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Coherence Analysis for Epilepsy Patients: An MEG Study

Authors: S. Ge, T. Wu, HY. Tang, X. Xiao, K. Iramina, W. Wu


It is crucial to quantitatively evaluate the treatment of epilepsy patients. This study was undertaken to test the hypothesis that compared to the healthy control subjects, the epilepsy patients have abnormal resting-state connectivity. In this study, we used the imaginary part of coherency to measure the resting-state connectivity. The analysis results shown that compared to the healthy control subjects, epilepsy patients tend to have abnormal rhythm brain connectivity over their epileptic focus.

Keywords: Coherence, connectivity, resting-state, epilepsy

Digital Object Identifier (DOI):

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[1] M. Hampson, B.S. Peterson, P. Skudlarski, J.C. Gatenby, J.C. Gore, "Detection of functional connectivity using temporal correlations in MR images, " Hum Brain Mapp., 15, pp.247-262, 2002.
[2] C.F. Beckmann, M. DeLuca, J.T. Devlin, S.M. Smith, "Investigations into resting-state connectivity using independent component analysis," Philos Trans R Soc Lond B Biol Sci, 360, pp.1001-1013, 2005.
[3] W.W. Seeley, V. Menon, A.F. Schatzberg, J. Keller, G.H. Glover, H. Kenna, A.L. Reiss, M.D. Greicius, "Dissociable intrinsic connectivity networks for salience processing and executive control," J Neurosci, 27, pp.2349-2356, 2007.
[4] M.E. Raichle, A.M. MacLeod, A.Z. Snyder, W.J. Powers, D.A. Gusnard, G.L. Shulman, "A default mode of brain function," Proc Natl Acad Sci USA, 98, pp.676-682, 2001.
[5] M.D. Greicius, B. Krasnow, A.L. Reiss, V. Menon, "Functional connectivity in the resting brain: A network analysis of the default mode hypothesis," PNAS, 7, 100(1), pp.253-258, 2003.
[6] M.D. Greicius, K. Supekar, V. Menon, R.F. Dougherty, "Resting-state functional connectivity reflects structural connectivity in the default mode network," Cerebral Cortex, 19, pp.72-78, 2009.
[7] M. Lowe, E. Beall, K. Sakaie, K. Koenig, L. Stone, R. Marrie, M. Phillips, "Resting state sensorimotor functional connectivity in multiple sclerosis inversely correlates with transcallosal motor pathway transverse diffusivity," Hum Brain Mapp., 29(7), pp.818-827, 2008.
[8] T. Harmony, E. Marosi, T. Fernández, J. Bernal, J. Silva, M. Rodríguez, A. Reyes, A. Fernández-Bouzas, M. Alonso, R. Mendizábal R,et al., "EEG coherences in patients with brain lesions," Int J Neurosci, 74, pp.203-226, 1994.
[9] F. Bartolomei, I. Bosma, M. Klein, J.C. Baayen, J.C. Reijneveld, T.J. Postma, J.J. Heimans, et al, "How do brain tumors alter functional connectivity? A magnetoencephalography study," Ann Neurol, 59, pp.128-138, 2006.
[10] P.L. Nunez, R. Srinivasan, A.F. Westdorp, R.S. Wijesinghe, D.M. Tucker, R.B. Silberstein, P.J. Cadusch, "EEG coherency. I: Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales," Lectroencephalogr Clin Neurophysiol, 103, pp.499-515, 1997.
[11] G. Nolte, O. Bai, L. Wheaton, Z. Mari, S. Vorbach, M. Hallett, "Identifying true brain interaction from EEG data using the imaginary part of coherency," Clin Neurophysiol, 115, pp.2292-2307, 2004.
[12] T. Medkour, A.T. Walden, A.P. Burgess, "Graphical modelling for brain connectivity via partial coherence," J Neurosc. Methods, 180, pp.374-383, 2009.
[13] P.D. Welch, "The use of fast Fourier transform for the estimation of power spectra: a method based on time averaging over short, modified periodograms," IEEE Trans Audio Electroacoust, AU-15, pp.70-73, 1967.
[14] A.M. Siegel, B.C. Jobst, V.M. Thadani, C.H. Rhodes, P.J. Lewis, D.W. Roberts, P.D. Williamson, "Medically intractable, localization-related epilepsy with normal MRI: presurgical evaluation and surgical outcome in 43 patients," Epilepsia, 42, 7, pp.883-888, 2001.