Commenced in January 2007
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Simulating Action Potential as a Linear Combination of Gating Dynamics

Authors: S. H. Sabzpoushan


In this research we show that the dynamics of an action potential in a cell can be modeled with a linear combination of the dynamics of the gating state variables. It is shown that the modeling error is negligible. Our findings can be used for simplifying cell models and reduction of computational burden i.e. it is useful for simulating action potential propagation in large scale computations like tissue modeling. We have verified our finding with the use of several cell models.

Keywords: linear model, action potential, gating dynamics

Digital Object Identifier (DOI):

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[1] AL.Hodgkin and AF.Huxley, "A quantitative description of membrane current and its Application to conduction and excitation in nerve". J Physiol (Lond) 117(1952) 500-544.
[2] D.Noble, A.Varghese, P. Kohl, P.J Noble. "Improved guinea pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes". Can J Cardiol 14(1998) 123- 134.
[3] S.H Sabzpoushan, A. Ayatollahi, D.Noble, P.J. Noble, "A survey on linear relations between main electrical components during action potential in ventricular cell", Applied mathematics and computation, 188 (2007) 148-153.
[4] COR (Cellular Open Resource).
[5] CellML.
[6] K.TenTusscher, A.V.Panfilov, "Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions", Phys.Med.Biol.51 (2006) 6141-6156
[7] O.Bernus, R.Wilders, C.W.Zemlin, H.Verschelde, A.V.Panfilov, "A computationally efficient electrophysiological model of human ventricular cells", Am J physiol Heart Circ Physiol 282 (2002) 2296- 2308.