysphagia and Fistulas?Dig Liver Dis 35(4) 275-82
[18] Lakes R S 1987 Foam Structures with A negative Poisson's Ratio Science235 1038-1040.
[19] Lakes R S Design Considerations for Negative Poisson's Ratio Materials ASME J.Mech. Design115 696-700.
[20] Love A E H 1944 A Treatise on the Mathematical Theory of Elasticity (Dover: New York), p 163.
[21] Fung Y C 1968 Foundations of Solid Mechanics (Prentice-Hall), p 353.
[22] Caddock B D and Evans K E 1989Microporous Materials with Negative Poisson’s Ratios I: Microstructure and Mechanical Properties J. Phys. D: Appl. Phys.22 1877-1882.
[23] Gunton D J and Saunders G A 1972 The Young’s Modulus and Poisson’s Ratio of Arsenic, Antimony and Bismuth J.Mater. Sci7 1061-1068.
[24] Li Y, 1976 The Anisotropic Behavior of Poisson’s Ratio, Young’s Modulus, and Shear Modulus in Hexagonal Materials Physica Status Solidi A38 171-175.
[25] Yeganeh-Haeri Y, Weidner DJ and Parise JB 1992 Elasticity of Cristobalitea Silicon Dioxide with a Negative Poisson’s Ratio Science257 650-652.
[26] Veronda DR and Westmann RA 1970 Mechanical Characterization ofSkin Finite Deformations J. Biomech. 3 111-124
[27] Frohlich LM, Labarbera M and Stevens WP, 1994 Poisson’s Ratio of aCrossed Fibre Sheath: The Skin of Aquatic SalamandersJ. Zool. Lond. 232 231-252.
[28] Lees C, Vincent JEV and Hillerton JE 1991 Poisson’s Ratio in Skin Biomed. Mater. Eng.1 19-23.
[29] Williams JL and Lewis JL 1982 Properties and an Anisotropic Model of Cancellous Bone from the Proximal Tibial Epiphysis Trans. ASME, J. Biomech. Eng. 104 50-56.
[30] Liulan L, Qingxi H, Xianxu H and Gaochun X 2007 Design and Fabrication of Bone Tissue Engineering Scaxoolds via Rapid Prototyping and CAD Journal of Rare Earths25(2) 379-383.
[31] Pan Y, Dong S, Hao Y, Chu T, Li C, Zhang Z and Zhou Y 2010 Demineralized Bone Matrix Gelatin as Scaffold for Tissue Engineering African Journal of Microbiology Research4(9) 865-870.
[32] Yang W, Li ZM, Shi W, Xie BH and Yang MB 2004, Review on AuxeticmaterialsJournal of MaterialSciences 393269.79.
[33] Gaspar N, Smith CW, Miller EA, Seidler GT and Evans KE 2005 Quantitative Analysis of the Microscaleof Auxetic Foams. Phys Status Solidi242(2)550.60.
[34] Alderson A, Rasburn J, Evans KE and Grima JN 2001 AuxeticPolymeric Filters Display Enhanced De-Fouling and Pressure Compensation Properties Membrane Technology137 6-8.
[35] Grima JN, Jackson R, Anderson A and Evans KE 2000 Do Zeolites Have Negative Poisson's Ratios?,Adv. Materials12 1912-1918.
[36] Grima JN, Alderson A and Evans KE 2005 AuxeticBehaviourfrom Rotating Rigid Units phys. Stat. Sol. (b)242 561–575.