Commenced in January 2007
Paper Count: 30309
Dextran Modified Silicon Photonic Microring Resonator Sensors
Abstract:We present a dextran modified silicon microring resonator sensor for high density antibody immobilization. An array of sensors consisting of three sensor rings and a reference ring was fabricated and its surface sensitivity and the limit of detection were obtained using polyelectrolyte multilayers. The mass sensitivity and the limit of detection of the fabricated sensor ring are 0.35 nm/ng mm-2 and 42.8 pg/mm2 in air, respectively. Dextran modified sensor surface was successfully prepared by covalent grafting of oxidized dextran on 3-aminopropyltriethoxysilane (APTES) modified silicon sensor surface. The antibody immobilization on hydrogel dextran matrix improves 40% compared to traditional antibody immobilization method via APTES and glutaraldehyde linkage.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1060553Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1801
 A. L. Washburn, R. C. Bailey, "Photonics-on-a-chip: recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications," Analyst, vol. 126, pp. 227-236, 2010.
 K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, R. Baets. "Siliconon- Insulator microring resonator for sensitive and Label-free Biosensing, " Optical Express, v.15, pp. 7610-7615, June 2007.
 C. F. Carlborg, K. B. Gylfason, A. Kazmierczak, F. Dortu, M. J. Ba~nuls Polo, A. Maquieira Catala, et al. "A packaged optical slotwaveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips," Lap on a Chip, vol. 10, pp. 281-290, 2010.
 A. Densmore, M. Vachon, D.-X. Xu, S. Janz, R. Ma, Y.-H. Li, et al. "Silicon photonic wire biosensor array for multiplexed real-time and label-free molecular detection," Optics Letters, vol. 34, pp.3598-3600, December 2009.
 S. Mandal and D. Erickson, "Nanoscale optofluidic sensor arrays," Opt. Express, vol. 16, pp. 1623-1631, Fabruary 2010.
 M. Iqbal, M. A. Gleeson, B. Spaugh, F.Tybor, W. G. Gunn, M. Hochberg, et al. "Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation," IEEE J. Sel. Top. Quantum Electronics, vol.16, pp. 654-661, May/June 2010.
 A. L. Washburn, M. S. Luchansky, A. L. Bowman, R. C. Bailey, "Quantitative, Label-Free Detection of Five Protein Biomarkers Using Multiplexed Arrays of Silicon Photonic Microring Resonators," Anal. Chem., vol. 82, pp. 69-72, 2010.
 A. J. Qavi, J. T. Kindt, M. A. Gleeson, R. C. Bailey, "Anti-DNA:RNA Antibodies and Silicon Photonic Microring Resonators: Increased Sensitivity for Multiplexed microRNA Detection," Anal. Chem., vol. 83, pp. 5949-5956, 2011.
 J.-O Lee, H.-M. So, E.-K. Jeon, H. Chang, K. Won, Y. H. Kim, "Aptamers as molecular recognition elements for electrical nanobiosensors," Anal. Bioanal. Chem. Vo. 390, pp. 1023-1032, 2008.
 Z. Feldötö, I. Varga, E. Blomberg, "Influence of salt and rinsing protocol on the structure of PAH/PSS polyelectrolyte multilayers," Langmuir,vo.l 26, pp. 17048-17057, 2010.
 F. Caruso, K. Niikura, D.N. Furlong, Y. Okahata, 1. Ultrathin multilayer polyelectrolyte films on gold: construction and thickness determination, Langmuir, 13 (1997) 3422-3426.