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The Effect of Electrical Stimulation Intensity on VEGF Expression and Biomechanical Properties during Wound

Authors: M R Asadi, G Torkaman, M Hedayati


We evaluated the effect of sensory (direct current (DC), 600μA) and motor (monophasic current, pulse duration 300μs, 100 Hz, 2.5-3mA) intensities of cathodal electrical stimulation (ES) current to release VEGF and biomechanical properties of wound. 54 male Sprague-dawley rats were randomly assigned into one control and two experimental groups. A full thickness skin incision was made on animals- dorsal region. The experimental groups received ES for 1h/day and every other day. VEGF expression was measured in skin on the 7th day after surgical incision and tensile strength was measured on 21st day. On the 7th day, the values of skin VEGF in the sensory group were significantly greater than those of the other groups (p < 0.05). Sensory and Motor intensity stimulation, can not improve the biomechanical properties of the repaired wounds. It seems the mechanical environment induced by sensory and motor intensity of electrical stimulation, could not simulate the role of normal daily stress and strain to maturation of collagen fibers and their cross links. Further work is needed to determine the relationship between VEGF expression after ES and its effect on tensile strength of healed wound.

Keywords: Biomechanical properties Direct current, Monophasic current, Skin, VEGF

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[1] P. Bao , A.Kodra , M.Tomic-Canic , M.S. Golinko, H.P. Ehrlich, H. Brem," The role of vascular endothelial growth factor in wound healing", J Surge Res. vol. 153, no. 2, pp. 347-358, 2009.
[2] K.A. Morris, M.F. McGee, J.J. Jasper, K.M. Bogie. "Evaluation of electrical stimulation for ischemic wound therapy: a feasibility study using the lapine wound model", Arch Dermatol Res. Vol. 301, no. 4, pp. 323-327, 2009.
[3] M. Zhao, H. Bai, E. Wang, J.V. Forrester, C.D. McCaige, " CD. Electrically stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors", J cell Sci. no. 117, pp. 397-405, 2004.
[4] G. Talebi, G. Torkaman, M. Firoozabadi, S. Shariat, " Effect of anodal and cathodal micro-amperage direct current on the skin wound healing: A biomechanical and histological study", Journal of biomechanics, no. 40(s2), p. s665, 2007.
[5] L.C. Kloth, J.M. McCulloch, "Promotion of wound healing with electrical stimulation", Adv Wound care. Vol. 9, no. 5, pp. 42-45, 1996.G. O. Young, "Synthetic structure of industrial plastics (Book style with paper title and editor)," in Plastics, 2nd ed. vol. 3, J. Peters, Ed. New York: McGraw-Hill, 1964, pp. 15-64.