Characterization of Liver Leukocyte Infiltrates and Features of Cytokine Profile under Viral Hepatitis-Induced Immunosuppression

Authors: Olga V. Lebedinskaya, Irina N. Kabanovskaya, Anna S. Lasareva, Nelly K. Akhmatova, Anatoliy P. Godovalov, Andrey V. Horinko, Mikhail V. Kiselevsky

Abstract:

The nature, prevalence, cellular composition of leukocyte infiltrates and immunohistochemical characteristics of their constituent cells in the liver of patients with chronic viral hepatitis B and C were investigated. It was found that the area of distribution and cellular composition of infiltrates depended on the virus type and process activity. The expediency of immunohistochemical study using leukocyte infiltrates from liver biopsies of patients with viral hepatitis aimed at clarifying diagnosis, making prognosis, and choice of optimal treatment with elements of immune correction is emphasized.

Keywords: Viral hepatitis, leukocyte infiltration, immunohistochemical characteristics, immunosupression.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1072189

References:

[1] K.H. Meyer zum Buschenfelde "Immunopathology of chronic liver diseases ", Verh. Dtsch. Ges. Pathol., vol. 79, 1995, pp. 186-197.
[2] M. Muller, H.E. Blum, F. Er, R. Thimme, N. Semmo "Cellular immune response in hepatitis C infection: Role of CD154 expression and clinical relevance", Dtsch. Med. Wochenschr., vol. 136(20), 2011, pp. 1073- 1077.
[3] A. Weber, Y.T. Boege, F. Reisinger, M. Heikenwälder "Chronic liver inflammation and hepatocellular carcinoma: persistence matters", Swiss. Med. Wkly., vol. 141, 2011, pp. 1-9