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Biomimetic Preparation of Nano Hydroxyapatite in Gelatin-Starch Matrix

Authors: M.Meskinfam, M. S. Sadjadi, H.Jazdarreh


In this study, we report the synthesis and characterization of nanohydroxyapatite (nHAp) in gelatin-starch matrix via biomimetic method. Characterization of the samples was performed using X-ray diffraction (XRD) and Fourier Transform infrared spectroscopy (FT-IR). The Size and morphology of the nHAp samples were determined using scanning and transmission electron microscopy (SEM and TEM). The results reveal that the shape and morphology of nHAp is influenced by presence of biopolymers as template. Carbonyl and amino groups from gelatin and hydroxyl from starch play crucial roles in HAp formation on the surface of gelatin-starch.

Keywords: Biomimetic, biocomposite, template, Nano Hydroxyapatite

Digital Object Identifier (DOI):

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[1] J. Sundaram, T.D. Durance, R. Wang, , "Porous scaffold of gelatin- starch with nanohydroxyapatite composite processed via novel microwave vacuum drying", Acta Biomaterialia , vol.4, 2008, pp. 932- 942.
[2] Sh. Teng, L. Chen, Y. Guo, J. Shi, , "Formation of nano-hydroxyapatite in gelatin droplets and the resulting porous composite micro spheres" , Journal of Inorganic Biochemistry, vol. 101, 2007, pp. 686-691.
[3] J. Pe˜na, I. Izquierdo-Barba, M.A. Garc'Ûa, M. Vallet-Reg, "Room temperature synthesis of chitosan/apatite powders and coatings", Journal of the European Ceramic Society, vol. 26, 2006, pp. 3631-3638.
[4] H. W. Kim, H. E. Kim, V. Salih , "Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds", Biomaterials, vol. 26, 2005, pp. 5221-5230.
[5] H.-W. Kim, J.C. Knowles, H.-E. Kim, "Gelatin/hydroxyapatite nanocomposite scaffolds for bone repair", J. Biomed. Mater. Res. Vol. 72A, 2005, pp. 136-145.
[6] H. Ishikawa, T. Koshino, R. Takeuchi, T. Saito, "Hydroxyapatite and gelatin composite foams processed via novel freeze-drying and crosslinking for use as temporary hard tissue scaffolds", Biomaterials , vol. 22, 2001, pp. 1689-1694.
[7] J. F.Mano, Rui A.Sousa, Luciano F.Boesel, Nuno M.Neves, Rui L.Reis, "Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: state of the art and recent developments", Composites Science and Technology, vol. 64, 2004 , pp. 789-817.
[8] D.C. Dragunski, A. Pawlicka," Preparation and Characterization of Starch Grafted with Toluene Poly(propylene oxide) Diisocyanate", Materials Research, vol.4, 2001, pp. 77-81
[9] R. Shi, T. Ding, Q. Liu, Y. Han, L. Zhang, , D. Chen, , W. Tian , "In vitro degradation and swelling behavior of rubbery thermoplastic starch in simulated body and simulated saliva fluid and effects of the degradation products on cells", Polymer Degradation and Stability, vol. 91, 2006, pp. 3289-3300.
[10] Kunal Pal, Ajit K. Banthia, Dipak K. Majumdar, "Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications", AAPS Pharm.Sci.Tech. vol. 8, 2007 pp. 142- 146.
[11] Y. W, JingDi Chen., K.Wei, S.Hua Zhang, X. Wang, "Surfactantassisted synthesis of hydroxyapatite particles", Materials Letters, vol. 60 , 2006, pp. 3227-3231.
[12] A. Sinha and A. Guha , "Biomimetic patterning of polymer hydrogels with hydroxyapatite nanoparticles", Materials Science & Engineering C, vol. 29, 2008, pp. 1330 - 1333.
[13] Li Wang, Chunzhong Li, "Preparation and physicochemical properties of a novel hydroxyapatite/chitosan-silk fibroin composite", Carbohydrate Polymers, vol. 68, 2007, pp. 740-745.