Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 32128
Quantitative Determination of Trace Elements in Some Oriental Herb Products

Authors: Nguyen Thi Kim Dzung, Pham Ngoc Khai, Rainer Ludwig


The quantitative determination of several trace elements (Cr, As, Se, Cd, Hg, Pb) existing as inorganic impurities in some oriental herb-products such as Lingzhi Mushroom capsules, Philamin powder, etc using ICP-MS has been studied. Various instrumental parameters such as power, gas flow rate, sample depth, as well as the concentration of nitric acid and thick background due to high concentration of possible interferences on the determination of these above-mentioned elements was investigated and the optimum working conditions of the sample measurement on ICP-MS (Agilent-7500a) were reported. Appropriate isotope internal standards were also used to improve the accuracy of mercury determination. Optimal parameters for sampling digestion were also investigated. The recovery of analytical procedure was examined by using a Certified Reference Material (IAEA-CRM 359). The recommended procedure was then applied for the quantitative determination of Cr, As, Se, Cd, Hg, Pb in Lingzhi Mushroom capsule, and Philamine powder samples. The reproducibility of sample measurement (average value between 94 and 102%) and the uncertainty of analytical data (less than 20%) are acceptable.

Keywords: Oriental herbal product, trace elements, ICP-MS, biochemistry, medical chemistry.

Digital Object Identifier (DOI):

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3548


[1] Garg A., Kumar A., Nair A., Reddy A., "Analysis of some Indian medicinal herbs by INAA" J. Radioanal. and Nucl. Chem.. Vol. 271, No 3, Mar. 2007, pp. 611-619 (9).
[2] U.Bober, D.Chen, "A powerful tool for analysis of heavy metals in traditional Chinese medicines", Agilent ePharmaceutical Analysis, Issue 15, 2005.
[3] Chu-Fang Wang, Ming-Jenq Duo, E.E.Chang and Jenq Yann Yang, "Essential and toxic trace elements in the Chinese medicine". J.Radioanal. and Nucl. Chem.. Vol. 211. No 2 Dec. 1996. pp. 333-347.
[4] S.Başgel and S.B. Erdemoğlu. "Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey". Sci. of the total Environt, Vol. 359, Issue 1-3, 15 Apr. 2006, pp 82-89.
[5] Han-wen Sun, Feng-xia Qiao, Ran Suo, Li-xin Li and Shu-xuan Liang, "Simultaneous determination of trace arsenic(III), antimony(III), total arsenic and antimony in Chinese medicinal herbs by hydride generation-double channel atomic fluorescence spectrometry", Analytica Chimica Acta, Vol. 505, Issue 2, 10 Mar. 2004, pp 255-261.
[6] Tianlong Deng, Mengxia Liao, Minru Jia, "Arsenic Speciation in Chinese Herb Ligusticum chuanxiong Hort by Hydride Generation Atomic Fluorescence Spectrometry", Spectroscopy Letters, Vol. 38, Issue 2 Mar. 2005, pp 109 - 119.
[7] N. Efe, H. Yilmaz, A. Zararsiz and P. Arikan "Application of calibration standardization method to the analysis of diuretic pharmaceutical herbs", J.Radioanal. and Nucl. Chem., Vol. 238, No 1-2 Dec. 1998, pp 97-99.
[8] Musa Ozcan, "Determination of Mineral Contents of Turkish Herbal Tea (Salvia aucheri var. canescens) at Different Infusion Periods", Journal of Medicinal Food, 2005, 8(1) pp 110-112.
[9] Silvia Arce, Soledad Cerutti, Roberto Olsina, María R. Gomez, Luis D. Martínez, "Determination of Metal Content in Valerian Root Phytopharmaceutical Derivatives by Atomic Spectrometry" Journal of AOAC international, January 2005, Vol. 88, Issue: 1, pp 221-225.
[10] Nazim Sekeroglu, Faruk Ozkutlu, S. Metin Kara, Mensure Ozguven, "Determination of cadmium and selected micronutrients in commonly used and traded medicinal plants in Turkey", Journal of the Science of Food and Agriculture (Research Article).
[11] I. Queralt , M. Ovejero, M.L. Carvalho, A.F. Marques, J.M.Llabrés, "Quantitative determination of essential and trace element content of medicinal plants and their infusions by XRF and ICP techniques", X-Ray Spectrometry, Vol. 34. Issue 3 . pp 213 - 217.
[12] Kalny P., Fijałek Z., Daszczuk A., Ostapczuk P.,"Determination of selected microelements in polish herbs and their infusions", Sci Total Environ, 2007, Aug 1;381(1-3):99-104. E-publication 2007 Apr. 30.
[13] U.Divrikli, N.Horzum, M.Soylak, L.Elci, "Trace heavy metal contents of some spices and herbal plants from western Anatolia. Turkey". Int. J.of Food Sci. & Technol., Vol. 41, Issue 6 pp. 712-716 (June 2006).
[14] Agilent "Determination of Heavy Metals in Whole Blood by ICP-MS Printed 3/2001 Publication number 5988-0533EN.
[15] Quality control methods for medicinal plant materials, World Health Organization, Geneva-1998.