Impact of Hepatitis C Virus Chronic Infection on Quality of Life in Egypt

Authors: Ammal M. Metwally, Ghada A. Abdel-Latif, Walaa A. Fouad, Thanaa M. Rabah, Amira Mohsen, Fatma A. Shaaban, Iman I. Salama

Abstract:

The study aimed at determining the impact of chronic hepatitis C virus (HCV) infection on patients’ Quality of Life (QoL), its relation to geographical characteristics of patients, awareness of the disease, treatment regimen, co-morbid psychiatric or other diseases. 457 patients were randomly selected from ten National Treatment Reference Centers of Ministry of Health hospitals from four community locations representing Egypt. Health related QoL assessment questionnaire with the 36-item Short Form used for assessment of the enrolled patients. The study showed no significant difference between HCV patients in different governorates as regards total QoL. Females, illiterate patients and those had bilharziasis, diabetes mellitus, hypertension or were depressed had significantly the lowest QoL score. HCV patients who knew the danger of the disease had significant lower mean score of physical and mental health components. Optimal care of overall well-being of HCV patients requires adequate knowledge of their neurological and psychological status. It is important to know how to cope with having a family member with hepatitis C and more importantly to know what should you say and what shouldn’t you say as a positive hopeful attitude is essential for combating HCV chronic infection.

Keywords: Hepatitis C virus chronic infection, physical health component and mental health component of QoL, total quality of life.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1089441

References:

[1] Doss W., Mohamed M.K., Esmat G., El Sayed M., Fontanet A., Cooper S. and El Sayed N. Egyptian National Control Strategy for Viral Hepatitis 2008-2012. National Committee for the Control of Viral Hepatitis, Arab Republic of Egypt, Ministry of Health and Population. April 2008.
[2] Ibrahim E.M. and Madian A.A. Impact of Hepatitis C on Health-Related QoL in Egypt. Journal of American Science 2011;7(11):430-439]. (ISSN: 1545-1003).
[3] Bernstein D. (2003): Health Related QoL and Hepatitis C. © Hepatitis C Support Project. SUNY-Downstate School of Medicine
[4] Schwarzinger M., Dewedar S., Rekacewicz C., Abd Elaziz K.M., Fontanet A., Carrat F. and Mohamed M.K. Chronic hepatitis C virus infection: does it really impact health-related quality of life? A study in rural Egypt. Hepatology (Baltimore, Md.) (December, 40(6):1434-1441). Journal Article, Research Support, Non-U.S. Gov't.
[5] Sobhonslidsuk A., Silpakit C., Kongsakon R., Satitpornkul P., Sripetch C. and Khanthavit A. Factors influencing health-related quality of life in chronic liver disease, World J Gastroenterol.; 12(48): 7786-7791. December 28.
[6] Basal A.A., Kamel E. and Nafady H. (2011): Studying the Quality of Life of Chronic Hepatitis C Patients and the Associated Factors. Journal of American Science,7(12) http://www.americanscience.org
[7] Mathew A., Peiffer L.P., Rhoades K. and McGarrity T.J. Improvement in QoL measures in patients with refractory hepatitis C, responding to re-treatment with Pegylated interferon alpha -2b and ribavirin. Health and QoL Outcomes 2006, 4:30 doi:10.1186/1477-7525-4-30. © 2006 Mathew et al; licensee BioMed Central Ltd.
[8] Bezemer G., Gool A.R.V., Verheij-Hart E., Hansen B.E., Lurie Y., Esteban J.I., Lagging M., Negro F., Zeuzem S., Ferrari C., Pawlotsky J., Neumann A.U., Schalm S.W. and de Knegt R.J. Long-term effects of treatment and response in patients with chronic hepatitis C on QoL. An international, multicenter, randomized, controlled study. For the DITTO-HCV Study Group. BMC Gastroenterology 2012, 12:11. http://www.biomedcentral.com/1471-230X/12/11
[9] Porter L.K. Hepatitis C and QoL. ©2012 Hepatitis C Trust. www.hcvadvocate.org
[10] Queensland Health. QoL Among People Living with Chronic Hepatitis C Infection. File Ref No: 0055-4757-034. April, 2003.
[11] Foster G.R. QoL considerations for patients with chronic hepatitis C: "SVR improves long-term prognosis & health-related QoL - mental health, physical & general health/virality, emotional health". Journal of Viral Hepatitis Aug 2009.
[12] Amodio P., Salari L., Montagnese S., Schiff S., Neri D., Bianco T., Minazzato L. Hepatitis C virus infection and health-related QoL. World J Gastroenterol 2012 May 21; 18(19): 2295-2299. ISSN 1007-9327 (print) ISSN 2219-2840 (online). © 2012 Baishideng. All rights reserved.
[13] Hsu P.C., Krajden M., Yoshida E.M., Anderson F.H., Tomlinson G.A. and Krahn M.D. Does cirrhosis affect QoL in hepatitis C virus-infected patients? CLINICAL STUDIES. Liver International ISSN 1478-3223, Mar; 29 (3):449-58. © Blackwell Publishing Ltd.
[14] Strauss E. and Dias Teixeira MC. (2006): QoL in hepatitis C. Liver Int. 2006 Sep; 26(7):755-65. Brazil. [email protected]
[15] Abdo A.A. Hepatitis C and poor QoL: Is it the virus or the patient? Saudi J Gastroenterol 2008;14:109-13 Issue : 3. (cited 2012 Dec 14);from: http://www.saudijgastro.com/text.asp?2008/14/3/109/41727
[16] Hassanein T., Cooksley G., Sulkowski M., Smith C., Marinos G., Lai M.Y., Pastore G., Trejo-Estrada R., Horta E., Vale A., Wintfeld N. and Green J. The impact of peginterferon alfa-2a plus ribavirin combination therapy on health-related QoL in chronic hepatitis C. J Hepatol 2004, 40:675-681.
[17] Jafferbhoy H., Gashau W. and Dillon J.F. Cost effectiveness and QoL considerations in the treatment of hepatitis C infection. Dovepress Journal. 13July2010.
[18] Spiegel B.M.R., Younossi Z.M., Hays R.D., Revicki D., Robbins S. and Kanwal F. Impact of Hepatitis C on Health Related QoL: A Systematic Review and Quantitative Assessment. HEPATOLOGY, Vol. 41, No. 4, 2005