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A Review on Application of Chitosan as a Natural Antimicrobial
Abstract:In recent years application of natural antimicrobials instead of conventional ones, due to their hazardous effects on health, has got serious attentions. On the basis of the results of different studies, chitosan, a natural bio-degradable and non-toxic biopolysaccharide derived from chitin, has potential to be used as a natural antimicrobial. Chitosan has exhibited high antimicrobial activity against a wide variety of pathogenic and spoilage microorganisms, including fungi, and Gram-positive and Gramnegative bacteria. The antimicrobial action is influenced by intrinsic factors such as the type of chitosan, the degree of chitosan polymerization and extrinsic factors such as the microbial organism, the environmental conditions and presence of the other components. The use of chitosan in food systems should be based on sufficient knowledge of the complex mechanisms of its antimicrobial mode of action. In this article we review a number of studies on the investigation of chitosan antimicrobial properties and application of them in culture and food mediums.
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 S. Arcidiacono, and D. L. Kaplan, "Molecular weight distribution of chitosan isolated from Mucor rouxii under different culture and processing conditions," Biotechnology and Bioengineering, vol. 39, pp. 281-286, 1992.
 S. Chatterjee, M. Adhya, A. K. Guha, and B. P. Chatterjee, "Chitosan from Mucor rouxii: production and physico-chemical characterization," Process Biochemistry, vol. 40, pp. 395-400, 2005.
 P. C. Srinivasa, and R. N. Tharanathan, "Chitin/Chitosan ÔÇö Safe, Ecofriendly Packaging Materials with Multiple Potential Uses," Food Reviews International, vol. 23, no. 1, pp. 53-72, 2007.
 M. N. V. Ravikumar, "A review of chitin and chitosan application. Reactive Functional Polymer, vol. 46, pp. 1-27, 2000.
 N. Liu, X. G. Chen, H. J. Park, C. G. Liu, C. S. Liu, X. H. Meng, and L. J. Yu, "Effect of MW and concentration of chitosan on antibacterial activity of Escherichia coli," Carbohydrate Polymers, vol. 64, pp. 60-65, 2006.
 H. K. No, N. Y. Park, S. H. Lee, H. J. Hwang, and S. P. Meyers, "Antibacterial activities of chitosans and chitosan oligomers with different molecular weights on spoilage bacteria isolated from tofu," Journal of Food Science, vol. 67, no. 4, pp.1511-1514, 2002.
 H. Sashiwa and S. Aiba, "Chemically modified chitin and chitosan as biomaterials," Progress in Polymer Science, vol. 29, pp. 887-908, 2004.
 C. Qin, H. Li, Q. Xiao, Y. Liu, J. Zhu and Y. Du, "Water-solubility of chitosan and its antimicrobial activity," Carbohydrate Polymers, vol. 63, no. 3, pp. 367-374, 2006.
 A. B. Mart├¡n-Diana, D. Rico, J. M. Barat, C. Barry-Ryan, "Orange juices enriched with chitosan: Optimisation for extending the shelf-life," Innovative Food Science and Emerging Technologies, vol. 10, pp. 590- 600, 2009.
 V. Coma, A. Deschamps, and A. Martial-Gros, "Bioactive packaging materials from edible chitosan polymerÔÇöAntimicrobial activity assessment on dairy-related contaminants, Journal of Food Science, vol. 68, no. 9, pp. 2788-2792, 2003.
 F. Devlieghere, A. Vermeulen, and J. Debevere, "Chitosan: antimicrobial activity, interactions with food components and applicability as a coating on fruit and vegetables," Food Microbiology, vol. 21, pp. 703-714, 2004.
 Y. C. Chung, Y. P. Su, C. C. Chen, G. Jia, H. L. Wang, J. C. G. Wu, and J. G. Lin, "Relationship between antibacterial activity of chitosan and surface characteristics of cell wall," Acta Pharmacologica Sinica, vol. 25, no. 7, pp. 932-936, July 2004.
 D. Raafat, K. Bargen, A. Haas, and H. G. Sahl, "Insights into the mode of action of chitosan as an antibacterial compound," Appied and Environmental Microbiology, vol. 74, no. 12. pp. 3764-3773, June 2008.
 Y. J. Jeon, and S. K. Kim, "Production of chitooligosaccharides using an ultrafiltration membrane reactor and their antibacterial activity," Carbohydrate Polymers, vol. 41, pp. 133-144, 2000.
 Y.Omura, M. Shigemoto, T. Akiyama, H. Saimoto, Y. Shigemasa, I. Nakamura, T. Tsuchido, "Reexamination of antimicrobial activity of chitosan having different degrees of acetylation and molecular weights," Advances in Chitin Science, vol. 6, pp. 273-274, 2002.
 L. Y. Zheng,. and J. F. Zhu, "Study on antimicrobial activity of chitosan with different molecular weights," Carbohydrate Polymers, vol. 54, pp. 527-530, 2003.
 D. Raafat and H. G. Sahl, "Chitosan and its antimicrobial potential - a critical literature survey," Microbial Biotechnology, vol. 2, no. 2, pp. 186-201, 2009.
 R. C. Goy, D. Britto, O. B. G. Assis, "A review of the antimicrobial activity of chitosan.," Pol├¡meros: Ci├¬ncia e Tecnologia, vol. 19, no 3, pp. 241-247, 2009.
 T. C.Yang, C. C. Chou, and C. F. Li, "Preparation, water solubility and rheological property of the N-alkylated mono or disaccharide chitosan derivatives," Food Research International, vol. 35, pp. 707- 713, 2002.
 T. C. Yang, C. C. Chou, and C. F. Li, "Antibacterial activity of Nalkylated disaccharide chitosan derivatives," International Journal of Food Microbiology, vol. 97, pp. 237- 245, 2005.
 X. Li, X. Shi, M. Wang, and Y. Du, "Xylan chitosan conjugate - a potential food preservative," Food Chemistry, vol. 126. no. 2, pp. 520- 525, May 2011.
 ├û. V. R├║narsson, J. Holappa, T. Nevalainen, M. Hj├ílmarsd├│ttir, T. J├ñrvinen, T. Loftsson, J. M. Einarsson, S. J├│nsd├│ttir, M. Valdimarsd├│ttir, M. M├ísson, "Antibacterial activity of methylated chitosan and chitooligomer derivatives: Synthesis and structure activity relationships," European Polymer Journal, vol. 43, no. 6, pp. 2660-2671, 2007.
 N. Vallapa, O. Wiarachai, N. Thongchul, J. Pan, V. Tangpasuthadol, S. Kiatkamjornwong and V. P. Hoven, "Enhancing antibacterial activity of chitosan surface by heterogeneous quaternization," Carbohydrate Polymers, vol. 83, no. 2, pp. 868-875, 2011.
 X. F. Liu, Y. L. Guan, D. Z. Yang, Z. Li, and K. D. Yao, "Antibacterial action of chitosan and carboxymethylated chitosan," Journal of Applied Polymer Science, vol. 79, no. 7, pp. 1324-1335, 2000.
 G. He, X. Chen, Y. Yin, H. Zheng, X. Xiong and Y. Du, "Synthesis, characterization and antibacterial activity of salicyloyl chitosan," Carbohydrate Polymers, vol. 83, no. 3, pp. 1274-1278, Jan 2011.
 Y. Feng, and W. Xia, "Preparation, characterization and antibacterial activity of water-soluble O-fumaryl-chitosan," Carbohydrate Polymers, vol. 83, no. 3, pp. 1169-1173, Jan 2011.
 H. Tang, P. Zhang, T. L. Kieft, S. J. Ryan, S. M. Baker, W. P. Wiesmann, and S. Rogelj, "Antibacterial action of a novel functionalized chitosan-arginine against Gram-negative bacteria," Acta Biomaterialia, vol. 6, no. 7, pp. 2562-2571, 2010.
 Y. Hu, Y. Du, J. Yang, J. F. Kennedy, X. Wang and L. Wang, "Synthesis, characterization and antibacterial activity of guanidinylated chitosan," Carbohydrate Polymers, vol. 67, no. 1, pp. 66-72, 2007.
 R. L. Beverlya, M. E. Janesa, W. Prinyawiwatkula, H. K. No, "Edible chitosan films on ready-to-eat roast beef for the control of Listeria monocytogenes," Food Microbiology, vol. 25, pp. 534-537, 2008.
 R. Cao, C. H. Xue, and Q. Liu, "Changes in microbial flora of Pacific oysters (Crassostrea gigas) during refrigerated storage and its shelf-life extension by chitosan" International Journal of Food Microbiology, vol. 131, pp. 272-276, 2009.
 K. W. Kim, B. J. Min, Y. T. Kim, R. M. Kimmel, K. Cooksey, and S. I. Park, "Antimicrobial activity against foodborne pathogens of chitosan biopolymer films of different molecular weights" LWT - Food Science and Technology, vol. 44, pp. 565-569, 2011.
 P. Chhabra, Y. W. Huang, J. F. Frank, R. Chmielewski, and K. Gates, "Fate of staphylococcus aureus, salmonella enterica serovar typhimurium, and vibiro vulnificus in raw oysters treated with chitosan," Journal of Food Protection, vol. 69, pp. 952-959, 2006.
 S. Chaiyakosa, W. Charernjiratragul, K. Umsakul and V. Vuddhakul, "Comparing the efficiency of chitosan with chlorine for reducing Vibrio parahaemolyticus in shrimp," Food Control, vol. 18, no. 9, pp.1031- 1035, 2007.
 S. M. A. Taha, and H. M. H. Swailam, "Antibacterial activity of chitosan against Aeromonas hydrophila," Food / Nahrung, vol. 76, no. 5, pp. 337- 340, 2002.
 G. J. Tsai, M. T. Tsai, J. M. Lee, and M. Z. Zhong, "Effects of chitosan and a low-molecular-weight chitosan an Bacillus cereus and application in the preservation of cooked rice," Journal of Food Protection, vol. 69, no. 9, pp. 2168-2175, 2006.
 P. Fernandez-Saiz, C. Soler, J. M. Lagaron and M. J.Ocio, "Effects of chitosan films on the growth of Listeria monocytogenes, Staphylococcus aureus and Salmonella spp. in laboratory media and in fish soup," International Journal of Food Microbiology, vol. 137, no. 2, pp. 287- 294, 2010.
 M. Ye, H. Neetoo, H. Chen, "Control of Listeria monocytogenes on ham steaks by antimicrobials incorporated into chitosan-coated plastic films," Food Microbiology, vol. 25, no. 2, p. 260-268, 2008.
 S. Roller, and N. Covill, "The antifungal properties of chitosan in laboratory media and apple juice," International Journal of Food Microbiology, vol. 47, pp. 67-77, Mar 1999.
 M. S. Rodr├¡guez, V. Ramos, and E. Agull├│, "Antimicrobial action of chitosan against spoilage organisms in precooked pizza," Journal of Food Science, vol. 68, no. 1, pp. 271-274, 2006.
 S. I. Park, K. S. Marsh, and P. Dawson, "Application of chitosanincorporated LDPE film to sliced fresh red meats for shelf life extension," Meat Science, vol. 85, pp. 493-499, 2010.
 R. D. Joerger, S. Sabesan, D. Visioli, D. Urian, and M. C. Joerger, "Antimicrobial activity of chitosan attached to ethylene copolymer films," Packaging Technology and Science, vol. 22, no. 3, pp. 125-138, 2008.
 P. Fernandez-Saiz, M. J. Ocio, and J. M. Lagaron, "Antibacterial chitosan-based blends with ethylene-vinyl alcohol copolymer," Carbohydrate Polymers, vol. 80, no. 3, pp. 874-884, 2010.
 S. Tripathi, G. K. Mehrotra and P. K. Dutta, "Physicochemical and bioactivity of cross-linked chitosan-PVA film for food packaging applications," International Journal of Biological Macromolecules, vol. 45, no. 4, pp. 372-376, 2009.
 F. Sebastien, G. Stephane, A. Copinet, and V. Coma, "Novel biodegradable films made from chitosan and poly(lactic acid) with antifungal properties against mycotoxinogen strains," Carbohydrate Polymers, vol. 65, pp.185-193, 2006.
 F. Liu, B. Qin, L. He, and R. Song, "Novel starch/chitosan blending membrane: Antibacterial, permeable and mechanical properties," Carbohydrate Polymers. vol. 78, no. 1, pp. 146-150, 2009.
 C. M. Shih, Y. T. Shieh and Y. K. Twu, "Preparation and characterization of cellulose/chitosan blend films," Carbohydrate Polymers, vol. 78, no. 1, pp. 169-174, 2009.
 M. E. Lopez-Caballero, M. C. Gomez-Guillen, M. Perez-Mateos and P. Montero, "A chitosan-gelatin blend as a coating for fish patties," Food Hydrocolloids, vol. 19, pp. 303-311, 2005.
L. Y. Sang, X. H. Zhou, F. Yun, and G. L. Zhang, "Enzymatic synthesis of chitosan-gelatin antimicrobial copolymer and its characterization," Journal of the Science of Food and Agriculture, vol. 90, pp. 58-64, 2010.