PET/CT Patient Dosage Assay

Authors: Gulten Yilmaz, A. Beril Tugrul, Mustafa Demir, Dogan Yasar, Bayram Demir, Bulent Buyuk

Abstract:

A Positron Emission Tomography (PET) is a radioisotope imaging technique that illustrates the organs and the metabolisms of the human body. This technique is based on the simultaneous detection of 511 keV annihilation photons, annihilated as a result of electrons annihilating positrons that radiate from positron-emitting radioisotopes that enter biological active molecules in the body. This study was conducted on ten patients in an effort to conduct patient-related experimental studies. Dosage monitoring for the bladder, which was the organ that received the highest dose during PET applications, was conducted for 24 hours. Assessment based on measuring urination activities after injecting patients was also a part of this study. The MIRD method was used to conduct dosage calculations for results obtained from experimental studies. Results obtained experimentally and theoretically were assessed comparatively.

Keywords: PET/CT, TLD, MIRD, Dose measurement, Patient doses.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1089100

References:

[1] Brix, G., Lechel, U., Glatting, G., Ziegler, S.I., Münzing, W., Muller, S.P., Beyer T., "Radiation Exposure of Patients Undergoing Whole-Body Dual-Modality 18F-FDG/CT Examinations”, Journal of Nuclear Medicine; 46 No.4 pp.608-613, 2005.
[2] L. Gonzalez, C.A. Cordeiro, E. Vano, M. J. Perez Castejon, A. Jimenez, H. R. Montz, M. Domper, J. L. Carreras, " Patient Surface Radiation Doses At Two Pet Imaging Facilities”. Health Physics Societ,. vol. 84 No.4, pp.451-456, 2003.
[3] B. Guillet, P. Quentin, S. Waultier, M. Bourrelly, P. Pisano, O. Mundler, (2005). "Technologist radiation exposure in routine clinical practice with 18F-FDG PET”, Journal of Nuclear Medicine Technology, vol.33, No.3, pp.175- 179, 2005.
[4] D. W. Townsend, "Positron Emission Tomography/Computed Tomography” Elsevier, vol.38, No. 3, pp. 152-166, 2008.
[5] J.M.M. Climent, I. Peñuelas,. "Occupational Dosimetry In A Pet Center Due To Radionuclide Production And Medical Use. Nuclear Medicine Service. University Hospital.” University of Navarra. Pamplona. Spain. 2001.
[6] M. T. Dowd, C. Chen, M. J. Wendel, P. J. Faulhaber, M. D. Cooper, "Radiation Dose to the Bladder Wall from 2-
[18F] Fluoro-2- deoxy-Dglucose in Adult Humans”, Nuclear Medicine; vol.32 pp.707-712, 1991.
[7] M. G. Stabin, G. D. Flux "Internal dosimetry as a tool for radiation protection of the patient in nuclear medicine”, Biomedical Imaging and Intervention Journal, vol. 3, No. 2, pp.28, 2007.
[8] M. G. Stabin, "Proposed Addendum to Previously Published Fetal Dose Estimate Tables for 18F-FDG” Journal Of Nuclear Medicine; vol.45, No. 4, 2004.
[9] G. Yilmaz, "Phantom improvement for dose determination of positron emission tomography (PET), evaluation of MIRD and Marinelli methods and ascertain of a new geometry factor for absorbed dose”, PhD Thesis, Istanbul Technical University, 2010 (in Turkish and unpublished).
[10] H. M. Deloar, T. Fujiwara, M. Shidahara, T. Nakamura, H Watabe, Y. Narita, M. Itoh, M. Miyake, S. Watanuki, " Estimation of absorbed dose for 2-
[F-18]fluoro-2-deoxy-D-glucose using whole-body positron emission tomography and magnetic resonance imaging”. European Journal of Nuclear Medicine; pp.565-574, 1998.
[11] H. M. Deloar, T. Fujiwara,, M. Shidahara, T. Nakamura, A. Yamadera, M. Itoh, "Internal Absorbed Doze Estimation by a TLD Method For 18F-FDG and Comparison With the Dose Estimates From Whole Body PET”, Physical Medicine Biology, vol.44 No.2,pp. 595-606, 1999.
[12] D. Yaşar, A. B. Tuğrul, "A New Approach for the Calculation of Critical Organ Dose in Nuclear Medicine Applications”, Applied Radiation and Isotopes, vol.62 pp.405-410, 2005.
[13] D. Yaşar, A.B. Tuğrul, "A Comparision of TLD Measurements to MIRD Estimates of The Liner and Spleen”, Radiation Measurements, vol. 37, pp.113-118, 2003.
[14] W.S. Snyder, M.R. Ford, G.G. Warner, S.B. Watson, "Absorb dose per unit cumulated activity for selected radionuclides and organs”, nm/mird Pamphlet No 11. 1975.
[15] ICRP, (1991). ICRP Publication 60: "Recommendidation of the International Commission on Radiological Protection”, Pergammon Press, Oxford, 1991.