Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30169
A Novel Microarray Biclustering Algorithm

Authors: Chieh-Yuan Tsai, Chuang-Cheng Chiu


Biclustering aims at identifying several biclusters that reveal potential local patterns from a microarray matrix. A bicluster is a sub-matrix of the microarray consisting of only a subset of genes co-regulates in a subset of conditions. In this study, we extend the motif of subspace clustering to present a K-biclusters clustering (KBC) algorithm for the microarray biclustering issue. Besides minimizing the dissimilarities between genes and bicluster centers within all biclusters, the objective function of the KBC algorithm additionally takes into account how to minimize the residues within all biclusters based on the mean square residue model. In addition, the objective function also maximizes the entropy of conditions to stimulate more conditions to contribute the identification of biclusters. The KBC algorithm adopts the K-means type clustering process to efficiently make the partition of K biclusters be optimized. A set of experiments on a practical microarray dataset are demonstrated to show the performance of the proposed KBC algorithm.

Keywords: Microarray, Biclustering, Subspace clustering, Meansquare residue model.

Digital Object Identifier (DOI):

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1268


[1] J. L. DeRisi, V. R. Iyer, and P. O. Brown, 1997. "Exploring the metabolic and genetic control of gene expression on a genomic scale," Science, vol. 278, pp. 680-686, 1997.
[2] Y. Cheng and G. M. Church, "Biclustering of expression data," in Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, pp. 93-103, 2000.
[3] S. C. Madeira and A. L. Oliveira, "Biclustering algorithms for biological data analysis: A survey," IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 1, pp.24-45, 2004.
[4] D. P. Berrer, W. Dubitzky and M. Granzow, A Practical Approach to Microarray Data Analysis. Kluwer, Norwell, pp. 15-19, 2003.
[5] L. Parsons, E. Haque and H. Liu, "Subspace clustering for high dimensional data: A review," SIGKDD Explorations, vol. 6, pp. 90-105, 2004.
[6] H. Frigui and O. Nasraoui, "Unsupervised learning of prototypes and attribute weights," Pattern Recognition, vol. 37, pp. 567-581, 2004.
[7] J. B. MacQueen, "Some methods for classification and analysis of multivariate observations," in Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, pp. 281-297, 1967.
[8] K. Bryan, P. Cunningham and N. Bolshakova, "Application of simulated annealing to the biclustering of gene expression data," IEEE Transactions on Information Technology in Biomedicine, vol. 10, pp. 519-525, 2006.
[9] J. Yang, W. Wang, H. Wang and P. Yu, "╬┤-clusters: Capturing subspace correlation in a large data set," in Proceedings of the 18th IEEE International Conference on Data Engineering, pp. 517-528, 2002.
[10] J. Yang, H. Wang, W. Wang and P. Yu, "Enhanced biclustering on expression data," in Proceedings of the Third IEEE Symposium on BioInformatics and Bioengineering, pp. 1-7, 2003.
[11] A. Tanay, R. Sharan and R., Shamir, "Discovering statistically significant biclusters in gene expression data," Bioinformatics, vol. 18, pp. 136-144, 2002.
[12] S. Mitra and H. Banka, "Multi-objective evolutionary biclustering of gene expression data," Pattern Recognition, vol. 39, pp. 2464-2477, 2006.
[13] M. Filippone, F. Masulli, S. Rovetta, S. Mitra and H. Banka, "Possibilistic approach to biclustering: An application to oligonucleotide microarray data analysis," Lecture Notes in Computer Science, vol. 4210, pp. 312-322, 2006.
[14] S. Mitra, H. Banka and J. H. Paik, "Evolutionary fuzzy biclustering of gene expression data," Lecture Notes in Artificial Intelligence, vol. 4481, pp. 284-291, 2007.
[15] C. E. Shannon, "A mathematical theory of communication," The Bell System Technical Journal, vol. 27, pp. 379-423, 623-656, 1948.
[16] R. J. Cho, M. J. Campbell, E. A. Winzeler, L. Steinmetz, A. Conway, L. Wodicka, T. G. Wolfsberg, A. E. Gabrielian, D. Landsman, D. J. Lockhart and R. W. Davis, "A genome-wide transcriptional analysis of the mitotic cell cycle," Molecular Cell, vol. 2, pp. 65-73, 1998.
[17] P. T. Spellman, G. Sherlock, M. Q. Zhang, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein and B. Futcher, "Comprehensive identification of cell cycle regulated genes of the yeast Saccharomyces Cerevisiae by microarray hybridization," Molecular Biology of the Cell, vol. 9, pp. 3273-3297, 1998.