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Study of the Antimicrobial Activity of Aminoreductone against Pathogenic Bacteria in Comparison with Other Antibiotics

Authors: Vu Thu Trang, Lam Xuan Thanh, Samira Sarter, Tomoko Shimamura, Hiroaki Takeuchi 

Abstract:

Antimicrobial activities of aminoreductone (AR), a product formed in the initial stage of Maillard reaction, were screened against pathogenic bacteria. A significant growth inhibition of AR against all 7 isolates (Staphylococcus aureus ATCC® 25923™, Salmonella typhimurium ATCC® 14028™, Bacillus cereus ATCC® 13061™, Bacillus subtilis ATCC® 11774™, Escherichia coli ATCC® 25922™, Enterococcus faecalis ATCC® 29212™, Listeria innocua ATCC® 33090™) were observed by the standard disc diffusion methods. The inhibition zone for each isolate by AR (2.5 mg) ranged from 15±0mm to 28.3±0.4mm in diameter. The minimum inhibitory concentration (MIC) of AR ranging from 20mM to 26mM was proven in the 7 isolates tested. AR also showed the similar effect of growth inhibition in comparison with antibiotics frequently used for the treatment of infections bacteria, such as amikacin, ciprofloxacin, meropennem and levofloxacin. The results indicated that foods containing AR are valuable sources of bioactive compounds towards pathogenic bacteria.

Keywords: Pathogenic Bacteria, Antimicrobial activity, aminoreductone, Maillard reaction

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1089347

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References:


[1] M. A. J. S. van Boekel, "Effect of heating on Maillard reactions in milk,” Food Chem., vol. 62, May 1998, pp. 403-414.
[2] M. Pischetsrieder, C. Schoetter, and T. Severin, "Formation of an aminoreductone during the Maillard reaction of lactose with Nα-acetyllysine or proteins,” J. Agric. Food Chem., vol. 46, Feb. 1998, pp. 928-931.
[3] T. Shimamura, H. Ukeda, and M. Sawamura, "Relationship between the XTT reducibility and aminoreductone formed during the Maillard reaction of lactose: the detection of aminoreductone by HPLC,” Food Sci. Technol. Res., vol. 10, 2004, pp. 6-9.
[4] M. Pischetsrieder, F. Rinaldi, U. Gross, and T. Severin, "Assessment of the antioxidantive and prooxidative activities of two aminoreductones formed during Maillard reaction: Effects on the oxidation of β-Carotene, Nα-Acetylhistidine, and cis-Alkenes,” J. Agric. Food Chem., vol. 46, Feb. 1998, pp. 2945-2950.
[5] V. T. Trang, H. Takeuchi, H. Kudo, A. Aoki, S. Katsuno, T. Shimamura, T. Sugiura, and H. Ukeda. "Antimicrobial activity of aminoreductone against Helicobacter pylori.” J. Agric. Food Chem., vol. 57, Sep. 2009, pp. 11343–11348.
[6] H. Harbottle, S. Thakur, S. Zhao, and D. G. White, "Genetics of Antimicrobial Resistance,” Anim. Biotechnol. vol. 17, Sep. 2006, pp. 111-124.
[7] R. Khan, B. Islam, M. Akram, S. Shakil, A. Ahmad, S. M. Ali, M. Siddiqui, and A. U.Khan, " Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical origin,” Molecules, vol. 14, Jan. 2009, pp. 586-597.
[8] H. Takeuchi, T. Nakazawa, T. Okamoto, M. Shirai, M. Kimoto, M. Nishioka, S. Con, N. Morimoti, and T. Sugiura, "Cell elongation and cell death of Helicobacter pylori is modulated by the disruption of cdrA (Cell division-related gene A),” Microbiol. Immunol. vol. 50, Jul. 2006, pp. 487-497.
[9] H. Ukeda, T. Shimamura, T. Hosakawa, Y. Goto, and M. Sawamura, "Monitoring of the Maillard reaction based on the reduction of tetrazolium salt XTT,” Food Sci. Technol Int, vol. 4, 1998, pp. 258-263.
[10] V. Trang, Y. Kurogi, S. Katsuno, T. Shimamura, and H. Ukeda, "Protective effect of aminoreductone on photo-degradation of riboflavin,” Int. Dairy J. vol. 18, Dec. 2008, pp. 344-348.
[11] K. Mori, C. Maru, K. Takasuna, K. Furuhama, "Mechanism of histamine release induced by levofloxacin, a fluoroquinolone antibacterial agent,” Eur. J. Pharmacol., vol. 394, Mar. 2000, 51-55.
[12] T. Darville, "Imipenem and Meropenem,” Seminars Ped. Infect. Diseases, vol. 10, 1999, pp. 38-44.
[13] D. Carrier, N. Chartrand, and W. Matar, "Comparison of the effects of amikacin and kanamycins A and B on dimyristoylphosphatidylglycerol bilayers,” Biochem. Pharmacol., vol. 53, Jun.1997, pp. 401-408.
[14] G. Adwan, and M. Mhanna, "Synergistic effects of plant extracts and antibiotics on Staphylococcus aureus strains isolated from clinical specimens,” Middle-East J. Sci. Res., vol. 3, 2008, pp. 134-139.