Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30135
Impact of Obesity on Fertility in a Population of Women in the Wilaya of Batna

Authors: A. Chennaf, M. Yahia, W. Bouafia, S. Benbia, D. Khellaf

Abstract:

Our study was designed to highlight changes in  certain biochemical parameters (CH, TG, HDL, GOT, GPT, LDL and  CRP), obese women infertile fertile witnesses and research potential  pathophysiological link between obesity and infertility in this  population of women. This practical work was focused on a  population of 24 obese women infertile, compared to controls,  subjects without any pathology causing disruption of parameters to  be studied to determine the contribution of obesity in the etiology of  infertility. The assay results revealed a highly significant difference  between the two groups in serum CH, TG, HDL, TGO and TGP (P  <0.0001) and in the rate of LDL (p = 0.0017) and CRP (p = 0.02).  The present study indicates that obesity is associated with infertility,  but no direct pathophysiological link between obesity and infertility  has been determined. Further in-depth studies are needed to  determine the exact mechanism by which overweight leads to female  infertility.

 

Keywords: Obesity, fertility, infertility, biochemical, women.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1090998

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1929

References:


[1] J. W. Rich-Edwards, D. Spiegelman, M. Garland, E. Hertzmark, D. J. Hunter, G. A. Colditz, W. C. Willett, J. E. W and H Manson, "Physical Activity, Body Mass Index and Ovulatory Disorder Infertility”, Epidemiology, 2002, pp. 13,184-190.
[2] R. Pasquali, L. Patton and A. Gambineri, "Obesity and Infertility”. Curr Opin Endocrinol Diabetes Obes, 2006, pp. 14, 482-7.
[3] J. F. Strauss, "The Synthesis and Metabolism of Steroid Hormones”. In: J. F. Strauss, R. L. Barbieri (eds). Yen and Jaffe’s Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management, 5th edn, Philadelphia, PA: Elsevier, 2004, pp. 12, 51-54.
[4] D. R. Illingworth, D. K. Corbin, E. D. Kemp, E. J. Keenan, "Hormone Changes during the Menstrual Cycles in Abeta-Lipoproteinemia: Reduced Luteal Phase Progesterone in a Patient with Homozygous Hypobeta-Lipoproteinemia”. Proc Natl Acad Sci, 1982, pp. 79, 6685- 6687.
[5] L. Speroff, R. H. Glass, N. G. Kase, "Progesterone in Human Pregnancy and Parturition” Clinical Gynecologic Endocrinology and Infertility, ED-5. Baltimore: Williams and Wilkins, USA, 1994, pp. 687-806.
[6] G. Hu, Q. Qiao, J. Tuomilehto et al, "Plasma Insulin and Cardiovascular Mortality in Non-Diabetic European Men and Women: A Meta-Analysis of Data from Eleven Prospective Studies”. The DECODE Insulin Study Group. Diabetologia, 2004, pp. 47, 1245–56.
[7] R. L. Barbieri, A. Makris, R. W. Randall, G. Daniels, R. W. Kistner, K. J. Ryan, "Insulin Stimulates Androgen Accumulation in Incubations of Ovarian Stroma Obtained from Women with Hyperandrogenism” . J Clin Endocrinol Metab, 1986, pp. 62,904 –10.
[8] S. Handwerger, et al, "Pre-beta-HDL Stimulates Placental Lactogen Release from Human Trophoblast Cells”. Am. J. Physiol, 1999, pp. 276, E384–E389.
[9] G.H. Rothblat et al, "Cell Cholesterol Efflux: Integration of Old and New Observations Provides New Insights”. J Lipid Res, 1999, pp. 40,781–796.
[10] M. Krieger, "Charting the Fate of the "Good Cholesterol: Identification and Characterization of the HDL Receptor SR-BI”. Ann. Rev.Biochem, 1999, pp. 68, 523–588.
[11] B. Trigatti et al, "Influence of the High Density Lipoprotein Receptor SR-BI on Reproductive and Cardiovascular Pathophysiology”. Proc. Natl. Acad. Sci. USA, 1999, pp. 96, 9322–9327.
[12] J. M. Clark, "The Epidemiology of Nonalcoholic Fatty Liver Disease in Adults”. J Clin Gastroenterol, 2006, pp. 40(3):S5–S10.
[13] J. Ludwig, R. T. Viggiano, D. B. McGill, "Nonalcoholic Steatohepatitis: Mayo Clinic Experience with a Hitherto Unnamed Disease”. Mayo Clin Proc, 1980, pp. 55,342–8.
[14] N. A. Khan, "Inflammation et Immunité: Implications Dans L’obésité et le Diabète de Type 2”. Oléagineux, Corps Gras, Lipides, 2006, pp. 13(5): 343-51.
[15] C.C. Kelly, H. Lyall, J.R Petrie, G.W Gould, J.M Connell, N. Sattar, "Low Grade Chronic Inflammation in Women with Polycystic Ovarian Syndrome”. J Clin Endocrinol Metab, 2001, pp. 86, 2453 –2455.