Subcritical Water Extraction of Mannitol from Olive Leaves

Authors: S. M. Ghoreishi, R. Gholami Shahrestani, S. H. Ghaziaskar

Abstract:

Subcritical water extraction was investigated as a novel and alternative technology in the food and pharmaceutical industry for the separation of Mannitol from olive leaves and its results was compared with those of Soxhlet extraction. The effects of temperature, pressure, and flow rate of water and also momentum and mass transfer dimensionless variables such as Reynolds and Peclet Numbers on extraction yield and equilibrium partition coefficient were investigated. The 30-110 bars, 60-150°C, and flow rates of 0.2-2 mL/min were the water operating conditions. The results revealed that the highest Mannitol yield was obtained at 100°C and 50 bars. However, extraction of Mannitol was not influenced by the variations of flow rate. The mathematical modeling of experimental measurements was also investigated and the model is capable of predicting the experimental measurements very well. In addition, the results indicated higher extraction yield for the subcritical water extraction in contrast to Soxhlet method.

Keywords: Extraction, Mannitol, Modeling, Olive leaves, Soxhlet extraction, Subcritical water.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1062566

References:

[1] F. Niklas, W. V. Weymarn, K. J. Kiviharju, S. T. Jala1skela1inen, M. S. A. Leisola, "Scale-up of a new bacterial Mannitol production process," Biotechnol. Prog., vol. 19, pp. 815-821, 2003.
[2] W. Soetaert, P. T. Vanhooren, E. J. Vandamme, "Production of Mannitol by fermentation," Method Biotechnol., vol 10, pp. 261-275, 1999.
[3] H. Kirk, D. Othmer, Encyclopedia of Chemical Technology. New York: Wiley, 1978.
[4] E. Oddo, F. Saiano, G. Alonzo, E. Bellini, "An investigation of the seasonal pattern of Mannitol content in deciduous and evergreen species of the Oleaceae growing in Northern Sicily," Ann. Bot., vol. 90, pp. 239- 243, 2002.
[5] R. Gholami Shahrestani, "Experimental extraction of Mannitol from olive tree leaf by using supercritical carbon dioxide and subcritical water," Dissertation, Dept. Chem. Eng., Isfahan Univ. Technol., 2007.
[6] F. M. Racine, B. C. Saha, "Production of Mannitol by Lactobacillus Intermedius NRRL B3693 in Fed-batch and Continuous Cell-recycle Fermentations," Process Biochem., vol. 42 (12), pp. 1609-1613, 2007.
[7] C. Baumchen, A. H. F. J. Roth, R. Biedendieck, M. Malten, M. Follmann, H. Sahm, S. Bringer-Meyer, D. Jahn, "D-Mannitol Production by Resting State Whole Cell Biotransformation of D-Fructose by Heterologous Mannitol and Formate Dehydrogenase Gene Expression in Bacillus Megaterium," Biotechnol. J., vol. 2, pp. 1408-1416, 2007.
[8] H. W. Wisselink, R. A. Weusthuis, G. Eggink, J. Hugenholtz, G. J. Grobben, "Mannitol Production by Lactic Acid Bacteria: a Review," Int. Dairy J., vol. 12, pp. 151-161, 2002.
[9] B. Elvers, S. Hawkins, W. Russey, Ullman-s Encyclopedia of Industrial Chemistry. Weinheim: VCH, 1994.
[10] S. M. Ghoreishi, S. Sharifi, "Modeling of supercritical extraction of Mannitol from plane tree leaf," J. Pharmaceut. Biomed. Anal., vol. 24, pp. 1073-1048, 2001.
[11] R. M. Smith, "Superheated water: The ultimate green solvent for separation science," Anal. Bioanal. Chem., vol. 385(3), pp. 419-421, 2006.
[12] D. J. Miller, S. B. Hawthorne, "Solubility of liquid organics of environmental interest in subcritical (hot/liquid) water from 298 K to 473 K," J. Chem. Eng. Data, vol. 45, pp. 78-81, 2000.
[13] M. Herrero, A. Cifuentes, E. Ibanez, "Sub- and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by-products, algae and microalgae: A review," Food Chem., vol. 98, pp. 136-148, 2006.
[14] M. M. Jimenez-Carmona, J. L. Ubera, M. D. Luque de Castro, "Comparison of continuous subcritical water extraction and hydrodistillation of marjoram essential oil," J. of Chromatogr. A, vol. 855, pp. 625-632, 1999.
[15] E. S. Ong, S. M. Len, "Evaluation of pressurized liquid extraction and pressurized hot water extraction for tanshinone I and IIA in Salvia miltiorrhiza using LC and LC-ESI-MS," J. Chromatogr. Sci., vol. 42, pp. 212-216, 2004.
[16] M. H. Eikani, F. Golmohammad, S. Rowshanzamir, "Subcritical water extraction of essential oils from coriander seeds (Coriandrum sativum L.)," J. Food Eng., vol. 80, pp. 735-740, 2007.
[17] Y. Xia, M. E. Rivero-Huguet, B. H. Hughes, W. D. Marshall, "Isolation of the sweet components from Siraitia grosvenorii," Food Chem., vol. 107, pp. 1022-1028, 2008.
[18] A. Kubatova, D. J. Miller, S. B. Hawthorne, "Comparison of subcritical water and organic solvents for extracting kava lactones from kava root," J. Chromatogr. A, vol. 923, pp. 187-194, 2001.
[19] Q. Lang, C. M. Wai, "Pressurized water extraction (PWE) of terpene trilactones from Ginkgo biloba leaves," Green Chem., vol. 5, pp. 415- 420, 2003.
[20] R. Jap'on-Luj'an, M.D. Luque de Castro, "Superheated liquid extraction of oleuropein and related biophenols from olive leaves," J. Chromatogr. A, vol. 1136, pp. 185-191, 2006.
[21] Dionxin. Research Group, www.dionex.com, Application Note 312-335.
[22] P. Gaspar, A. Rute Neves, A. Ramos, M. J. Gasson, C. A. Shearman, H. Santos, "Engineering Lactococcus lactis for Production of Mannitol: High Yields from Food-Grade Strains Deficient in Lactate Dehydrogenase and the Mannitol Transport System," App. Environ. Microb., vol. 70, pp. 1466-1474, 2004.
[23] D. Mongkholkhajornsilp, S. Douglas, P. L. Douglas, A. Elkamel, W. Teppaitoon, S. Pongamphai, "Supercritical CO2 extraction of nimbin from neem seeds--a modeling study," J. Food Eng., vol. 71, pp. 331- 340, 2005.
[24] R. J. Redgwell, "Fractionation of plant extracts using ion-exchange Sephadex," Anal. Biochem., vol. 107, pp. 44-50, 1980.
[25] W. H. Loescher, G. C. Marlow, R. A. Kennedy, "Sorbitol metabolism and sink-source interconversions in developing apple leaves," Plant Physiol., vol. 70, pp. 335-339, 1982.
[26] C. T. Erkey, Y. Guo, C. Erkey, A. Akgernam, "Mathematical modeling of adsorption and desorption of volatile contaminants from soil: influence of isotherm shape on adsorption and desorption profiles," Environ. Sci. Technol., vol. 30, pp. 2127-2134, 1996.
[27] L. Barna, R. Bayard, J. M. Blanchard, R. Gourdon, "Modelling and simulation of hydrocarbon mobility in soil-water and soil-supercritical carbon dioxide systems," Chem. Eng. Sci., vol. 53, pp. 639-649, 1998.
[28] N. Wakao, S. Kaguei, Heat and Mass Transfer in Packed Beds. New York: Gordan and Breach, 1982.
[29] G. Brunner, "Mass transfer in gas extraction," in Supercritical Fluid Technology, J. M. L. Penniger, M. Radosz, M. A. McHugh, V. J. Krukonis, Ed. Amsterdam: Elsevier, 1985, pp. 245-250.
[30] J. M. Smith, Chemical Engineering Kinetics. New York: McGraw-Hill, 1981.
[31] R. V. Rohr, A. Baiker, J. W. Tester, "Transpiring Wall Reactor for Supercritical Water Oxidation," Ph.D. dissertation, Swiss Fed. Ins. of Technol. Zurich, Zurich, 2003.
[32] J. Bear, Dynamics of Fluid in Porous Media. New York: America Elsevier Pub. Co., 1972.
[33] S. M. Ghoreishi, A. Akgerman, "Dispersion coefficients of supercritical fluid in fixed beds," Sep. Purif. Technol., vol. 39, pp. 39-50, 2004.
[34] B. Nauman, Chemical reactor design, optimization, and scaled up. McGraw-Hill, 2002.
[35] N. V. Weymarn, "Process of Development for Mannitol Production by Lactic Acid Bacteria," PhD dissertation, Dept. Chem. Technol., Helsinki Univ. Technol., 2002.
[36] R. H. Perry, D. W. Green, J. O. Maloney, Perry-s Chemical Engineers- Handbook. 7th ed., New York: McGraw-Hill, 1997, pp. 2-40.
[37] M. D. David, S. Campbell, Q. W. Li, "Pressurized fluid extraction of nonpolar pesticides and polar herbicides using in situ derivatization," Anal. Chem., vol. 72, pp. 3665-3670, 2000.