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Blood Cell Dynamics in a Simple Shear Flow using an Implicit Fluid-Structure Interaction Method Based on the ALE Approach
Abstract:A numerical method is developed for simulating the motion of particles with arbitrary shapes in an effectively infinite or bounded viscous flow. The particle translational and angular motions are numerically investigated using a fluid-structure interaction (FSI) method based on the Arbitrary-Lagrangian-Eulerian (ALE) approach and the dynamic mesh method (smoothing and remeshing) in FLUENT ( ANSYS Inc., USA). Also, the effects of arbitrary shapes on the dynamics are studied using the FSI method which could be applied to the motions and deformations of a single blood cell and multiple blood cells, and the primary thrombogenesis caused by platelet aggregation. It is expected that, combined with a sophisticated large-scale computational technique, the simulation method will be useful for understanding the overall properties of blood flow from blood cellular level (microscopic) to the resulting rheological properties of blood as a mass (macroscopic).
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1333450Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1954
 Goldsmith, H., Turitto, V., 1986. Rheological aspects of thrombosis and haemostasis: basic principles and applications. ICTH-Report-Subcommittee on Rheology of the International committee on thrombosis and haemostasis. Thrombosis and Haemostasis 55, 415-435.
 Miyazaki, H., Yamaguchi, T., 2003. Formation and destruction of primary thrombi under the influence of blood flow and von willebrand factor analysed by a D.E.M. Biorheology 40, 265-272.
 Wootton, D., Ku, D., 1999. Fluid mechanics of vascular systems, diseases, and thrombosis. Annual Review of Biomedical Engineering 1, 299-329.
 Chien, S., Usami, S., Skalak, R., 1984. Blood flow in small tubes. In: Handbook of Physiology-The Cardiovascular System IV, pp. 217-249.
 Shiga, T., Maeda, N., Kon, K., 1990. Erythrocyte rheology. Critical Review in Oncology/Hematology 10, 9-48.
 Pries, A., Neuhaus, D., Gaehtgens, P., 1992. Blood viscosity in tube flow: dependence on diameter and hematocrit. American Journal of Physiology 263, H1770-H1778.
 Mchedlishvili, G., Maeda, N., 2001. Blood flow structure related to red cell flow: a determination of blood fluidity in narrow microvessels. Japanese Journal of Physiology 51, 19-30.
 Botnar R, Rappitsch G, Scheidegger MB, Liepsch D, Perktold K, Boesiger P., 2000. Hemodynamics in the carotid artery bifurcation: a comparison between numerical simulations and in vitro measurements. J Biomech 33, 137-44.
 Hughes TH, Taylor C, Zarins C., 1998. Finite element modelling of blood flow in arteries. Comput Meth Appl Mech Eng 158, 155-96.
 Quarteroni A, Tuveri M, Veneziani A., 2000. Computational vascular fluid dynamics: problems, models and methods. Comput Visual Sci 2, 163-97.
 Sherwin SJ, Shah O, Doorly DJ, Peir_oJ, Papaharilaou Y, Watkins N, et al., 2000. The influence of out-of-plane geometry on the flow within a distal end-to-side anastomosis. ASME J Biomech 122, 1-10.